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10 Best Enzyme-Based Cleaners 2025 in the United States

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Our Top Picks

#1

Winner

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

Rating
9.8
Chosen by1,270
Surface Compatibility
Scent
Application Method

Most important from
15431 reviews

Surface Compatibility
Transforms carpets with high-traffic stains and pet odors, achieving results where other cleaners failed.
Scent
Pleasant mint scent enhances the cleaning experience and leaves areas smelling fresh.
Application Method
A lifesaver for stubborn odors and stains, making bedding and furniture smell fresh and look brand new after soaking.

The AmazonCommercial Multi-Purpose Enzyme Cleaner is a versatile cleaning solution suitable for various surfaces and environments, making it a good option for commercial properties, retail spaces, and hospitality settings. It comes in a substantial 1-gallon bottle, which should last for a significant amount of time, even with regular use.

One of its key strengths is its ability to break down complex organic materials like pet stains, hair, grease, and oils, making it highly effective for spot cleaning carpets, surfaces, drains, toilets, and grease traps. The cleaner is particularly beneficial for tackling slow drains and eliminating unpleasant odors, thanks to its enzyme-based formula that targets grease and fats. The mint scent is a pleasant touch, ensuring that cleaned areas smell fresh rather than chemically.

This enzyme cleaner is a powerful and versatile option for commercial and heavy-duty cleaning tasks.

Rating
9.8
Chosen by1,270
Surface Compatibility
Scent
Application Method

Most important from
15431 reviews

Surface Compatibility
Transforms carpets with high-traffic stains and pet odors, achieving results where other cleaners failed.
Scent
Pleasant mint scent enhances the cleaning experience and leaves areas smelling fresh.
Application Method
A lifesaver for stubborn odors and stains, making bedding and furniture smell fresh and look brand new after soaking.
#2

Nature's Miracle Advanced Dog Stain and Odor Eliminator Spray, Severe Mess Enzymatic Formula, 32 fl oz

Rating
9.6
Surface Compatibility
Scent

Most important from
22161 reviews

Surface Compatibility
Safe for use on various surfaces without causing discoloration or harm.
Scent
Strong initial scent that dissipates after a few hours; using a fan can help speed this up.

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray is a specialized enzyme-based cleaner designed to tackle severe dog messes such as urine, diarrhea, and vomit. The enzymatic formula is particularly effective, as it continues to work as long as the bio-based mess is present, ensuring thorough cleaning. This spray is suitable for various surfaces, making it versatile for use around the home.

One of its standout features is its light, fresh scent, which helps to neutralize odors and leave your home smelling clean. Additionally, the product discourages resoiling by removing the associated odors, which can be a significant benefit for pet owners dealing with recurrent messes. It is important to note that it comes in a 32-ounce liquid sprayer form, which might require a bit of manual effort to use.

Despite these minor drawbacks, Nature’s Miracle remains a trusted brand in the pet stain and odor removal market, known for its reliable performance.

Rating
9.6
Surface Compatibility
Scent

Most important from
22161 reviews

Surface Compatibility
Safe for use on various surfaces without causing discoloration or harm.
Scent
Strong initial scent that dissipates after a few hours; using a fan can help speed this up.
#3

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

Rating
9.4
Surface Compatibility
Application Method

Most important from
2611 reviews

Surface Compatibility
The spray worked great on a firm mattress, removing both stain and smell completely.
Application Method
To fully neutralize the odor, it's crucial to let the product sit for 10-15 minutes.

Nature's Miracle Urine Destroyer Plus for Cats stands out as a dedicated solution for tackling severe cat urine stains. The enzymatic formula is designed to start breaking down and removing stains immediately on contact, making it very effective for urgent messes. A notable feature is its ability to continue working as long as bio-based messes are present, ensuring thorough cleaning over time.

The application is straightforward: simply soak the affected area, wait for 15 minutes, and then blot it up with a clean cloth, which makes it convenient for everyday use. This product is also eco-friendly, as the bottles are made from 25% post-consumer recycled material, which is a plus for environmentally conscious users. Additionally, it is safe for use around pets and in homes when used as directed, offering peace of mind for pet owners.

However, the product is unscented, which might be a downside for those who prefer a fresh smelling cleaner. Also, it comes in a spray form that might not be suitable for all types of surfaces, and the passive diffusion power source means it might not be as powerful in very large or heavily soiled areas. Despite these minor drawbacks, Nature's Miracle Urine Destroyer Plus is a reliable choice for cat owners needing an effective and eco-friendly solution for dealing with cat urine stains.

Rating
9.4
Surface Compatibility
Application Method

Most important from
2611 reviews

Surface Compatibility
The spray worked great on a firm mattress, removing both stain and smell completely.
Application Method
To fully neutralize the odor, it's crucial to let the product sit for 10-15 minutes.

Buying Guide for the Best Enzyme-Based Cleaners

Enzyme-based cleaners are a great choice for tackling tough stains and odors, especially those caused by organic materials like food, pet accidents, and bodily fluids. These cleaners use natural enzymes to break down the molecules in stains and odors, making them easier to remove. When choosing an enzyme-based cleaner, it's important to consider several key specifications to ensure you get the best product for your needs.
Type of EnzymesEnzyme-based cleaners can contain different types of enzymes, such as proteases, lipases, and amylases. Proteases break down proteins, making them effective for blood, food, and pet stains. Lipases target fats and oils, while amylases work on starches and carbohydrates. Understanding the type of stain you need to remove will help you choose a cleaner with the appropriate enzymes. For example, if you have a lot of pet stains, a cleaner with proteases would be ideal.
Surface CompatibilityNot all enzyme-based cleaners are suitable for every surface. Some are designed specifically for fabrics, while others are meant for hard surfaces like tile or wood. It's important to check the label to ensure the cleaner is safe for the surface you intend to use it on. If you need a versatile cleaner, look for one that is labeled as multi-surface or all-purpose.
ConcentrationThe concentration of enzymes in a cleaner can affect its effectiveness. Higher concentrations typically mean more powerful cleaning action, but they may also require dilution before use. If you have heavy-duty cleaning needs, a more concentrated formula might be best. For everyday cleaning, a less concentrated, ready-to-use formula could be more convenient.
ScentEnzyme-based cleaners can come with various scents or be unscented. If you are sensitive to fragrances or prefer a neutral smell, an unscented cleaner might be the best choice. On the other hand, if you enjoy a fresh scent after cleaning, look for a product with a fragrance you like. Just be aware that some scented cleaners may contain additional chemicals that could affect people with allergies or sensitivities.
Eco-FriendlinessMany enzyme-based cleaners are marketed as eco-friendly because they use natural enzymes and are biodegradable. However, it's important to check for certifications or labels that confirm the product's environmental claims. If sustainability is important to you, look for cleaners that are free from harsh chemicals, have recyclable packaging, and are certified by reputable environmental organizations.
Application MethodEnzyme-based cleaners can come in various forms, such as sprays, powders, or liquids. Sprays are convenient for quick spot cleaning, while powders and liquids might be better for larger areas or deep cleaning. Consider how you plan to use the cleaner and choose the application method that fits your needs. For example, a spray might be ideal for small, frequent messes, while a liquid concentrate could be more economical for regular, extensive cleaning.

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