10 Best Enzyme-Based Cleaners 2025 in the United States

Nature's Miracle Urine Destroyer Plus for Cats stands out as a dedicated solution for tackling severe cat urine stains. The enzymatic formula is designed to start breaking down and removing stains immediately on contact, making it very effective for urgent messes. A notable feature is its ability to continue working as long as bio-based messes are present, ensuring thorough cleaning over time.

The application is straightforward: simply soak the affected area, wait for 15 minutes, and then blot it up with a clean cloth, which makes it convenient for everyday use. This product is also eco-friendly, as the bottles are made from 25% post-consumer recycled material, which is a plus for environmentally conscious users. Additionally, it is safe for use around pets and in homes when used as directed, offering peace of mind for pet owners.

However, the product is unscented, which might be a downside for those who prefer a fresh smelling cleaner. Also, it comes in a spray form that might not be suitable for all types of surfaces, and the passive diffusion power source means it might not be as powerful in very large or heavily soiled areas. Despite these minor drawbacks, Nature's Miracle Urine Destroyer Plus is a reliable choice for cat owners needing an effective and eco-friendly solution for dealing with cat urine stains.

Nature's Miracle Urine Destroyer Plus for Dogs is an enzymatic cleaner designed specifically to tackle tough dog urine stains and odors. It starts working immediately on contact and continues breaking down organic messes as long as they remain, which is ideal for severe or older stains. The product comes ready to use in a 32-ounce spray bottle, making application straightforward—just soak, wait 15 minutes, and blot clean.

Its formula is safe for use around pets and homes when used as directed, giving peace of mind to dog owners. One notable eco-friendly aspect is the packaging made with 25% post-consumer recycled plastic, fitting well with environmentally conscious users. This cleaner is intended for indoor use and is well-regarded by many users.

This cleaner works best for dog owners dealing with noticeable urine stains who want a reliable, pet-safe, and easy-to-use enzymatic solution. It may be less suitable for users needing fragrance-free options or those wanting precise enzyme or surface compatibility details ahead of purchase.

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray is a specialized enzyme-based cleaner designed to tackle severe dog messes such as urine, diarrhea, and vomit. The enzymatic formula is particularly effective, as it continues to work as long as the bio-based mess is present, ensuring thorough cleaning. This spray is suitable for various surfaces, making it versatile for use around the home.

One of its standout features is its light, fresh scent, which helps to neutralize odors and leave your home smelling clean. Additionally, the product discourages resoiling by removing the associated odors, which can be a significant benefit for pet owners dealing with recurrent messes. It is important to note that it comes in a 32-ounce liquid sprayer form, which might require a bit of manual effort to use.

Despite these minor drawbacks, Nature’s Miracle remains a trusted brand in the pet stain and odor removal market, known for its reliable performance.