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10 Best Anti Anxiety Supplement For Dogs 2025 in the United States

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Our Top Picks

#1

Winner

Zesty Paws Calming Chews for Dogs - for Everyday Stress, Relaxation, Composure, and Separation, 90 Count, Turkey - Melatonin

Rating
9.8
Chosen by1,427
Effectiveness

Most important from
27331 reviews

Effectiveness
These calming bites have been a lifesaver for our household, reducing anxiety and hyperactivity to the point where we can leave our dog home overnight without worry.

Zesty Paws Calming Chews for Dogs are designed to help manage everyday stress and hyperactivity in dogs, making them a good option for keeping pets calm during stressful situations like fireworks, storms, or car rides. These chews contain clinically studied ingredients such as Suntheanine (a premium form of L-Theanine) and Ashwagandha, which promote relaxation and calmness. Additionally, they include Valerian Root, Organic Seed Powder, Magnesium Citrate, L-Tryptophan, Organic Ginger Root, and Organic Passionflower, all known for their calming effects.

The chews come in a turkey flavor, which is generally appealing to dogs, and are suitable for all breeds and life stages, making them versatile. One pack contains 90 chews, which is a convenient quantity for regular use. The chews contain melatonin, which can have varying effects on different dogs, so it's best to consult with a vet before prolonged use. The chews are relatively safe but always monitor your dog's reaction when introducing a new supplement.

The duration of the calming effect can vary, but they are generally effective for a few hours, making them suitable for short-term stress relief. These chews are a solid choice for dog owners looking to manage their pet's anxiety in a natural and convenient way.

Rating
9.8
Chosen by1,427
Effectiveness

Most important from
27331 reviews

Effectiveness
These calming bites have been a lifesaver for our household, reducing anxiety and hyperactivity to the point where we can leave our dog home overnight without worry.
#2

Purina Pro Plan Veterinary Supplements Calming Care - Calming Dog Supplements - 30 ct. Boxes

Rating
9.6
Effectiveness
Duration of Effect

Most important from
2339 reviews

Effectiveness
This supplement works wonders for high-anxiety dogs, making them noticeably calmer and more relaxed.
Duration of Effect
Noticeable improvement in behavior can be seen within a month of consistent use.

The Purina Pro Plan Veterinary Supplements Calming Care is an anti-anxiety supplement for dogs, recommended by veterinarians. It's a probiotic-based powder that helps manage anxious behaviors like excessive vocalization, jumping, pacing, and spinning. The supplement is designed to help dogs cope with stressors such as separation, new visitors, loud noises, or changes in routines.

It also supports positive cardiac activity during stress and boosts the immune system, promoting a positive emotional state for dogs of all breeds and life stages. The product comes in a 30-count box and requires daily administration, with full effects potentially taking up to six weeks. While it is generally safe, it is advisable to consult with a veterinarian before use, especially for pregnant or breeding animals.

Some users may find the waiting period for the full effect to be lengthy, and there are specific safety precautions to follow, such as keeping it out of reach of children and other animals.

Rating
9.6
Effectiveness
Duration of Effect

Most important from
2339 reviews

Effectiveness
This supplement works wonders for high-anxiety dogs, making them noticeably calmer and more relaxed.
Duration of Effect
Noticeable improvement in behavior can be seen within a month of consistent use.
#3

Natural Dog Company Calming Chews for Dogs, Stress & Anxiety Relief Supplement with Chamomile, Valerian Root & Melatonin, Natural Soothing Chews for Travel, Thunder, Fireworks & Separation (90 cnt)

Rating
9.5
Ingredients
Effectiveness

Most important from
10417 reviews

Ingredients
The natural ingredients in these chews give peace of mind and effectively help relax our dogs.
Effectiveness
These calming chews truly work, even for picky dogs that usually avoid medicinal-smelling products.

The Natural Dog Company Calming Chews for Dogs are designed to promote relaxation and composure in dogs facing stressful situations like travel or thunderstorms. These chews stand out with their natural ingredients such as Melatonin, Valerian Root, Chamomile, and Ginger Root, which are commonly known for their calming effects. The use of these ingredients suggests the product should be effective in reducing anxiety and supporting a balanced behavior in dogs.

These chews come in a Peanut Butter & Bacon flavor, making them appealing and enjoyable for dogs. This is a big plus for pet owners who struggle to get their pets to take supplements. Additionally, the absence of CBD or THC ensures that the product is safe for regular use without psychoactive effects.

The chews are suitable for medium to large dog breeds, as per the manufacturer's specification, though this might limit their use for smaller breeds. The form as a chew makes it easy to administer, but the right dosage depending on your dog's size and needs may require consultation with a veterinarian to ensure maximum effectiveness and safety. For pet owners looking for a natural approach to managing their dog's anxiety, these calming chews offer a promising solution, as long as they match your dog's specific needs and the dosage is properly managed.

Rating
9.5
Ingredients
Effectiveness

Most important from
10417 reviews

Ingredients
The natural ingredients in these chews give peace of mind and effectively help relax our dogs.
Effectiveness
These calming chews truly work, even for picky dogs that usually avoid medicinal-smelling products.

Buying Guide for the Best Anti Anxiety Supplement For Dogs

Choosing the right anti-anxiety supplement for your dog can significantly improve their quality of life. It's important to understand the various factors that can influence the effectiveness and safety of these supplements. By considering your dog's specific needs, you can make an informed decision that will help them feel more relaxed and comfortable. Here are some key specifications to consider when selecting an anti-anxiety supplement for your dog.
IngredientsThe ingredients in an anti-anxiety supplement are crucial because they determine the supplement's effectiveness and safety. Look for natural ingredients like chamomile, valerian root, and L-theanine, which are known for their calming properties. Avoid supplements with artificial additives or fillers, as these can cause adverse reactions. If your dog has any allergies or sensitivities, make sure to choose a supplement that does not contain those allergens.
FormAnti-anxiety supplements come in various forms, including chews, tablets, liquids, and powders. The form you choose should be based on what is easiest for you to administer and what your dog prefers. Chews and treats are often more palatable and easier to give, especially for picky eaters. Tablets and capsules can be hidden in food, while liquids and powders can be mixed into meals. Consider your dog's preferences and your convenience when selecting the form.
DosageThe dosage of an anti-anxiety supplement is important to ensure it is effective without causing side effects. Dosage recommendations are usually based on your dog's weight. Always follow the manufacturer's guidelines and consult with your veterinarian to determine the appropriate dosage for your dog. Starting with a lower dose and gradually increasing it can help you monitor your dog's response and adjust as needed.
EffectivenessEffectiveness can vary between different supplements and individual dogs. Look for products with positive reviews and testimonials from other pet owners. Clinical studies and veterinarian recommendations can also provide insight into a supplement's effectiveness. Keep in mind that it may take some trial and error to find the right supplement for your dog, so be patient and observe any changes in their behavior.
SafetySafety is paramount when choosing an anti-anxiety supplement for your dog. Ensure the product is made by a reputable manufacturer and has undergone quality control testing. Check for any potential side effects and interactions with other medications your dog may be taking. Consulting with your veterinarian can help you choose a safe and suitable supplement for your dog's specific health needs.
Duration of EffectThe duration of effect refers to how long the supplement will help keep your dog calm. Some supplements provide short-term relief, ideal for specific events like thunderstorms or vet visits, while others offer long-term support for ongoing anxiety issues. Consider your dog's anxiety patterns and choose a supplement that aligns with their needs. For chronic anxiety, a long-term solution may be more appropriate, while situational anxiety may only require short-term use.

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