10 Best Calming Pills For Dogs 2025 in the United States

Pet Honesty Natural Hemp Calming Chews for Dogs offer a natural solution to canine anxiety and stress. The inclusion of ingredients like valerian root, chamomile, magnesium, and organic hemp makes these chews a holistic option for dogs experiencing nervousness, hyperactivity, or stress from environmental changes. The product is easy to administer, with dosage varying based on the dog's weight, making it accessible for dogs of different sizes.

These chews come in an appealing beef liver flavor, which should encourage most dogs to take them willingly. Since they are free from soy, wheat, corn, and artificial preservatives, they are a healthier option for dogs with dietary restrictions or sensitivities. Additionally, being made in the USA in a GMP-compliant facility ensures high safety and quality standards, and the NASC membership adds an extra layer of trustworthiness.

The chews may not work for all dogs, and effectiveness can vary based on individual canine needs and conditions. Some users might notice only mild improvements, and the duration of effect might not be as long-lasting as desired. While side effects are generally minimal due to the natural ingredients, it’s always advisable to start with a lower dosage to gauge the dog’s reaction.

Purina Pro Plan Veterinary Supplements Calming Care is a powder supplement designed to help dogs manage anxiety and stress-related behaviors like excessive barking, pacing, or restlessness. Its main active ingredient is the probiotic Bifidobacterium longum BL999, which supports calm behavior by promoting a positive emotional state and healthy immune function. The product is suitable for all dog breeds and life stages, making it a versatile option for pet owners. Dosage is simple to follow—one packet daily—and it may take up to six weeks for full effectiveness. The powder form allows easy mixing with food, making administration convenient for most dogs.

Some users report good results in reducing anxiety, supported by positive reviews and endorsement as a veterinarian-recommended probiotic brand. Because effects build gradually, it may not provide quick relief for acute stress situations. Side effects appear minimal, but if symptoms worsen or don’t improve, consultation with a veterinarian is advised. This product is ideal for dog owners seeking a natural, gentle aid for ongoing anxiety management rather than immediate calming in emergencies.

The Vetoquinol Zylkene Calming Support Supplement is designed to help large dogs (33-132lbs) cope with anxiety and stress from external factors like travel, loud noises, and changes in routine. The key ingredient, Alpha-Casozephine, is a naturally occurring milk protein that promotes relaxation without causing drowsiness, making it suitable for daily use. Its lactose-free formula is gentle on sensitive stomachs, which is a significant advantage for dogs with dietary sensitivities.

Each capsule contains 450mg of the calming compound, and it can be easily administered by opening the capsule and mixing it with the dog's food. This makes it a convenient option for pet owners who may struggle with giving their pets pills directly. As it is a natural supplement, it may take some time before the calming effects become apparent. It is important to monitor your dog for any adverse reactions, although side effects appear to be rare.

Vetoquinol Zylkene is veterinarian-recommended, which adds a layer of trust and credibility to the product. This supplement could be a valuable tool for managing your dog's anxiety, especially during stressful situations, but results may vary.