10 Best Acne Supplements 2025 in the United States

CLEARSTEM MINDBODYSKIN is a natural acne supplement designed to tackle hormonal breakouts by addressing multiple factors like oil production, digestion, stress, and hormone balance. It comes in capsule form with 180 servings, providing a longer supply. The formula includes ingredients such as DIM, Vitamin B5, Vitamin A, Glutathione, Turmeric, Milk Thistle, and digestive enzymes—all known for supporting skin health, detoxification, and hormonal regulation. This combination aims to clear acne from the inside out while also uplifting mood and boosting immunity, making it suitable for various skin types.

Dosage is straightforward but requires taking 2-3 capsules with meals, which some might find more than single-capsule supplements. The product is gluten-free and cruelty-free, and it avoids pore-clogging agents and hormone disruptors, which is beneficial for sensitive skin. It is not recommended for pregnant or breastfeeding women. The brand promises noticeable improvements in skin clarity within 7-10 days, though results can vary among individuals.

A potential drawback is the relatively large capsule count per serving and the need to take multiple capsules daily, which might not fit everyone's routine. While the ingredients support detoxification and hormone balance, some users may require more targeted treatments if their acne is severe or caused by different factors. Customer reviews often highlight a calming effect and clearer skin, but note that consistent use over several weeks is typically necessary to achieve good results. If you seek a natural, multi-action supplement supporting hormonal balance and skin health, CLEARSTEM MINDBODYSKIN offers a thoughtful blend of ingredients and a comprehensive approach. Consultation with a healthcare provider is advised if pregnant or nursing.

The Clear Skin Acne Supplement by SMNutrition is designed to support clearer skin through a three-pronged approach: balancing hormones, improving gut health, and supplying key skin nutrients. Its main active ingredient is DIM (diindolylmethane), which helps regulate hormones often linked to acne flare-ups. It also contains probiotics (18 billion CFU of Lactobacillus and Bifidobacterium strains), which can promote a healthy gut microbiome—a factor increasingly recognized for skin health. Additionally, the formula includes zinc, hyaluronic acid, niacinamide, selenium, and vitamin B6, all known to aid hydration, skin repair, and controlling excess oil.

The supplement comes in capsule form, with 180 capsules providing a 60-day supply, making it convenient to use. It is made in the USA under cGMP guidelines and undergoes third-party testing, which speaks well for its quality and purity. Customer reviews generally praise its effectiveness in reducing breakouts and improving skin texture over time, though some users note that results can take several weeks to appear.

This supplement is a suitable option for both men and women seeking a natural, multi-faceted approach to hormonal and gut-related acne, especially for those who prefer capsules and value third-party tested products.

The jane iredale Advanced Nutrition Programme Skin Accumax Supplement is designed to support clearer, healthier skin, particularly for those dealing with non-cystic acne and general problem skin. It comes in a 60-day supply and is suitable for all skin types, making it accessible for many users. Manufactured in the UK under strict quality controls (cGMP certified) and FDA registered, it reflects a strong commitment to purity and safety.

Additionally, the product is not tested on animals, which may appeal to ethically minded buyers. If you are looking for a supplement to complement your skincare routine and prefer products with high manufacturing standards, this could be a good option.