10 Best Enzyme Pet Cleaners 2025 in the United States

The ANGRY ORANGE Pet Odor Eliminator is designed to tackle tough pet odors with a powerful citrus scent derived from fresh orange peels. One of its major strengths is its effectiveness; a small amount can target and destroy strong, lingering smells at their source, making it a great option for pet owners facing persistent odor issues. This product is ready to use straight from the bottle, which means there's no need for mixing or diluting, adding to its convenience.

Application is straightforward: simply shake well, spray on the affected area, and let it dry completely. However, it's important to note that pets should be removed from the area during application, and the product should not be used directly on pets or in diffusers, as it can be too strong for cats and birds due to concentrated ingredients. The citrus scent is pleasant and helps mask unpleasant odors, making the environment more enjoyable.

In terms of versatility, it can be used on various surfaces like carpets, tiles, upholstery, and even in garbage cans and car interiors. This makes it a multipurpose cleaner beyond just pet-related messes. The ANGRY ORANGE Pet Odor Eliminator is an effective and versatile option for tackling pet odors, though users should be mindful of its concentrated nature and ensure it's used as directed.

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a versatile enzyme pet cleaner designed for removing tough stains and odors from various surfaces. It uses natural enzymes that activate on contact with stains and odors, effectively breaking down ammonia crystals and organic matter. This makes it a strong choice for tackling pet accidents like urine, feces, and vomit.

The product is certified gentle and safe, chlorine-free, and leaves no residue, which is a big plus for households with children and multiple pets. It is also color-safe and approved by the Carpet and Rug Institute, ensuring it won't damage your carpets. The cleaner is suitable for a wide range of surfaces, including carpets, floors, furniture, and even pet living areas like kennels and litter boxes, making it highly versatile.

However, its original scent may not appeal to everyone, and the drying time can vary depending on the surface and the amount used. Additionally, while it is eco-friendly in terms of being chemical-free, it does come in a plastic bottle, which may be a concern for environmentally conscious buyers. The product is backed by a satisfaction guarantee, providing peace of mind for users who want to ensure they are getting value for their money.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is designed as a professional-strength solution for removing pet stains and odors, as well as for deodorizing trash cans, drains, floors, and bathrooms. It uses probiotic enzymes, which are natural and effective at breaking down organic stains and odors, making it a solid choice for pet owners looking to tackle tough messes gently. The lemon scent adds a fresh, pleasant aroma without being overpowering.

As a liquid form, it’s easy to apply with common tools like spray bottles or mops. Its compatibility with various surfaces such as floors and bathrooms suggests versatility, though testing on delicate surfaces is advisable. The product is biobased, indicating eco-friendliness, which is a plus for environmentally conscious users. The gallon-sized container is suitable for frequent or large area use, although it may be bulky for smaller households.

This cleaner represents a strong option for pet owners or anyone needing a natural, multi-surface enzyme cleaner with a fresh scent, while users should ensure surface compatibility before use.