10 Best Cat Urine Enzymatic Cleaners 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator stands out as a solid option in the enzymatic cleaner category, especially for cat urine and other pet-related messes. Its enzyme-based formula is effective at breaking down stains and odors at a deep level, targeting ammonia crystals and organic matter, which is crucial for tackling the tough spots left by pets. The product is versatile and can be safely used on a variety of surfaces, including carpets, furniture, and even clothing, making it a convenient choice for pet owners who have multiple areas to clean.

One of its key strengths is that it's certified safe for use around pets and children, being free from harmful chemicals like chlorine, which adds peace of mind for households with little ones. Additionally, it has a generous 32 oz size, offering ample product for multiple cleanings.

While the product is effective on many surfaces, it's important for users to test it on a small area first to avoid any potential discoloration, especially on delicate fabrics. The drying time is not specifically mentioned, which could be a factor for those wanting a quick solution after cleaning. Moreover, the satisfaction guarantee is reassuring, but it only applies to purchases from authorized sellers, which limits options for some customers.

The ANGRY ORANGE Pet Odor Eliminator is a powerful solution designed to tackle strong and persistent cat urine smells, thanks to its robust enzyme formula. This multipurpose cleaner is versatile and can be used on various surfaces like carpets, tile, couch upholstery, garbage cans, and even car interiors. Users will appreciate the fresh linen scent it leaves behind, which helps to neutralize unpleasant odors effectively.

The product comes in a convenient spray form, making it easy to apply. Just remove any excess mess, shake the bottle, spray the affected area, and let it dry completely for the best results. The manufacturer also offers responsive customer service, which is a plus if you encounter any issues. However, it's important to note that the drying time might vary depending on the surface and amount used, which could be a drawback for those needing a quick fix.

Additionally, always ensure pets are removed from the area during application for safety. This product acts manually, so it requires some physical effort to use. Despite a few minor inconveniences, the ANGRY ORANGE Pet Odor Eliminator stands out for its strong odor-fighting capabilities and pleasant scent, making it a solid choice for pet owners dealing with stubborn cat urine odors.

Urine B-Gone by Kinzua Environmental is a professional enzyme cleaner designed to tackle pet urine and stains effectively. With a potent formula containing 200 billion microbe colonies per gallon, it promises to eliminate odors and stains deeply and thoroughly. The enzyme formula is designed to break down urine and poop, making it a robust solution for keeping your home fresh. Additionally, it leaves a pleasant citrus scent, which can be a refreshing change from the typical chemical smells of cleaners.

This product is versatile, suitable for carpets, upholstery, laundry, drains, and even toilets, which adds to its utility. The formula also penetrates deep into surfaces, ensuring that even underlying padding and flooring remain odor-free. It is safe to use around pets and children when used as directed, providing peace of mind for households with little ones and fur babies.

The liquid form might make it a bit tricky to apply evenly, and some users might prefer a spray application method for ease. While the citrus scent is generally pleasant, scent preferences are subjective, and not everyone may enjoy it. The drying time isn't explicitly mentioned, but as with most enzymatic cleaners, allowing sufficient time for the product to work is crucial for optimal results. If you’re looking for a powerful and versatile enzymatic cleaner that’s safe for homes with pets and children, Urine B-Gone is a solid choice.