10 Best Cough Syrups 2025 in the United States

Beekeeper's Naturals Propolis Honey Cough Syrup is designed to support immune function and soothe throats, making it a good choice for adults dealing with dry, scratchy throats and dry coughs. The syrup contains natural ingredients such as buckwheat honey, elderberry, chaga, and bee propolis, which are known for their immune-boosting properties.

This makes the syrup not just a remedy for coughs, but also a way to support immune health. The absence of alcohol and reliance on natural sweeteners like honey may appeal to those looking for a clean and natural product. However, it’s important to note that the syrup has a specific flavor profile, dominated by honey and elderberry, which may not suit everyone’s taste.

The product is packaged in a 4-ounce bottle, making it relatively easy to carry and use. This cough syrup offers a natural alternative to traditional cough medicines, emphasizing immune support and throat soothing with clean ingredients.

The Delsym 12 Hour Cough and Nighttime Fast Relief combo offers a two-part solution for managing coughs, especially useful for those who need long-lasting daytime relief and a separate formula to help with nighttime symptoms. The 12 Hour Cough syrup features Dextromethorphan Polistirex, an effective cough suppressant that works up to 12 hours, which is great for reducing frequent coughing during the day. It’s alcohol-free, which is a plus for people avoiding alcohol-based medicines, and comes in a mild orange flavor that tends to be pleasant for most users.

The Nighttime Fast Relief syrup targets multiple symptoms including cough, minor aches, fever, and runny nose by combining Dextromethorphan HBr, Acetaminophen, and Triprolidine (an antihistamine). This makes it a good choice for use before bed to encourage rest, although the presence of multiple active ingredients means it should be used carefully according to dosage instructions. The combo pack does not clearly state sugar content, which may be a concern for those monitoring sugar intake. Also, since the Nighttime formula contains acetaminophen, users must avoid doubling up on other acetaminophen products to prevent overdose. Users should check age recommendations on the packaging, especially for children.

This combo pack suits individuals looking for a trusted pharmacist-recommended brand that covers both persistent daytime coughs and nighttime symptoms. It may be less ideal if you prefer a single medicine for all symptoms or need a sugar-free option. Delsym provides reliable cough suppression with added relief for nighttime discomfort, making it a practical choice for many adults and older children.

Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine is crafted for adults seeking relief from multiple cold and flu symptoms. The combo pack includes two liquids, one for daytime use and one for nighttime, each targeting specific issues effectively. The daytime formula helps relieve chest congestion with Guaifenesin, while the nighttime version includes an antihistamine to tackle runny noses and sneezing. Both formulations contain Acetaminophen for fever and pain relief, along with Dextromethorphan HBr to suppress cough.

One notable strength is its comprehensive approach to cold and flu symptoms, making it suitable for those suffering from a range of issues at once. The trusted Mucinex brand further adds to its credibility, backed by recommendations from doctors and pharmacists. It’s also important to note that it is designated for individuals aged 12 and older, making it appropriate for many adults.

Potential drawbacks include its alcohol and sugar content, which may be a concern for some users. The nighttime formula, while effective, could lead to drowsiness due to the antihistamine ingredient, which might not be ideal for everyone. Additionally, while the product is designed for adults, parents looking for cold relief for younger children will need to seek alternatives, as this is not suitable for those under 12.