10 Best Acne Supplements 2026 in the United States

The Clear Skin Acne Supplement by SMNutrition is designed to support clearer skin through a three-pronged approach: balancing hormones, improving gut health, and supplying key skin nutrients. Its main active ingredient is DIM (diindolylmethane), which helps regulate hormones often linked to acne flare-ups. It also contains probiotics (18 billion CFU of Lactobacillus and Bifidobacterium strains), which can promote a healthy gut microbiome—a factor increasingly recognized for skin health. Additionally, the formula includes zinc, hyaluronic acid, niacinamide, selenium, and vitamin B6, all known to aid hydration, skin repair, and controlling excess oil.

The supplement comes in capsule form, with 180 capsules providing a 60-day supply, making it convenient to use. It is made in the USA under cGMP guidelines and undergoes third-party testing, which speaks well for its quality and purity. Customer reviews generally praise its effectiveness in reducing breakouts and improving skin texture over time, though some users note that results can take several weeks to appear.

This supplement is a suitable option for both men and women seeking a natural, multi-faceted approach to hormonal and gut-related acne, especially for those who prefer capsules and value third-party tested products.

CLEARSTEM - MINDBODYSKIN is a natural acne supplement designed to tackle hormonal acne from multiple angles. It combines ingredients like DIM, Vitamin B5, Vitamin A, glutathione, turmeric, milk thistle, and digestive enzymes, which support hormone balance, digestion, detoxification, and skin health. The supplement comes in vegan capsules, making it suitable for those avoiding animal products and common allergens like gluten.

The recommended dosage is 2-3 capsules with meals, which is important to follow to avoid stomach discomfort. Many users appreciate that it addresses stress and PMS-related acne alongside typical oil and blemish causes. While it promises noticeable skin improvement within 7-10 days, effects may vary, and it’s not suitable for pregnant or breastfeeding women. The product is free from hormone disruptors and pore-clogging ingredients, which is a plus for sensitive skin.

Taking multiple capsules daily and waiting for gradual results may require some patience. This supplement suits adults seeking a holistic, natural approach to hormonal acne and skin clarity, especially those looking for vegan and cruelty-free options.

The jane iredale Advanced Nutrition Programme Skin Accumax Supplement is designed to support clearer, healthier skin, particularly for those dealing with non-cystic acne and general problem skin. It comes in a 60-day supply and is suitable for all skin types, making it accessible for many users. Manufactured in the UK under strict quality controls (cGMP certified) and FDA registered, it reflects a strong commitment to purity and safety.

Additionally, the product is not tested on animals, which may appeal to ethically minded buyers. If you are looking for a supplement to complement your skincare routine and prefer products with high manufacturing standards, this could be a good option.