10 Best Enzyme-Based Cleaners 2025 in the United States

The AmazonCommercial Multi-Purpose Enzyme Cleaner is a versatile cleaning solution suitable for various surfaces and environments, making it a good option for commercial properties, retail spaces, and hospitality settings. It comes in a substantial 1-gallon bottle, which should last for a significant amount of time, even with regular use.

One of its key strengths is its ability to break down complex organic materials like pet stains, hair, grease, and oils, making it highly effective for spot cleaning carpets, surfaces, drains, toilets, and grease traps. The cleaner is particularly beneficial for tackling slow drains and eliminating unpleasant odors, thanks to its enzyme-based formula that targets grease and fats. The mint scent is a pleasant touch, ensuring that cleaned areas smell fresh rather than chemically.

This enzyme cleaner is a powerful and versatile option for commercial and heavy-duty cleaning tasks.

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray is a specialized enzyme-based cleaner designed to tackle severe dog messes such as urine, diarrhea, and vomit. The enzymatic formula is particularly effective, as it continues to work as long as the bio-based mess is present, ensuring thorough cleaning. This spray is suitable for various surfaces, making it versatile for use around the home.

One of its standout features is its light, fresh scent, which helps to neutralize odors and leave your home smelling clean. Additionally, the product discourages resoiling by removing the associated odors, which can be a significant benefit for pet owners dealing with recurrent messes. It is important to note that it comes in a 32-ounce liquid sprayer form, which might require a bit of manual effort to use.

Despite these minor drawbacks, Nature’s Miracle remains a trusted brand in the pet stain and odor removal market, known for its reliable performance.

Nature's Miracle Urine Destroyer Plus for Cats stands out as a dedicated solution for tackling severe cat urine stains. The enzymatic formula is designed to start breaking down and removing stains immediately on contact, making it very effective for urgent messes. A notable feature is its ability to continue working as long as bio-based messes are present, ensuring thorough cleaning over time.

The application is straightforward: simply soak the affected area, wait for 15 minutes, and then blot it up with a clean cloth, which makes it convenient for everyday use. This product is also eco-friendly, as the bottles are made from 25% post-consumer recycled material, which is a plus for environmentally conscious users. Additionally, it is safe for use around pets and in homes when used as directed, offering peace of mind for pet owners.

However, the product is unscented, which might be a downside for those who prefer a fresh smelling cleaner. Also, it comes in a spray form that might not be suitable for all types of surfaces, and the passive diffusion power source means it might not be as powerful in very large or heavily soiled areas. Despite these minor drawbacks, Nature's Miracle Urine Destroyer Plus is a reliable choice for cat owners needing an effective and eco-friendly solution for dealing with cat urine stains.