10 Best Enzymatic Dog Toothpastes 2025 in the United States

The Virbac C.E.T. Enzymatic Toothpaste is designed to improve your pet's oral health by reducing plaque and freshening breath. Its enzyme-based formula, suitable for both dogs and cats, is effective in breaking down tartar and plaque, which contributes to better dental hygiene. The toothpaste comes in a vanilla mint flavor, which many pets seem to enjoy, making the brushing process easier for pet owners. One of the standout features of this toothpaste is its safety for daily use, as it contains no foaming agents and is safe for pets to swallow. Additionally, it is paraben-free, ensuring that your pet is not exposed to harmful chemicals.

Veterinary professionals highly recommend Virbac products, adding to its credibility and reliability in pet dental care. The toothpaste is packaged in a 2.5 oz tube, making it convenient to handle and store. Using it with a soft-bristled toothbrush, as suggested, enhances its effectiveness in cleaning your pet's teeth. However, some pet owners might find the vanilla mint flavor unusual for pet products, and it may not appeal to all pets. Furthermore, the need for a toothbrush might be seen as an additional step or expense.

The Virbac C.E.T. Enzymatic Toothpaste is a solid choice for pet owners looking to maintain their pet's oral hygiene with a vet-recommended, safe, and effective product.

Petsmile Professional Pet Toothpaste is a non-enzymatic option for cleaning your dog's teeth, which sets it apart since most dog toothpastes rely on enzymes. Its standout feature is the VOHC (Veterinary Oral Health Council) acceptance, indicating it meets high dental care standards. The toothpaste uses a proprietary formula called Calprox, which helps prevent plaque, tartar, and gingivitis while whitening teeth and improving gum health.

The London Broil flavor could be appealing to pets, making it easier to use. Additionally, it's formulated with human-grade, hypoallergenic, and high-quality ingredients, ensuring safety for your pet. One of its key strengths is the no-brush requirement, as you just need to apply it on your pet's teeth and let their tongue do the cleaning, ideal for pets who resist brushing.

As it is non-enzymatic, it might not be as effective as enzymatic toothpastes for certain pets. The packaging is practical, and the product is free from harmful substances like bisphenol A, sulfates, gluten, and parabens, making it a safe option. Veterinary dentists often recommend it, giving it further credibility. If your pet has specific dental needs or prefers certain flavors, this toothpaste could be a good fit despite the lack of enzymes.

Petrodex Enzymatic Dog Toothpaste is designed to help reduce plaque and tartar buildup while combating bad breath, making it a solid choice for maintaining your dog's oral hygiene. The toothpaste contains patented enzymes which make it effective at cleaning teeth without the need for rinsing. Its poultry flavor is generally well-liked by dogs, making brushing a more pleasant experience for them.

The toothpaste is paraben-free, ensuring safety for your pets, and it is suitable for dogs of all life stages. Its non-foaming formula adds to its ease of use, and consistent use (2-3 times per week) can yield noticeable improvements in your dog's dental health. The product comes in a 6.2-ounce tube, which is durable and easy to handle, though the tube might be large for those with smaller storage spaces.

The texture and consistency of the paste might be an acquired taste for some dogs, and its effectiveness may vary depending on the frequency and thoroughness of brushing. For best results, it's advisable to use a Petrodex toothbrush designed for pets. This toothpaste is manufactured in the USA and has been well-received in the market for nearly two decades.