10 Best Bed Bug Killers 2025 in the United States

The Ortho Home Defense Max Bed Bug Killer is a spray designed to quickly kill bed bugs, including those resistant to common pesticides, and their eggs. It also works against fleas, brown dog ticks, and several other pests, making it versatile for home use. One of its strong points is the residual effect, lasting up to 16 weeks on non-porous surfaces like ceramic, which helps keep bed bugs away for an extended period after application.

This spray is best used as a spot treatment around bed frames, headboards, floors, and carpets where bed bugs are most likely to hide. It comes in an 18-ounce bottle and is unscented, which is beneficial for those who prefer to avoid strong chemical smells. The product is relatively easy to use, requiring just spraying in targeted areas rather than large-scale application. Users should still follow instructions carefully to avoid overexposure, especially around children and pets.

Many users rate it highly for effectiveness, with over 30,000 reviews and a solid average rating of 4.4 out of 5 stars. For severe infestations, it is often recommended to combine this spray with other products like the Ortho Home Defense Max Bed Bug trap and powder (sold separately) for best results. This product suits homeowners looking for a focused, relatively simple treatment to manage and prevent bed bug problems, especially when used as part of a broader control strategy.

Ortho Home Defense Max Bed Bug, Flea, and Tick Killer with Comfort Wand is a liquid spray that targets bed bugs, bed bug eggs, fleas, and ticks. The product is designed to kill even pyrethroid-resistant bed bugs, making it effective against tough infestations. It's suitable for indoor use, particularly as a spot treatment around areas like bed frames, baseboards, and mattress seams.

The Comfort Wand included with the spray allows for precise application to hard-to-reach places, enhancing ease of use and targeting efficiency. The 1-gallon container ensures ample supply for larger spaces or repeated treatments, and the spray form is convenient for quick application.

Users should consider safety precautions when using this chemical-based product, especially around children and pets. Additionally, because it's part of the Ortho Bed Bug Solution System, optimal results are achieved when used alongside Step 1: Detect and Trap and Step 3: Cracks and Crevices products. While highly effective, the residual effect might require follow-up treatments to ensure complete eradication. The product’s weight and dimensions make it somewhat bulky, which might be inconvenient for some users.

The MGK Crossfire® Bed Bug Concentrate is a professional-grade bed bug killer designed to combat pyrethroid-resistant bed bug strains. It features a patented formula with two active ingredients, Clothianidin and Metofluthrin, along with Piperonyl Butoxide as a synergist, making it highly effective in killing bed bugs at all life stages, including eggs.

One of its standout strengths is that it begins working within minutes of exposure, providing quick knockdown and kill. Additionally, it is non-staining, making it suitable for direct application on mattresses and other indoor areas without causing damage to fabrics or surfaces. The concentrate's ease of use is notable, as a 13-ounce bottle can be mixed to create one gallon of finished product, simplifying the preparation and application process for users.

MGK, the manufacturer, has a long-standing reputation in the pest control industry, adding a layer of trust and reliability to the product. As with any chemical treatment, safety precautions must be observed to prevent harm to humans and pets. MGK Crossfire® Bed Bug Concentrate is a potent and efficient solution for severe bed bug infestations, particularly those involving pyrethroid-resistant strains, and is recommended for residential, institutional, and commercial use.