10 Best Acne Supplements 2025 in the United States

Nutrafol Clear Skin Acne Supplement is formulated specifically for women experiencing mild to moderate acne. One of its main strengths is its approach to treating acne from within by targeting multiple root causes, including stress and hormonal changes. This holistic method may appeal to those looking for a comprehensive solution rather than just a topical treatment. The supplement contains a blend of vegan ingredients, such as Holy Basil, Maca, and Berberine, which are known for their beneficial effects on skin health.

On the downside, the requirement to take four capsules daily may be a drawback for some users, as it can be seen as inconvenient or overwhelming. Results vary from person to person; while many report improvements, some may not see significant changes within the 4-12 week timeframe. Additionally, as with any supplement, there may be individual reactions to the ingredients, so it's essential for users to check the allergen information carefully.

Nutrafol's Clear Skin Supplement is a solid choice for women seeking a vegan, holistic approach to clearer skin, but it may not be for everyone due to the dosage and variability in results. It's particularly beneficial for those who want to address underlying issues contributing to acne rather than just treating the symptoms.

The HUM Daily Cleanse Acne Supplement offers a comprehensive approach to supporting clear skin through its blend of detoxifying ingredients. With 60 capsules per bottle, this supplement focuses on promoting gut health, which is increasingly recognized as vital for skin clarity. It features a variety of natural components such as spirulina, chlorella, and zinc, aiming to reduce breakouts and improve skin appearance over time.

One of the standout features is its commitment to quality. HUM products are Clean Label Project Certified, ensuring they are non-GMO and free from artificial additives. This purity may appeal to health-conscious consumers looking for trustworthy supplements. Additionally, the capsules are gluten-free, accommodating those with dietary restrictions.

There are a few considerations to keep in mind. As with many supplements, results can vary from person to person, and the effectiveness may depend on individual skin issues and overall health. Some users might also find it challenging to remember to take the capsules daily, which is essential for achieving the best results. Furthermore, the price point may be higher compared to other acne solutions, which could be a barrier for some.

HUM Daily Cleanse is a solid choice for individuals seeking a holistic supplement aimed at improving skin health through detoxification and gut support. It's especially suitable for those who prefer natural ingredients and are looking to integrate supplements into their wellness routine. However, potential users should consider their specific skin needs and budget before making a purchase.

CLEARSTEM - MINDBODYSKIN is a natural acne supplement designed to tackle hormonal acne from multiple angles. It combines ingredients like DIM, Vitamin B5, Vitamin A, glutathione, turmeric, milk thistle, and digestive enzymes, which support hormone balance, digestion, detoxification, and skin health. The supplement comes in vegan capsules, making it suitable for those avoiding animal products and common allergens like gluten.

The recommended dosage is 2-3 capsules with meals, which is important to follow to avoid stomach discomfort. Many users appreciate that it addresses stress and PMS-related acne alongside typical oil and blemish causes. While it promises noticeable skin improvement within 7-10 days, effects may vary, and it’s not suitable for pregnant or breastfeeding women. The product is free from hormone disruptors and pore-clogging ingredients, which is a plus for sensitive skin.

Taking multiple capsules daily and waiting for gradual results may require some patience. This supplement suits adults seeking a holistic, natural approach to hormonal acne and skin clarity, especially those looking for vegan and cruelty-free options.