10 Best Cough Suppressants 2025 in the United States

Mucinex DM Max Liquid Cough & Cold Medicine contains two key active ingredients: guaifenesin (400mg) and dextromethorphan (20mg). Guaifenesin is an expectorant that helps to thin and loosen mucus, making it easier to cough up, while dextromethorphan acts as a cough suppressant to provide relief from persistent coughing.

The formulation is in a liquid form, making it easier for adults to swallow, particularly those who have difficulty with pills. The extended-release feature ensures that the effects last up to 4 hours, providing a reasonable duration of relief between doses. One common side effect of guaifenesin is gastrointestinal discomfort, although it is generally well-tolerated. Dextromethorphan can sometimes cause dizziness or drowsiness, so caution is advised.

This product is a combination of expectorant and cough suppressant, which can be highly beneficial for those needing multi-symptom relief from both mucus congestion and coughing. It is particularly well-suited for adults dealing with cold and flu symptoms who require an effective and trusted brand. Mucinex is widely recommended by doctors and pharmacists, adding to its credibility. On the downside, the 4-hour relief might require multiple doses throughout the day, which could be inconvenient for some users. Additionally, it is always advisable to consult with a healthcare provider before use, especially for those with pre-existing health conditions or those taking other medications.

The Delsym 12 Hour Cough and Nighttime Fast Relief combo pack offers two different cough medicines designed to tackle coughs throughout the day and night. The 12 Hour Cough Liquid contains Dextromethorphan Polistirex, which is an effective cough suppressant that works for up to 12 hours. This means fewer doses and longer relief during the day. It is alcohol-free and comes in a pleasant orange flavor, which may be easier to take for many people.

The Nighttime Fast Relief liquid combines three active ingredients: Dextromethorphan HBr to suppress coughing, Acetaminophen to reduce fever and pain, and Triprolidine, an antihistamine that helps with runny nose and sneezing. This combination aims to help you sleep better by addressing several nighttime symptoms at once. Because it contains multiple ingredients, you should be cautious if you are sensitive to any of them or are taking other medications with acetaminophen or antihistamines. Some users might experience typical side effects like drowsiness from the nighttime formula.

Delsym is the #1 pharmacist-recommended OTC cough suppressant brand, which suggests reliability and trust. If you only need simple cough relief without additional symptom treatment, the nighttime formula might be more than necessary. This combo pack is suited for those looking for all-day cough control plus multi-symptom relief at night, making it a convenient option for managing persistent coughs that interfere with daily activities and sleep.

Amazon Basic Care Maximum Strength Mucus DM tablets are designed for those suffering from coughs and chest congestion, making them a solid choice for anyone looking for relief from a cold. The combination of dextromethorphan HBr, a cough suppressant, and guaifenesin, an expectorant, effectively addresses both dry and productive coughs. With a maximum strength formula, these tablets can provide extended relief for up to 12 hours, which is beneficial for those who need uninterrupted rest at night.

The active ingredients work together to ease the intensity of coughing while also helping to clear mucus, making coughs more productive. This dual action can be particularly useful for individuals dealing with both a cough and chest congestion, providing a more comprehensive approach to cold symptoms.

In terms of convenience, the extended-release formulation means that individuals don’t have to take the medication as frequently, which can be a plus. But, depending on personal needs, some might prefer other forms of medication, such as liquids or lozenges, which could provide quicker relief.