10 Best Cat Urine Cleaners With Enzymes 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a strong contender in the cat urine cleaner category, especially beneficial for pet owners dealing with tough stains and odors. One of its standout features is the enzyme-based formula, which effectively breaks down organic matter and ammonia crystals, targeting odor at its source. Users appreciate its ability to tackle a wide range of stains, from cat urine to vomit, making it versatile for various surfaces like carpets, floors, furniture, and even clothing.

Safety is a major plus; the product is chlorine-free and color-safe, certified as safe for carpets, pets, and children. This makes it an excellent choice for households with multiple pets or young kids, giving peace of mind during use. The application method is straightforward—simply spray and let the enzymes do their work, although drying time may vary depending on the surface.

There are a few considerations to keep in mind. While many customers report high satisfaction, some might find that it requires a bit more time or product to fully eliminate persistent odors, especially in older stains. Additionally, the original scent may not be to everyone's liking, so if you prefer a strong fragrance, this might not meet your expectations. Also, the product is available in a 32 oz size, and while this is adequate for many users, those with multiple pets or larger areas to clean might find it runs out quickly.

Rocco & Roxie’s cleaner is a reliable option for anyone dealing with pet-related messes, especially if you're looking for a safe, enzyme-based solution. Just be prepared to apply it generously in cases of heavy soiling, and consider your surface compatibility to make the most of its benefits.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is designed as a professional-strength solution that uses probiotics, which act similarly to enzymes, to break down odors and stains. It is a versatile cleaner suitable for floors, bathrooms, drains, and trash cans, making it especially useful for pet owners dealing with cat urine and other organic messes. The lemon scent provides a fresh, clean smell that helps mask unpleasant odors without being overpowering. It comes in a 1-gallon liquid form, making it efficient for larger cleaning tasks.

While the product lists floors as a specific use, its broad description suggests it should be safe on various surfaces, though testing in a small area first is recommended. The packaging size and weight indicate that it’s a concentrated product likely requiring dilution. Being biobased and made in the USA, it offers a potentially safer and more environmentally friendly option compared to harsh chemical cleaners.

This cleaner is well-suited for pet owners seeking a multi-surface enzyme-based product with a pleasant scent and eco-conscious formulation. Users are encouraged to test its compatibility and application methods to meet their specific cleaning needs.

Nature's Miracle Urine Destroyer Plus for Cats is designed specifically to tackle severe cat urine stains using a strong enzymatic formula. This formula starts breaking down stains immediately and keeps working as long as any mess remains, which helps remove both stain and odor effectively. The product comes in a large, 1-gallon bottle that’s easy to pour, making it practical for refilling smaller spray containers.

It is safe to use around pets and in homes when instructions are followed, which is important for households with multiple animals or children. The scent is labeled as an odor remover, so it aims to neutralize smells rather than mask them with heavy fragrances, which many pet owners will appreciate.

The bottle size and weight might be a bit bulky for some users, and it doesn’t include a spray nozzle, so you’ll need a separate spray bottle for easy application. This cleaner is a solid choice for cat owners dealing with tough urine stains who want a trusted enzymatic solution that’s safe and effective without overpowering scents.