10 Best Cold Sore Creams 2025 in the United States

Abreva 10 Percent Docosanol Cold Sore Treatment is a popular choice for those dealing with fever blisters, effectively helping to shorten the healing time. Containing 10 percent docosanol, it's clinically proven to address the symptoms associated with cold sores, such as tingling, pain, burning, and itching, and can help heal them in as little as 2.5 days. This makes it a strong contender in the cold sore cream category, especially for people seeking quick relief and recovery.

The product comes in two 0.07 oz tubes, which are portable and easy to carry around. This convenience makes it suitable for individuals who may experience sudden outbreaks and need treatment on the go. Being the number one dermatologist-recommended cold sore treatment also adds to its credibility, making users feel more confident in its effectiveness.

Abreva cold sore cream is well-suited for individuals looking for an effective, fast-acting solution to cold sores, particularly for those who appreciate convenience and dermatologist backing. Potential users should be mindful of the need for regular application to achieve the best outcomes.

The Mederma Fever Blister Discreet Healing Patch is designed to offer an effective solution for those dealing with cold sores. One of its standout features is its ability to instantly conceal cold sores, allowing users to feel more confident in social situations. The patches utilize hydrocolloid gel technology, which not only hides the sore but also creates an environment conducive to faster healing. Each patch can provide protection for up to 12 hours, helping to safeguard the sore from further contamination and irritation, which is particularly beneficial during the early stages of a cold sore outbreak.

In terms of ease of use, these patches come with a no-touch applicator, making it simple to apply them accurately without the risk of spreading the virus. They are also designed to stay in place, providing both protection and concealment.

The Mederma Fever Blister Discreet Healing Patch is a solid choice for anyone looking to manage the appearance of cold sores while promoting healing. It particularly benefits those who prioritize discretion and ease of use in their treatment options.

Burt's Bees Cold Sore Treatment and Medicated Lip Balm is a solid choice for anyone suffering from cold sores. It combines effective ingredients like menthol, eucalyptus oil, and natural moisturizing oils like jojoba and meadowfoam, which can help soothe pain and promote healing. The inclusion of rhubarb and sage adds a natural touch, which is a bonus for those looking for clean skincare options. The product is easy to apply and recommended for use up to 3-4 times daily, making it quite user-friendly.

One of the strengths of this product is its natural formulation, free from parabens and synthetic additives, which might appeal to individuals who prefer organic or natural skincare. The combination of the cold sore treatment and the medicated lip balm in one package is also convenient, as it ensures that users can alleviate symptoms while keeping their lips hydrated.

There are some potential drawbacks to consider. While the natural ingredients are great for many, some users may find that the relief isn’t as fast-acting as they would prefer, especially if they require immediate pain relief. Additionally, the 0.07 oz. cold sore treatment tube is relatively small, which might not last long for frequent applications if the cold sore is particularly stubborn. The product is designed for dry skin, which could limit its effectiveness for those with different skin types. Lastly, while it’s accessible to carry, some may find the tubes slightly cumbersome compared to more traditional cold sore treatments that come in stick forms.