10 Best Cold Sore Creams 2025 in the United States

Abreva 10 Percent Docosanol Cold Sore Treatment is a popular choice for those dealing with fever blisters, effectively helping to shorten the healing time. Containing 10 percent docosanol, it's clinically proven to address the symptoms associated with cold sores, such as tingling, pain, burning, and itching, and can help heal them in as little as 2.5 days. This makes it a strong contender in the cold sore cream category, especially for people seeking quick relief and recovery.

The product comes in two 0.07 oz tubes, which are portable and easy to carry around. This convenience makes it suitable for individuals who may experience sudden outbreaks and need treatment on the go. Being the number one dermatologist-recommended cold sore treatment also adds to its credibility, making users feel more confident in its effectiveness.

Abreva cold sore cream is well-suited for individuals looking for an effective, fast-acting solution to cold sores, particularly for those who appreciate convenience and dermatologist backing. Potential users should be mindful of the need for regular application to achieve the best outcomes.

The Quantum Health Lip Clear Lysine+ Cold Sore Treatment brings several strengths to the table. It promises to cut the healing time for cold sores by up to 50% due to its active ingredient, L-Lysine, which is backed by scientific research. The formulation includes Menthol and 14 herbal ingredients, providing fast-acting pain and itch relief as well as deep moisturization. This is beneficial for those looking for immediate comfort and nourishment for their lips. The balm is transparent and can be discreetly worn under other lip products, adding to its convenience for everyday use without visible residue.

Additionally, it is formulated with Calendula, Vitamin E, and Propolis, which contribute to lip health through their soothing and moisturizing properties. However, it's important to note that this product is relatively small, with each pack containing just 0.25 oz of ointment. For some users, the size might necessitate frequent repurchasing, especially during severe or recurrent outbreaks. Additionally, while the product is rich in natural ingredients, it may not work equally well for everyone, and individual results may vary.

This cold sore treatment is a strong contender for those needing quick relief and effective healing, provided the small size is suitable for their needs.

Burt's Bees Cold Sore Treatment and Medicated Lip Balm is a solid choice for anyone suffering from cold sores. It combines effective ingredients like menthol, eucalyptus oil, and natural moisturizing oils like jojoba and meadowfoam, which can help soothe pain and promote healing. The inclusion of rhubarb and sage adds a natural touch, which is a bonus for those looking for clean skincare options. The product is easy to apply and recommended for use up to 3-4 times daily, making it quite user-friendly.

One of the strengths of this product is its natural formulation, free from parabens and synthetic additives, which might appeal to individuals who prefer organic or natural skincare. The combination of the cold sore treatment and the medicated lip balm in one package is also convenient, as it ensures that users can alleviate symptoms while keeping their lips hydrated.

There are some potential drawbacks to consider. While the natural ingredients are great for many, some users may find that the relief isn’t as fast-acting as they would prefer, especially if they require immediate pain relief. Additionally, the 0.07 oz. cold sore treatment tube is relatively small, which might not last long for frequent applications if the cold sore is particularly stubborn. The product is designed for dry skin, which could limit its effectiveness for those with different skin types. Lastly, while it’s accessible to carry, some may find the tubes slightly cumbersome compared to more traditional cold sore treatments that come in stick forms.