10 Best Anti Anxiety Supplement For Dogs 2025 in the United States

Zesty Paws Vet Strength Calming Chews are soft chews designed to help dogs manage everyday stress, nervousness, and separation anxiety. The formula is vet-developed, combining several calming ingredients such as Magnolia Bark Extract, L-Theanine (in the form of Suntheanine), Ashwagandha, Chamomile, Melatonin, Valerian Root, and GABA. These are known to promote relaxation and emotional balance in dogs. The treats come in a smoked turkey flavor, which many dogs find appealing, and are suitable for dogs of all life stages. Dosage is easy to follow and sized by weight, allowing flexible administration from half a chew for smaller dogs to three for larger dogs.

Many users report positive effects during stressful events like vet visits, car rides, or fireworks. However, the effects might vary depending on the dog's sensitivity and specific anxiety triggers. Safety is supported by the vet formulation and natural ingredient choice, but starting with a lower dose is recommended to monitor tolerance. The calming effect tends to last several hours, making it practical for use during known stress periods.

One downside is that while it’s effective for general stress and mild anxiety, it may not fully address severe anxiety or behavioral issues, which might require additional interventions. These chews provide a convenient, tasty option for pet owners seeking a natural, vet-approved calming aid for their dogs.

The Purina Pro Plan Veterinary Supplements Calming Care is an anti-anxiety supplement for dogs, recommended by veterinarians. It's a probiotic-based powder that helps manage anxious behaviors like excessive vocalization, jumping, pacing, and spinning. The supplement is designed to help dogs cope with stressors such as separation, new visitors, loud noises, or changes in routines.

It also supports positive cardiac activity during stress and boosts the immune system, promoting a positive emotional state for dogs of all breeds and life stages. The product comes in a 30-count box and requires daily administration, with full effects potentially taking up to six weeks. While it is generally safe, it is advisable to consult with a veterinarian before use, especially for pregnant or breeding animals.

Some users may find the waiting period for the full effect to be lengthy, and there are specific safety precautions to follow, such as keeping it out of reach of children and other animals.

The Natural Hemp Calming Chews for Dogs by Pet Honesty are designed to help dogs manage occasional anxiety and stress related to travel, vet visits, separation, or loud noises like thunder. These chews come in a tasty chicken flavor and are easy to give since they are soft chews. Their ingredients, such as Valerian Root, Chamomile, L-Theanine, Ashwagandha, and Magnesium Citrate, work together to promote calmness and reduce anxious behavior. According to user feedback, about 80% of dog owners observed improvements within a month, suggesting the supplement can be effective for many dogs.

Dosage is straightforward, based on your dog’s weight, and can be split between morning and evening, making it flexible to use. The product emphasizes safety by avoiding artificial fillers, preservatives, and flavors, which is a plus for pet owners concerned about natural ingredients. The calming effects tend to build over time, so it may not provide immediate relief in very stressful moments. Individual dogs may respond differently, so some trial might be needed to see how well it works for your pet.

This supplement is suitable for all dog breeds and adults, making it a versatile option for pet parents looking for a natural way to support their dog's mental well-being. For dogs that struggle with occasional nervousness or stress, these chews offer a gentle alternative to prescription medications with added benefits from well-known calming herbs and nutrients. Consistent use as directed is important to notice results.