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10 Best Enzymatic Cleaners For Cat Urine 2025 in the United States

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Our Top Picks

#1

Winner

ANGRY ORANGE Pet Odor Eliminator for Cat Urine, Carpet Stains, and Strong Smells – Fresh Scent Odor Remover- 24 oz

Rating
10.0
Chosen by1,349
Application Method
Odor Control

Most important from
127050 reviews

Application Method
A little goes a long way; you don't need to soak the area, just spray and pat.
Odor Control
This product is incredibly effective at eliminating cat urine odor completely, with the smell not returning even after a long time.

The ANGRY ORANGE Pet Odor Eliminator is a spray designed to tackle cat urine odors with a fresh scent. It’s manually operated, which means you simply spray it where needed without any complicated setup. The product comes in a 24 oz bottle which is reasonably sized for frequent use. The fresh scent can effectively mask unpleasant smells, making your home more pleasant.

The spray form makes application easy and convenient, allowing you to target specific areas directly. It’s also important to note the surface compatibility; it’s typically safe for multiple surfaces, including carpets and upholstery, but it's always a good idea to test a small area first. In terms of drying time, you may need to check how long it takes to dry on different surfaces in your home.

If you’re unsatisfied, the company offers responsive customer service, which is a plus for addressing any potential issues. This cleaner seems effective for odor control and is easy to use, but you might need to explore further to ensure it meets all your specific requirements.

Rating
10.0
Chosen by1,349
Application Method
Odor Control

Most important from
127050 reviews

Application Method
A little goes a long way; you don't need to soak the area, just spray and pat.
Odor Control
This product is incredibly effective at eliminating cat urine odor completely, with the smell not returning even after a long time.
#2

Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
4626 reviews

Enzyme Type
The enzymatic formula starts working on contact and continues breaking down urine residues, ensuring deep, lasting cleaning.
Application Method
Safe and straightforward to use around pets and children, offering peace of mind in multi-animal households.
Surface Compatibility
Effectively removes tough cat urine stains and completely eliminates odors, even on challenging surfaces like mattresses.
Odor Control
Effectively removes tough cat urine stains and completely eliminates odors, even on challenging surfaces like mattresses.
Drying Time
Requires a 10-15 minute dwell time to fully neutralize odors; rushing this step can leave lingering smells.
Eco-Friendliness
Safe and straightforward to use around pets and children, offering peace of mind in multi-animal households.

Nature’s Miracle Urine Destroyer Plus Cat is a ready-to-use enzymatic cleaner designed specifically for cat urine stains and odors. Its enzymatic formula starts breaking down stains on contact and continues working as long as any organic residue remains, making it effective for deep cleaning and odor control. The product is applied by soaking the affected area, waiting 15 minutes, and then blotting it up, which makes it straightforward and convenient to use.

It is safe to use around pets and in the home when used as directed, providing peace of mind for households with multiple animals. The unscented formula helps avoid overwhelming fragrances while still addressing odors effectively. As a spray, it is easy to apply on carpets, floors, or other surfaces compatible with liquid cleaning. The product requires some drying time after application, so it may not deliver immediate results.

There is no specific information about the product's eco-friendliness, so customers who prioritize this aspect may want to investigate further. This cleaner is well-suited for pet owners seeking a reliable enzymatic solution to manage cat urine messes without complicated steps or harsh chemicals.

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
4626 reviews

Enzyme Type
The enzymatic formula starts working on contact and continues breaking down urine residues, ensuring deep, lasting cleaning.
Application Method
Safe and straightforward to use around pets and children, offering peace of mind in multi-animal households.
Surface Compatibility
Effectively removes tough cat urine stains and completely eliminates odors, even on challenging surfaces like mattresses.
Odor Control
Effectively removes tough cat urine stains and completely eliminates odors, even on challenging surfaces like mattresses.
Drying Time
Requires a 10-15 minute dwell time to fully neutralize odors; rushing this step can leave lingering smells.
Eco-Friendliness
Safe and straightforward to use around pets and children, offering peace of mind in multi-animal households.
#3

Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X Pro-Bacteria Cleaning Power | 1 Gallon , 128 Fl Oz (Pack of 1)

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
37655 reviews

Enzyme Type
The product prevents pets from returning to the same spot to pee, thanks to its strong enzyme formula.
Application Method
The solution sprays well with three different spray settings, making it versatile for various cleaning needs.
Surface Compatibility
Safe for use on multiple surfaces, it’s a reliable cleaner for homes with both pets and children.
Odor Control
The multipurpose spray is highly effective, with a pleasant, light powder scent that doesn't overpower.

