10 Best Calming Products For Cats 2025 in the United States

The Vetoquinol Zylkene Calming Supplement is designed to help small dogs and cats manage stress from situations like travel, vet visits, or loud noises. Its main calming ingredient, alpha-casozepine, comes from a milk protein, making it a natural option that avoids drowsiness or harsh side effects commonly seen in other calming products.

This supplement is lactose-free and gentle on sensitive stomachs, which is beneficial for cats with digestive sensitivities. The package contains capsules that you open and sprinkle over your pet’s food, making it straightforward to use daily. This daily routine can support behavioral issues and help your cat stay calm during stressful events.

With a solid positive rating from many users, Zylkene offers a safe, gentle, and easy-to-administer way to support your cat’s relaxation. Pet owners should monitor their cat’s response and ensure proper dosing.

Pet Honesty Calming Chews for Cats are designed as tasty, easy-to-give treats that help reduce anxiety and promote relaxation in cats, especially during stressful events like travel, vet visits, or separation. They feature natural calming ingredients such as L-Theanine, L-Tryptophan, Chamomile, and Thiamine (Vitamin B1), which support the nervous system and help soothe anxious behavior. The chews come in a crunchy and creamy chicken flavor that many cats find appealing, making administration less challenging.

These chews are intended for all ages and medium breeds, with dosage based on the cat's weight, and can be given daily to maintain a calming effect over time. The product is made in the USA under strict safety standards, free from common allergens like corn, wheat, and soy, and contains no artificial additives, which supports its safety profile. The duration of the calming effect can vary between cats, and some cats might not respond to supplements as expected.

The product is well-rated by many users, although individual preferences for taste and texture may differ, so it might require some trial and error. This makes these chews a natural, convenient option for cat owners seeking to ease their pet’s stress with minimal fuss, especially if their cat enjoys flavored treats and needs support in mildly stressful situations.

The FELIWAY Optimum diffuser uses synthetic pheromones designed to mimic natural calming signals cats give each other, making it a drug-free and non-sedating option. This makes it a good fit for cat owners looking for a safe, gentle way to reduce stress-related behaviors like spraying, scratching, and fearfulness. It works continuously for up to 30 days per vial, covering about 700 square feet, which suits most home environments with one or two diffusers. It’s simple to use—just plug into an outlet with some open space around it for best effect—and designed specifically for cats, so it won’t affect people or other pets. Users report significant reductions in common stress behaviors, which supports its effectiveness.

Because it relies on pheromones, results can vary from cat to cat depending on individual preferences and sensitivity. The diffuser must be replaced every six months and only with official FELIWAY refills, which adds some ongoing cost and limits flexibility with third-party products. Placement matters, too; it shouldn’t be hidden behind furniture or near litter boxes to work well.

While some cats respond quickly, others might take longer or need additional calming support. FELIWAY Optimum is a trusted, veterinarian-recommended calming product best suited for cat owners who want a safe, easy-to-use, and steady way to ease their cat’s stress without medication, though it requires monthly maintenance and careful placement for best results.