10 Best Bed Bug Spray For Mattress 2025 in the United States

The Ortho Home Defense Max Bed Bug Killer spray is designed to tackle tough bed bugs, including those resistant to common treatments, as well as their eggs. It also works against fleas, brown dog ticks, and other household pests, making it a versatile choice for pest control around your mattress and bedroom. One of its key benefits is a long-lasting effect—it can keep killing bugs for up to 16 weeks on hard, non-porous surfaces, which helps reduce the need for frequent reapplications. The spray is unscented, so it won’t leave a strong chemical smell that can be unpleasant in bedrooms.

This spray is intended for spot treatment, meaning you apply it around bed frames, headboards, floors, and carpets where bed bugs hide, rather than soaking your mattress directly. This makes it safer for mattress materials but requires careful application to avoid damage. The product is easy to use with a convenient spray bottle and is highly rated by many users for effectiveness. It is important to note that the residual effect is most reliable on non-porous surfaces like wood or tile, so effectiveness might be less on fabric mattresses or soft surfaces.

For best results, it is recommended to use this spray alongside other products in the Ortho Home Defense Max system, like traps and powders, to catch and eliminate all bed bug life stages. If you want a convenient, strong spray that handles resistant bed bugs and keeps working for months with minimal odor, this product represents a solid option—especially when combined with additional bed bug control methods.

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is designed to tackle bed bugs, including pyrethroid-resistant types, as well as their eggs, fleas, and ticks. A notable feature is its Comfort Wand, which makes applying the spray easier, especially in tight and hard-to-reach spots such as mattress seams and folds.

This product is part of a comprehensive system that includes detection and trapping, which suggests it works best in conjunction with other products for maximum effectiveness. The active ingredients are potent against all life stages of bed bugs, making it highly effective in eradication. It's also designed for indoor use around bed frames and baseboards, suggesting it's safe for mattresses when used correctly.

The residual effect isn't clearly stated, so it might require repeated applications. The product has a 'tick' scent, which might not be pleasant for everyone. Weighing 9.39 pounds and coming in a 1-gallon size, it's a sizable product, making it suitable for treating larger areas. This spray is ideal for individuals looking for a reliable solution to bed bug infestations and willing to follow a complete treatment system for optimal results.

The Hot Shot Ready-to-Use Bed Bug Killer Spray is designed to effectively tackle bed bugs and their eggs as well as fleas and dust mites. Its active ingredients enable it to kill bed bugs at all life stages, including larvae and eggs, making it a comprehensive solution. The water-based formula is non-staining and leaves no odor, which is a significant advantage for use on mattresses and other indoor areas.

This spray is safe for mattresses but should not be used on pets, ensuring targeted application without harming household items. It's easy to use; simply spray the areas until damp, but avoid saturation, and repeat every two weeks while bed bugs are present. Although the product requires regular application as part of a cycle, it helps achieve effective control over bed bugs. However, the need for frequent reapplication might be considered a drawback for some users.

The spray comes in a large 1-gallon container, making it suitable for extensive treatments. While its weight and size might be cumbersome for some, the ease of use and effectiveness make it a strong choice for those dealing with bed bugs on their mattresses.