The Simple Solution Extreme Pet Stain and Odor Remover is designed to be highly effective at dealing with pet messes, specifically cat urine. It boasts a formula that is three times stronger than its regular version, employing Pro-Bacteria and enzymes to break down and eliminate tough stains and odors. This can be particularly beneficial for households with pets prone to accidents, ensuring that odors and stains are thoroughly removed to discourage repeat marking.

The product is versatile in its application, being safe for use on a variety of water-safe surfaces including carpets, upholstery, bedding, fabric toys, and clothing. This broad surface compatibility means it can be a go-to cleaner for various areas in your home. Additionally, it is designed to be safe for both children and pets when used as directed, making it a family-friendly option for pet owners.

Despite these minor drawbacks, the Simple Solution Extreme Pet Stain and Odor Remover stands out as a potent and versatile cleaner that can effectively manage cat urine and other pet messes.

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
37655 reviews

Enzyme Type
The product prevents pets from returning to the same spot to pee, thanks to its strong enzyme formula.
Application Method
The solution sprays well with three different spray settings, making it versatile for various cleaning needs.
Surface Compatibility
Safe for use on multiple surfaces, it’s a reliable cleaner for homes with both pets and children.
Odor Control
The multipurpose spray is highly effective, with a pleasant, light powder scent that doesn't overpower.

Buying Guide for the Best Enzymatic Cleaners For Cat Urine

Choosing the right enzymatic cleaner for cat urine can make a significant difference in maintaining a clean and odor-free home. Enzymatic cleaners are specifically designed to break down the proteins in cat urine, eliminating both the stain and the odor. When selecting an enzymatic cleaner, it's important to consider several key specifications to ensure you get the best product for your needs. Understanding these specifications will help you make an informed decision and keep your home fresh and clean.
Enzyme TypeEnzyme type refers to the specific enzymes used in the cleaner to break down the urine. This is important because different enzymes target different components of the urine. Common enzymes include proteases, which break down proteins, and amylases, which break down starches. For cat urine, proteases are particularly effective. When choosing a cleaner, look for one that specifically mentions it targets pet urine or cat urine to ensure it contains the right enzymes.
Application MethodThe application method refers to how the cleaner is applied to the affected area. This can include spray bottles, pour bottles, or even powders. The method is important because it affects how easy and effective the cleaner is to use. Spray bottles are convenient for small spots and quick applications, while pour bottles might be better for larger areas or deep cleaning. Consider the size of the area you need to clean and how frequently you will use the product to determine the best application method for you.
Surface CompatibilitySurface compatibility indicates which surfaces the cleaner can be safely used on, such as carpets, hardwood floors, upholstery, or tile. This is crucial because using the wrong cleaner on a surface can cause damage. Check the product label to ensure it is safe for the surfaces you need to clean. If you have multiple types of surfaces, look for a versatile cleaner that works on various materials.
Odor ControlOdor control refers to the cleaner's ability to eliminate or neutralize odors, rather than just masking them. This is important for ensuring that the smell of cat urine is completely removed from your home. Some cleaners also include additional ingredients to leave a pleasant scent. If you are sensitive to fragrances or prefer a neutral smell, choose a product that focuses on odor elimination without added scents.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This is important because it affects how quickly you can use the cleaned area again. Fast-drying cleaners are convenient for busy households, while slower-drying options might be more thorough in breaking down stains and odors. Consider your schedule and how quickly you need the area to be usable when choosing a cleaner.
Eco-FriendlinessEco-friendliness refers to the environmental impact of the cleaner, including the ingredients used and the packaging. This is important for those who are environmentally conscious and want to reduce their ecological footprint. Look for cleaners that are biodegradable, non-toxic, and come in recyclable packaging. If sustainability is a priority for you, choose a product that aligns with your values.

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