10 Best Calming Pills For Dogs 2025 in the United States

Pet Honesty Natural Hemp Calming Chews for Dogs offer a natural solution to canine anxiety and stress. The inclusion of ingredients like valerian root, chamomile, magnesium, and organic hemp makes these chews a holistic option for dogs experiencing nervousness, hyperactivity, or stress from environmental changes. The product is easy to administer, with dosage varying based on the dog's weight, making it accessible for dogs of different sizes.

These chews come in an appealing beef liver flavor, which should encourage most dogs to take them willingly. Since they are free from soy, wheat, corn, and artificial preservatives, they are a healthier option for dogs with dietary restrictions or sensitivities. Additionally, being made in the USA in a GMP-compliant facility ensures high safety and quality standards, and the NASC membership adds an extra layer of trustworthiness.

The chews may not work for all dogs, and effectiveness can vary based on individual canine needs and conditions. Some users might notice only mild improvements, and the duration of effect might not be as long-lasting as desired. While side effects are generally minimal due to the natural ingredients, it’s always advisable to start with a lower dosage to gauge the dog’s reaction.

The Vetoquinol Zylkene Calming Support Supplement is designed to help large dogs (33-132lbs) cope with anxiety and stress from external factors like travel, loud noises, and changes in routine. The key ingredient, Alpha-Casozephine, is a naturally occurring milk protein that promotes relaxation without causing drowsiness, making it suitable for daily use. Its lactose-free formula is gentle on sensitive stomachs, which is a significant advantage for dogs with dietary sensitivities.

Each capsule contains 450mg of the calming compound, and it can be easily administered by opening the capsule and mixing it with the dog's food. This makes it a convenient option for pet owners who may struggle with giving their pets pills directly. As it is a natural supplement, it may take some time before the calming effects become apparent. It is important to monitor your dog for any adverse reactions, although side effects appear to be rare.

Vetoquinol Zylkene is veterinarian-recommended, which adds a layer of trust and credibility to the product. This supplement could be a valuable tool for managing your dog's anxiety, especially during stressful situations, but results may vary.

The VetriScience Calm & Confident Chews are soft treats designed to help reduce stress and anxiety in both dogs and cats. They come in an easy-to-give chicken-flavored chew form, which most pets find appealing. The formula includes calming ingredients like L-Theanine and Thiamine, which support a relaxed mood and brain function without making pets sleepy or changing their personality. This supplement is suitable for all life stages and breed sizes, with clear dosage instructions based on your pet’s weight. You can give it once or twice daily, or more during stressful events, making it flexible for different situations.

One of the strengths of these chews is that they avoid rawhide, which some pets may have trouble digesting or be allergic to. Many pet owners report noticeable calming effects, especially in situations like vet visits or thunderstorms.

If you want a vet-formulated, science-backed calming aid that’s easy to dose and palatable for your dog or cat, this product is a solid option. It works best for pets with mild to moderate stress and owners looking for a natural supplement without sedation. For pets with severe anxiety or those needing long-lasting effects, you might want to consult a vet for additional solutions.