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10 Best Enzyme Laundry Detergents 2025 in the United States

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Our Top Picks

#1

Winner

Tide PODS Laundry Detergent Pacs, 3-in-1 Stain Remover, Odor Fighter, Color Protector, 112 Count, HE compatible, Original Scent

Rating
10.0
Chosen by1,304
Form (Liquid, Powder, Pods)
Scent
Compatibility with Washing Machines

Most important from
275196 reviews

Form (Liquid, Powder, Pods)
Tide PODS are a game-changer for laundry—easy to use, highly effective, and perfect for busy households.
Scent
The Spring Meadow fragrance is fresh but not overpowering, leaving clothes smelling clean without being too strong.
Compatibility with Washing Machines
They’re compatible with both high-efficiency and standard washers, and they dissolve well in both hot and cold water.

The Tide PODS Laundry Detergent Pacs in Spring Meadow Scent offer a powerful and convenient solution for laundry needs. These pods are designed to provide a 3-in-1 cleaning action: concentrated detergent, odor removal, and stain removal. This makes them particularly effective for tackling tough stains and maintaining vibrant colors in your clothes.

The pods dissolve completely in any water condition, ensuring that your clothes are thoroughly cleaned every wash, and they are compatible with all types of washing machines, adding to their versatility. The ease of use is a highlight, especially for those who prefer a mess-free laundry experience with pre-measured doses of detergent.

Rating
10.0
Chosen by1,304
Form (Liquid, Powder, Pods)
Scent
Compatibility with Washing Machines

Most important from
275196 reviews

Form (Liquid, Powder, Pods)
Tide PODS are a game-changer for laundry—easy to use, highly effective, and perfect for busy households.
Scent
The Spring Meadow fragrance is fresh but not overpowering, leaving clothes smelling clean without being too strong.
Compatibility with Washing Machines
They’re compatible with both high-efficiency and standard washers, and they dissolve well in both hot and cold water.
#2

Tide Liquid Laundry Detergent, HE Compatible, Original Scent, 80 loads, 105 fl oz

Rating
8.8
Scent
Compatibility with Washing Machines

Most important from
66161 reviews

Scent
The fresh, clean scent is long-lasting yet subtle, keeping laundry smelling great days after washing.
Compatibility with Washing Machines
Compatible with high-efficiency washers, it supports energy and water savings without leaving excess detergent residue.

Tide Liquid Laundry Detergent is a well-known and trusted choice for many households, especially since it's compatible with high-efficiency (HE) washers, which helps save water and energy. It comes in a large 105-ounce liquid form, making measuring easy with the cap provided—helpful for avoiding waste. The detergent is infused with Tide’s Original Scent, a fresh and floral fragrance that many users enjoy. It highlights its ability to clean deeply, whiten, brighten, and freshen clothes.

Being suds-free and suitable for HE machines, it fits well for modern washers that need low-sudsing detergents. This detergent is ideal for users wanting a reliable, easy-to-use liquid detergent with a fresh scent and compatibility with HE machines.

Rating
8.8
Scent
Compatibility with Washing Machines

Most important from
66161 reviews

Scent
The fresh, clean scent is long-lasting yet subtle, keeping laundry smelling great days after washing.
Compatibility with Washing Machines
Compatible with high-efficiency washers, it supports energy and water savings without leaving excess detergent residue.
#3

ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 128 Loads Liquid Laundry Detergent, 166.5 Fl oz

Rating
7.6
Scent

Most important from
31050 reviews

Scent
Works well, smells fresh, and leaves laundry very clean.

Arm & Hammer Plus OxiClean Odor Blasters Fresh Burst Liquid Laundry Detergent is a versatile option that promises to tackle tough odors and stains effectively. One of its standout features is the inclusion of OxiClean Stain Fighters, known for their powerful stain removal capabilities, particularly for stubborn stains such as food, grass, and grease. Additionally, the detergent contains ARM & HAMMER Baking Soda, enhancing its ability to neutralize odors and ensure lasting freshness with a pleasant Fresh Burst scent. This makes it a good choice for those dealing with strong body odors, sweat, or musty towels.

The liquid form of this detergent is convenient for measuring and using in both high-efficiency (HE) and traditional washing machines, ensuring compatibility across different types of washers. The bottle size is quite large, providing enough detergent for up to 128 medium loads, which is economical for households with frequent laundry needs. On the environmental front, the detergent is free from phosphates, ammonia, bleach, and aluminum, making it a relatively eco-friendly choice.

The product's performance in stain and odor removal, along with its user-friendly liquid form and fresh scent, make it a strong contender in the enzyme laundry detergent category.

Rating
7.6
Scent

Most important from
31050 reviews

Scent
Works well, smells fresh, and leaves laundry very clean.

Buying Guide for the Best Enzyme Laundry Detergents

Choosing the right enzyme laundry detergent can make a significant difference in how clean and fresh your clothes come out of the wash. Enzyme detergents are specially formulated to break down various types of stains and soils, making them highly effective for a wide range of laundry needs. To pick the best enzyme laundry detergent for you, it's important to understand the key specifications and how they align with your laundry requirements.
Types of EnzymesEnzyme detergents often contain different types of enzymes such as proteases, amylases, lipases, and cellulases. Proteases break down protein-based stains like blood and sweat, amylases target starches, lipases dissolve fats and oils, and cellulases help in removing dirt and maintaining fabric integrity. Knowing the types of stains you frequently encounter can help you choose a detergent with the right combination of enzymes.
ConcentrationThe concentration of enzymes in a detergent determines its effectiveness. Higher concentrations can tackle tougher stains more efficiently but may also be harsher on delicate fabrics. If you have heavily soiled clothes, a high-concentration detergent might be best. For everyday laundry or delicate items, a lower concentration may suffice.
Form (Liquid, Powder, Pods)Enzyme detergents come in various forms such as liquid, powder, and pods. Liquid detergents are great for pre-treating stains and dissolving quickly in water. Powder detergents are often more cost-effective and have a longer shelf life. Pods are convenient and pre-measured, reducing the risk of using too much detergent. Your choice depends on your laundry habits and convenience preferences.
ScentThe scent of a detergent can enhance the freshness of your clothes. Some people prefer strong, lasting fragrances, while others may opt for mild or unscented options due to sensitivities or personal preference. Consider your scent preference and any potential allergies when choosing a detergent.
Compatibility with Washing MachinesEnsure that the enzyme detergent you choose is compatible with your washing machine, whether it's a high-efficiency (HE) model or a standard one. HE detergents are formulated to produce fewer suds and are more efficient in water usage, making them ideal for HE machines. Using the wrong type of detergent can affect the performance of your washing machine.
Environmental ImpactSome enzyme detergents are formulated to be eco-friendly, using biodegradable ingredients and minimal packaging. If environmental sustainability is important to you, look for detergents that are labeled as eco-friendly or have certifications from reputable environmental organizations.

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