10 Best Enzyme-Based Cleaners 2026 in the United States

The AmazonCommercial Multi-Purpose Enzyme Cleaner is a versatile cleaning solution suitable for various surfaces and environments, making it a good option for commercial properties, retail spaces, and hospitality settings. It comes in a substantial 1-gallon bottle, which should last for a significant amount of time, even with regular use.

One of its key strengths is its ability to break down complex organic materials like pet stains, hair, grease, and oils, making it highly effective for spot cleaning carpets, surfaces, drains, toilets, and grease traps. The cleaner is particularly beneficial for tackling slow drains and eliminating unpleasant odors, thanks to its enzyme-based formula that targets grease and fats. The mint scent is a pleasant touch, ensuring that cleaned areas smell fresh rather than chemically.

This enzyme cleaner is a powerful and versatile option for commercial and heavy-duty cleaning tasks.

Nature's Miracle Dog Stain and Odor Remover is an enzymatic cleaner designed to tackle everyday pet messes. The enzymatic formula is a strong point, as it continues to work on stains and odors as long as the bio-based mess is present, ensuring thorough cleaning. It's compatible with various surfaces around the home, making it versatile.

The light citrus scent helps to mask any unpleasant odors, leaving your home smelling fresh. One downside is that the citrus scent may not appeal to everyone, especially those sensitive to fragrances. The product is eco-friendly and safe for use around pets when used as directed, which is a significant advantage for pet owners concerned about safety.

The spray application method is straightforward and user-friendly. However, the concentration might require multiple applications for tougher stains, which could be a minor inconvenience. While it's marketed as a trusted brand, individual experiences may vary. Nature's Miracle Dog Stain and Odor Remover is an effective, pet-safe option for managing everyday pet stains and odors with some minor considerations.

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray is a specialized enzyme-based cleaner designed to tackle severe dog messes such as urine, diarrhea, and vomit. The enzymatic formula is particularly effective, as it continues to work as long as the bio-based mess is present, ensuring thorough cleaning. This spray is suitable for various surfaces, making it versatile for use around the home.

One of its standout features is its light, fresh scent, which helps to neutralize odors and leave your home smelling clean. Additionally, the product discourages resoiling by removing the associated odors, which can be a significant benefit for pet owners dealing with recurrent messes. It is important to note that it comes in a 32-ounce liquid sprayer form, which might require a bit of manual effort to use.

Despite these minor drawbacks, Nature’s Miracle remains a trusted brand in the pet stain and odor removal market, known for its reliable performance.