10 Best Enzyme-Based Cleaners 2025 in the United States

Nature's Miracle Urine Destroyer Plus for Dogs is an enzymatic cleaner designed specifically to tackle tough dog urine stains and odors. It starts working immediately on contact and continues breaking down organic messes as long as they remain, which is ideal for severe or older stains. The product comes ready to use in a 32-ounce spray bottle, making application straightforward—just soak, wait 15 minutes, and blot clean.

Its formula is safe for use around pets and homes when used as directed, giving peace of mind to dog owners. One notable eco-friendly aspect is the packaging made with 25% post-consumer recycled plastic, fitting well with environmentally conscious users. This cleaner is intended for indoor use and is well-regarded by many users.

This cleaner works best for dog owners dealing with noticeable urine stains who want a reliable, pet-safe, and easy-to-use enzymatic solution. It may be less suitable for users needing fragrance-free options or those wanting precise enzyme or surface compatibility details ahead of purchase.

Nature’s Miracle Advanced Stain and Odor Eliminator Dog Spray is a specialized enzyme-based cleaner designed to tackle severe dog messes such as urine, diarrhea, and vomit. The enzymatic formula is particularly effective, as it continues to work as long as the bio-based mess is present, ensuring thorough cleaning. This spray is suitable for various surfaces, making it versatile for use around the home.

One of its standout features is its light, fresh scent, which helps to neutralize odors and leave your home smelling clean. Additionally, the product discourages resoiling by removing the associated odors, which can be a significant benefit for pet owners dealing with recurrent messes. It is important to note that it comes in a 32-ounce liquid sprayer form, which might require a bit of manual effort to use.

Despite these minor drawbacks, Nature’s Miracle remains a trusted brand in the pet stain and odor removal market, known for its reliable performance.

Nature's Miracle Dog Stain and Odor Remover is an enzymatic cleaner designed to tackle everyday pet messes. The enzymatic formula is a strong point, as it continues to work on stains and odors as long as the bio-based mess is present, ensuring thorough cleaning. It's compatible with various surfaces around the home, making it versatile.

The light citrus scent helps to mask any unpleasant odors, leaving your home smelling fresh. One downside is that the citrus scent may not appeal to everyone, especially those sensitive to fragrances. The product is eco-friendly and safe for use around pets when used as directed, which is a significant advantage for pet owners concerned about safety.

The spray application method is straightforward and user-friendly. However, the concentration might require multiple applications for tougher stains, which could be a minor inconvenience. While it's marketed as a trusted brand, individual experiences may vary. Nature's Miracle Dog Stain and Odor Remover is an effective, pet-safe option for managing everyday pet stains and odors with some minor considerations.