10 Best Bed Bug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is a versatile 1-gallon spray designed to tackle bed bugs, including their eggs, as well as fleas and ticks. One of its strong points is its effectiveness against even the toughest bed bugs, including those resistant to common treatments. The Comfort Wand that comes with it makes it easier to apply, especially in hard-to-reach places such as mattress seams and baseboards. This feature can be a significant advantage for those dealing with infestations in multiple areas of their home.

Safety-wise, it should be used with care, keeping in mind the advice to use it as a spot treatment. It’s also important to note that while it is effective, it forms only one part of a three-step treatment system recommended by Ortho, which may require additional purchases for the best results. Users have generally rated it positively, with a 4.4 out of 5-star rating from nearly 29,000 reviews, indicating a high level of customer satisfaction. However, some users might find the scent unpleasant as it is noted to have a tick scent.

In terms of convenience, the product’s large volume (1 gallon) means you’ll have plenty of spray to cover a significant area, but it also makes the container heavier and potentially more cumbersome to handle. This product is well-suited for those looking for a comprehensive, albeit multi-step, solution to bed bug and flea infestations in their home.

The Bed Bug Killer 16 oz EcoVenger by EcoRaider is a natural, plant-extract-based spray that promises 100% efficacy in killing bed bugs at all stages, including eggs and pesticide-resistant bugs. It is USDA Bio-Certified, non-toxic, and safe for use around children and pets, making it a strong choice for households with sensitive environments. This spray has been tested in public housing buildings, showing its reliability in real-world conditions. Additionally, it offers extended residual protection, lasting for up to two weeks after application.

The primary ingredients include geraniol and cedarwood oil, which give it a natural scent that may be more pleasant than chemical alternatives. However, the cedarwood scent might still be strong for some users. Ease of use is also highlighted as it can be sprayed directly on mattresses and box springs. This product's emphasis on safety and eco-friendliness adds to its appeal, though the need to use it within six months after opening could be inconvenient for some. On the upside, the introduction of a batch ID for tracking ensures quality control.

EcoVenger's Bed Bug Killer is highly effective and safe, but its scent and shelf life after opening could be potential drawbacks for some users.

The Hot Shot Ready-to-Use Bed Bug Killer Spray is a versatile option designed to tackle bed bugs, bed bug eggs, fleas, and dust mites. Its water-based formula is beneficial as it is non-staining and leaves no odor, making it more pleasant for indoor use without worrying about lingering smells or marks. This spray is easy to use for spot treatments on mattresses, ensuring that all crucial areas are covered without the need for extensive spraying, although it should not be used on pets.

The 32-ounce volume provides ample product for multiple applications, which is necessary since the instructions recommend reapplication every two weeks as part of a comprehensive treatment plan. Users need to be diligent with this reapplication schedule to maintain control over an infestation, which could be seen as a drawback for those looking for a one-time solution.

Despite this, its targeted spray form and odorless nature make it a user-friendly option for those dealing with bed bugs and related pests inside the home. It is particularly effective when used as part of a broader pest control strategy.