10 Best Bed Bug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug Killer is a spray designed to target tough bed bugs, including those resistant to common chemicals, and their eggs. It comes in an 18-ounce bottle and is sold in a convenient two-pack. This spray works well as a spot treatment around bed frames, headboards, floors, and carpets. One of its strong points is that it continues to kill bed bugs for up to 16 weeks on non-porous surfaces like ceramic, which helps maintain protection over time. Besides bed bugs, it also kills fleas, brown dog ticks, and other pests, making it a versatile option.

The spray is unscented, which is a plus if you prefer to avoid strong or unpleasant odors often found in pest control products. In terms of safety, while the product is effective, it is meant for targeted spots rather than widespread application, so careful use according to instructions is important. The spray is easy to apply and fits well for those who want a straightforward solution without complicated steps.

This product works best as part of a treatment plan, since it’s primarily for spot treatment and is recommended to be used alongside other products like traps and powders from the same range to fully eliminate bed bugs. If you’re looking for a spray that handles resistant bugs effectively, offers residual protection, and doesn’t have a strong smell, this is a solid choice. It is not an all-in-one solution and performs best when combined with other measures.

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is a versatile 1-gallon spray designed to tackle bed bugs, including their eggs, as well as fleas and ticks. One of its strong points is its effectiveness against even the toughest bed bugs, including those resistant to common treatments. The Comfort Wand that comes with it makes it easier to apply, especially in hard-to-reach places such as mattress seams and baseboards. This feature can be a significant advantage for those dealing with infestations in multiple areas of their home.

Safety-wise, it should be used with care, keeping in mind the advice to use it as a spot treatment. It’s also important to note that while it is effective, it forms only one part of a three-step treatment system recommended by Ortho, which may require additional purchases for the best results. Users have generally rated it positively, with a 4.4 out of 5-star rating from nearly 29,000 reviews, indicating a high level of customer satisfaction. However, some users might find the scent unpleasant as it is noted to have a tick scent.

In terms of convenience, the product’s large volume (1 gallon) means you’ll have plenty of spray to cover a significant area, but it also makes the container heavier and potentially more cumbersome to handle. This product is well-suited for those looking for a comprehensive, albeit multi-step, solution to bed bug and flea infestations in their home.

The Hygea Natural Extra Strength Bed Bug & Mite Natural Travel Spray is designed for on-the-go protection against bed bugs and mites. One of its main strengths is its effectiveness; it’s originally formulated for pest control professionals and claims to kill bugs on contact. This makes it highly effective for immediate relief from infestations. Additionally, it’s child and pet-friendly, meaning it’s safe to use around your family and pets, which is a crucial consideration for many users.

The travel-size 3oz bottle is TSA approved, making it convenient for travel purposes like hotels and backpacks, which can often be hotbeds for bedbugs. The spray is odorless and stain-free, ensuring it won’t leave any unsightly marks or unpleasant smells on surfaces such as mattresses, clothing, or upholstery. This is particularly useful for individuals who are sensitive to strong odors or don't want to damage their belongings. The product also comes with a step-by-step guide for effective use, helping users get the best results from their purchase.

On the downside, the small 3oz bottle may not be sufficient for larger infestations or extensive use, requiring multiple purchases. Also, while it’s odorless and stain-free, users might need to follow the guide precisely to ensure complete eradication of pests, which might be a bit inconvenient for some. In summary, the Hygea Natural Extra Strength Bed Bug & Mite Natural Travel Spray is a potent, safe, and convenient option for those needing a quick and effective solution against bed bugs and mites, especially while traveling.