10 Best Enzymatic Dog Toothpastes 2025 in the United States

The Virbac C.E.T. Enzymatic Toothpaste is designed to improve your pet's oral health by reducing plaque and freshening breath. Its enzyme-based formula, suitable for both dogs and cats, is effective in breaking down tartar and plaque, which contributes to better dental hygiene. The toothpaste comes in a vanilla mint flavor, which many pets seem to enjoy, making the brushing process easier for pet owners. One of the standout features of this toothpaste is its safety for daily use, as it contains no foaming agents and is safe for pets to swallow. Additionally, it is paraben-free, ensuring that your pet is not exposed to harmful chemicals.

Veterinary professionals highly recommend Virbac products, adding to its credibility and reliability in pet dental care. The toothpaste is packaged in a 2.5 oz tube, making it convenient to handle and store. Using it with a soft-bristled toothbrush, as suggested, enhances its effectiveness in cleaning your pet's teeth. However, some pet owners might find the vanilla mint flavor unusual for pet products, and it may not appeal to all pets. Furthermore, the need for a toothbrush might be seen as an additional step or expense.

The Virbac C.E.T. Enzymatic Toothpaste is a solid choice for pet owners looking to maintain their pet's oral hygiene with a vet-recommended, safe, and effective product.

Vet’s Best Enzymatic Dog Toothpaste is a specialized dental care product designed for dogs. It is formulated by veterinarians and contains a mix of enzymes, aloe, neem oil, grapefruit seed extract, and baking soda. These ingredients help in effectively cleaning teeth, removing plaque and tartar, and freshening breath. The soothing properties of aloe and neem oil are a plus for dogs with sensitive gums.

One notable feature is its banana flavor which many dogs seem to enjoy, making the tooth brushing experience more pleasant for them. Additionally, it is free from parabens, enhancing its safety profile for pets. The toothpaste comes in a gel form which is easy to apply either with a brush or directly with fingers. The updated packaging in a squeeze tube adds to the convenience of use.

However, some pet owners may find the requirement to avoid food and water 30 minutes before and after application a bit inconvenient. Another minor drawback is that the product needs to be used 2–3 times per week for optimal results, which requires a bit of commitment. Despite these minor inconveniences, its effectiveness and natural flavoring make it a strong candidate for maintaining your dog's dental hygiene.

Petsmile Professional Pet Toothpaste is a non-enzymatic option for cleaning your dog's teeth, which sets it apart since most dog toothpastes rely on enzymes. Its standout feature is the VOHC (Veterinary Oral Health Council) acceptance, indicating it meets high dental care standards. The toothpaste uses a proprietary formula called Calprox, which helps prevent plaque, tartar, and gingivitis while whitening teeth and improving gum health.

The London Broil flavor could be appealing to pets, making it easier to use. Additionally, it's formulated with human-grade, hypoallergenic, and high-quality ingredients, ensuring safety for your pet. One of its key strengths is the no-brush requirement, as you just need to apply it on your pet's teeth and let their tongue do the cleaning, ideal for pets who resist brushing.

As it is non-enzymatic, it might not be as effective as enzymatic toothpastes for certain pets. The packaging is practical, and the product is free from harmful substances like bisphenol A, sulfates, gluten, and parabens, making it a safe option. Veterinary dentists often recommend it, giving it further credibility. If your pet has specific dental needs or prefers certain flavors, this toothpaste could be a good fit despite the lack of enzymes.