10 Best Arthritis Creams 2026 in the United States

Biofreeze Professional Gel is a popular choice for those seeking relief from arthritis pain, muscle soreness, and joint discomfort. The active ingredient, menthol, is known for its cooling effect and fast-acting relief, which is particularly beneficial for managing arthritis pain. The gel form and the 32 fl oz bottle with a pump make it convenient for application on both small and large areas, such as knees and the lower back. This product is also well-regarded by professionals, including pharmacists, physical therapists, and chiropractors, adding credibility to its effectiveness.

Additionally, it's HSA/FSA eligible, potentially allowing users to save on costs. On the plus side, the gel is colorless, which means it won't stain clothing, and it’s made without NSAIDs, reducing the risk of certain side effects. However, some users may find the menthol scent to be strong, which could be a drawback for those sensitive to strong smells. The gel's absorption rate is typically fast, but people with sensitive skin should test a small area first to ensure there’s no irritation. The duration of relief varies, but many users report long-lasting effects.

It's also worth noting that the product has not been tested on animals, which is a significant plus for ethically-conscious consumers. This product is best suited for individuals seeking targeted, effective, and fast-acting pain relief for arthritis and muscle soreness.

Biofreeze Cream is a menthol-based topical pain reliever widely recommended by healthcare professionals for muscle and joint pain, including arthritis-related discomfort. Its main active ingredient, menthol, provides a cooling sensation that helps reduce minor aches from arthritis, strains, bruises, and back or neck pain. The cream is non-greasy and absorbs quickly, which makes it convenient for daily use without leaving a heavy residue. It also contains natural moisturizers, helping to avoid dry or irritated skin—a common concern with frequent topical applications.

The scent is typical of menthol products: refreshing but noticeable, which some users appreciate for the cooling effect, while others might find it a bit strong. Biofreeze is free of common pain relief drugs like NSAIDs, aspirin, or ibuprofen, making it suitable for people who want to avoid those ingredients or have sensitivities. Relief lasts for a few hours, offering targeted pain control, though it typically requires reapplication for ongoing issues. The cream’s 3-ounce jar is TSA-friendly and portable, ideal for those who need on-the-go pain management.

It is effective for mild to moderate arthritis pain and related muscle soreness, but it does not offer deep or long-lasting relief for severe cases. Some users may also find the cooling effect too intense initially. Biofreeze Cream is a solid choice for arthritis sufferers looking for quick, easy-to-apply cooling relief without medication, especially if you prefer a product trusted by healthcare professionals and free from harsh chemicals.

Sub Zero Cooling Pain Relief Gel is designed to provide fast, cooling relief for muscle, joint, and nerve pain, including arthritis discomfort. It uses menthol as a primary active ingredient, which offers a cooling sensation that helps numb pain quickly. The gel also includes cat's claw herb and other natural extracts to support long-lasting relief. It is colorless and non-greasy, making it comfortable to apply without leaving a residue. The gel absorbs quickly into the skin, which is good for those wanting prompt pain relief without waiting.

It comes in a large 1-gallon bottle with a pump, ideal for regular use at home but less convenient for travel or small doses. The scent is mild due to menthol, which some users may find refreshing, though people sensitive to strong fragrances might want to test it first. While the gel is generally suitable for most skin types, those with very sensitive skin should be cautious and try a small amount initially to check for irritation. The relief provided is fast-acting and can last for a reasonable time, making it useful after exercise, physical work, or arthritis flare-ups.

This product is best suited for people who need frequent, repeated application at home rather than on-the-go use, given its size. Sub Zero Cooling Pain Relief Gel is a solid choice for anyone dealing with muscle or joint pain looking for quick cooling relief with natural ingredients; however, it may not be the best option if you require something portable or fragrance-free.