10 Best Enzyme Cleaners For Dog Urine 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a versatile enzyme cleaner designed for removing dog urine and other pet-related stains and odors. Its high enzyme concentration effectively breaks down ammonia crystals and organic matter, ensuring thorough cleaning and odor elimination. The product is certified safe for use around pets and children, making it a reliable choice for households with furry friends.

It works on a variety of surfaces including carpets, floors, furniture, and pet living areas, providing a comprehensive cleaning solution. Eco-conscious users will appreciate that it is chlorine-free, color-safe, and leaves no hazardous residue. The original scent is mild and non-overpowering. The cleaner is straightforward to use, requiring a simple spray on the affected area and some drying time, which can vary depending on the surface and stain severity.

The 128 Fl Oz size might be cumbersome for some users to handle due to its weight. Additionally, its relatively high cost may be a consideration for budget-conscious consumers. This product is best suited for pet owners looking for an efficient, eco-friendly cleaning solution that is safe for both their animals and their household.

The ANGRY ORANGE Pet Odor Eliminator is designed to tackle pet urine and other unpleasant smells, specifically targeting cat urine. The product comes in a 24 oz spray bottle with a fresh orange scent, making it pleasant to use and effective in masking odors. One of its strengths is the ease of use due to its spray form, which requires no additional setup or mixing. Simply spray the affected area and let the formula work its magic.

It's also noteworthy that the product has a responsive customer service team to address any dissatisfaction, ensuring a satisfactory user experience. Surface compatibility is another important aspect, and while the product is generally safe for various surfaces, users should test it on a small hidden area first to avoid any damage. The fresh scent is a significant plus for those sensitive to strong chemicals, but it might not completely eliminate the odor for everyone, depending on the severity of the issue.

This product is best suited for pet owners dealing with recurring odor issues and those who prefer a simple and pleasant-smelling solution.

Nature’s Miracle Advanced Stain And Odor Eliminator for Dogs is a popular choice for tackling severe pet messes. Its high enzyme concentration ensures robust cleaning power, making it effective at removing tough stains and odors. This product works on a variety of surfaces, including carpets, hard floors, furniture, and even clothing, which adds to its versatility. The fast-drying formula is a plus, as it means the cleaned areas can be used again quickly. Additionally, the light fresh scent helps in keeping your home smelling pleasant after cleaning sessions.

Eco-conscious users will appreciate that it is made in the USA. The product’s ease of use is generally well received, allowing users to simply apply and let it work its magic. However, the 1-gallon size may be cumbersome for some users to handle, and the weight of 8 pounds could be a drawback for those looking for a more portable solution. While the product is effective at discouraging re-soiling by removing the odor entirely, it might be worth noting that the fresh scent, while light, may not appeal to everyone.

Nature’s Miracle Advanced Stain And Odor Eliminator stands out as a strong contender in the enzyme cleaners category, particularly for households dealing with severe pet messes on various surfaces.