10 Best Bed Bug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is a versatile 1-gallon spray designed to tackle bed bugs, including their eggs, as well as fleas and ticks. One of its strong points is its effectiveness against even the toughest bed bugs, including those resistant to common treatments. The Comfort Wand that comes with it makes it easier to apply, especially in hard-to-reach places such as mattress seams and baseboards. This feature can be a significant advantage for those dealing with infestations in multiple areas of their home.

Safety-wise, it should be used with care, keeping in mind the advice to use it as a spot treatment. It’s also important to note that while it is effective, it forms only one part of a three-step treatment system recommended by Ortho, which may require additional purchases for the best results. Users have generally rated it positively, with a 4.4 out of 5-star rating from nearly 29,000 reviews, indicating a high level of customer satisfaction. However, some users might find the scent unpleasant as it is noted to have a tick scent.

In terms of convenience, the product’s large volume (1 gallon) means you’ll have plenty of spray to cover a significant area, but it also makes the container heavier and potentially more cumbersome to handle. This product is well-suited for those looking for a comprehensive, albeit multi-step, solution to bed bug and flea infestations in their home.

The Bed Bug Killer 16 oz EcoVenger by EcoRaider is a natural, plant-extract-based spray that promises 100% efficacy in killing bed bugs at all stages, including eggs and pesticide-resistant bugs. It is USDA Bio-Certified, non-toxic, and safe for use around children and pets, making it a strong choice for households with sensitive environments. This spray has been tested in public housing buildings, showing its reliability in real-world conditions. Additionally, it offers extended residual protection, lasting for up to two weeks after application.

The primary ingredients include geraniol and cedarwood oil, which give it a natural scent that may be more pleasant than chemical alternatives. However, the cedarwood scent might still be strong for some users. Ease of use is also highlighted as it can be sprayed directly on mattresses and box springs. This product's emphasis on safety and eco-friendliness adds to its appeal, though the need to use it within six months after opening could be inconvenient for some. On the upside, the introduction of a batch ID for tracking ensures quality control.

EcoVenger's Bed Bug Killer is highly effective and safe, but its scent and shelf life after opening could be potential drawbacks for some users.

The BASF PT Alpine Flea & Bed Bug Killer is a ready-to-use aerosol spray designed for swift and effective pest control. It claims to offer quick results with a fast knockdown of bed bugs and fleas, making it a practical choice for those needing immediate relief. The spray is designed to be effective for up to three weeks, and it even targets hatching eggs for up to seven months, ensuring long-lasting control. This makes it an excellent option for maintaining an ongoing defense against infestations.

While it provides extensive coverage, it should not be applied to the entire mattress, only specific areas like edges, tufts, folds, sides, and seams, which might require some careful application to ensure thorough treatment. The active ingredient Dinotefuran is safe for public health use and in food handling environments, adding a layer of safety, but like all insecticides, it’s crucial to follow the label instructions meticulously. The quick-dry, non-staining formula ensures it won’t damage surfaces, which is a significant advantage for household use.

Users have rated it highly for being easy to apply and effective, although handling the aerosol can might be slightly challenging for some. Its versatility makes it suitable for various environments, including homes, hotels, and veterinary clinics. In terms of odor, most users report minimal to no lingering scent, which enhances user comfort. This spray ranks well in customer reviews and sales, indicating general satisfaction and reliability. However, state restrictions may apply, which could limit availability in certain areas.