10 Best Cat Sedatives For Travel 2025 in the United States

The FELIWAY Classic Cat Calming Pheromone Travel Spray is a drug-free, non-sedating solution designed to help reduce stress in cats, particularly during travel. It uses synthetic pheromones that mimic natural feline facial pheromones, which can aid in calming cats and reducing behaviors like scratching, urine spraying, and hiding. This makes it particularly useful for car rides, vet visits, and adjusting to new environments.

Simply spray it on your cat's carrier or a blanket 15 minutes before use, but do not spray it directly on your cat. The 20 mL bottle provides approximately 125 uses, making it quite economical. A major strength is its ease of use and the fact that it is suitable for cats of all breeds and life stages. It is also supported by 25 years of feline stress expertise.

It’s important to note that the product is not a sedative and may not be as effective for cats with severe anxiety. While the majority of cats show improvement, it may not work for all. Being drug-free means it has no major side effects, making it a safer option compared to prescription sedatives. This product is ideal for cat owners looking for a gentle, non-prescriptive way to calm their pets during travel or environmental changes.

Sentry Calming Chews for Cats are designed to help manage stress and anxiety in cats through a scientifically proven formula. These chews contain pheromones that can help curb destructive behavior and separation anxiety, making them suitable for use during travel or other stressful situations.

The chews have a crunchy exterior and a creamy interior, which many cats find appealing. These chews are natural supplements rather than prescription medication, adding to their safety profile. Each chew is dosed per the cat's weight, with a clear guideline of 1 chew per 1 lb of weight daily, ensuring easy administration and proper dosage control. Users should be mindful not to exceed the recommended daily amount.

The product is manufactured in the USA and comes in a 4-ounce package. Sentry Calming Chews are particularly beneficial for cat owners who prefer a natural, non-prescription option to manage their pet's anxiety.

The Bach RESCUE Remedy PET Dropper is a natural, homeopathic solution aimed at easing stress and anxiety in pets, including cats, during travel and other stressful situations. It’s made from a blend of five natural flower essences and is sedative-free, making it a suitable option for pet owners who prefer a more holistic approach to calming their pets.

One of its strengths is that it's versatile and can be used on various pets such as dogs, cats, horses, rabbits, birds, and lizards. Additionally, it is free from artificial flavors, colors, sugar, gluten, and major allergens. The product is also non-alcoholic and non-habit forming, which is a significant advantage over some prescription alternatives. The liquid form makes it relatively easy to administer either directly into the mouth or mixed with food or water.

However, there are a few drawbacks to consider. The effectiveness of homeopathic remedies can vary significantly from one pet to another, and some may not experience the desired calming effect. Moreover, since it is sedative-free, it may not be as effective in highly stressful situations compared to stronger, prescription sedatives. The lack of specific information on the duration of effect can also be a downside for users seeking a long-lasting solution. It is a good option for those looking for a gentle, natural remedy for mild to moderate stress in pets during travel.