10 Best Anti Anxiety Supplement For Dogs 2025 in the United States

Zesty Paws Calming Chews for Dogs are designed to help manage everyday stress and hyperactivity in dogs, making them a good option for keeping pets calm during stressful situations like fireworks, storms, or car rides. These chews contain clinically studied ingredients such as Suntheanine (a premium form of L-Theanine) and Ashwagandha, which promote relaxation and calmness. Additionally, they include Valerian Root, Organic Seed Powder, Magnesium Citrate, L-Tryptophan, Organic Ginger Root, and Organic Passionflower, all known for their calming effects.

The chews come in a turkey flavor, which is generally appealing to dogs, and are suitable for all breeds and life stages, making them versatile. One pack contains 90 chews, which is a convenient quantity for regular use. The chews contain melatonin, which can have varying effects on different dogs, so it's best to consult with a vet before prolonged use. The chews are relatively safe but always monitor your dog's reaction when introducing a new supplement.

The duration of the calming effect can vary, but they are generally effective for a few hours, making them suitable for short-term stress relief. These chews are a solid choice for dog owners looking to manage their pet's anxiety in a natural and convenient way.

VETRISCIENCE Veterinary Strength Calm & Confident Chews offer a convenient and well-researched option to help reduce stress in both dogs and cats. These chicken-flavored chews come in a soft, easy-to-administer form that most pets seem to accept without fuss. The formula includes calming ingredients like L-Theanine and Thiamine, which are known to support brain function and promote relaxation without sedating your pet or causing personality changes.

Dosage is simple and tailored by weight, with the possibility to give the supplement up to twice daily during particularly stressful times. This flexibility is helpful for managing varying levels of anxiety in pets. Safety is a strong point, as the product is rawhide-free and suitable for all life stages and breeds. Many pet owners report noticeable calming effects relatively quickly, though individual results can vary.

One downside is that some pets might require consistent use to maintain effects, and the product is not a one-time fix for severe anxiety issues. These chews serve as a solid choice for pet owners looking for a natural, vet-backed stress relief supplement that supports calm behavior without drowsiness.

The Purina Pro Plan Veterinary Supplements Calming Care is an anti-anxiety supplement for dogs, recommended by veterinarians. It's a probiotic-based powder that helps manage anxious behaviors like excessive vocalization, jumping, pacing, and spinning. The supplement is designed to help dogs cope with stressors such as separation, new visitors, loud noises, or changes in routines.

It also supports positive cardiac activity during stress and boosts the immune system, promoting a positive emotional state for dogs of all breeds and life stages. The product comes in a 30-count box and requires daily administration, with full effects potentially taking up to six weeks. While it is generally safe, it is advisable to consult with a veterinarian before use, especially for pregnant or breeding animals.

Some users may find the waiting period for the full effect to be lengthy, and there are specific safety precautions to follow, such as keeping it out of reach of children and other animals.