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10 Best Digestive Enzymes 2025 in the United States

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Our Top Picks

#1

Winner

Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, 30 Capsules

Rating
10.0
Chosen by1,127
Enzyme Activity

Most important from
9194 reviews

Enzyme Activity
The addition of digestive enzymes helps break down food effectively, reducing bloating and gas while improving nutrient absorption.

The Raw Probiotics by Garden of Life offers a robust combination of 100 billion CFU of probiotics and various digestive enzymes, making it a strong contender in the digestive health category. With 34 clinically studied strains, including well-known probiotics like B. lactis and L. acidophilus, this product aims to restore beneficial bacteria in the gut, which can be particularly beneficial for those looking to improve their digestive health. The inclusion of a protein-digesting enzyme blend (Protease) further supports digestion and nutrient absorption, catering to individuals with dietary sensitivities or those who have difficulty digesting certain foods.

One of the standout features is its shelf-stable formulation, which means it can maintain its potency without refrigeration, making it convenient for travel and daily use. Its gluten-free formulation and the addition of raw fruits and vegetables appeal to health-conscious consumers seeking whole food supplements.

Potential drawbacks include the capsule form, which might not be suitable for individuals who have difficulty swallowing pills. Additionally, while the high CFU count is impressive, some users may not notice immediate digestive benefits, as results can vary from person to person. Lastly, since it includes additional ingredients, individuals with specific allergies or sensitivities should carefully review the label.

Rating
10.0
Chosen by1,127
Enzyme Activity

Most important from
9194 reviews

Enzyme Activity
The addition of digestive enzymes helps break down food effectively, reducing bloating and gas while improving nutrient absorption.
#2

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE Digestive Enzymes stands out in the digestive health category with its comprehensive blend of 16 enzymes designed to tackle proteins, carbs, fruits, vegetables, beans, dairy, and fats. This makes it a versatile option for many diets, addressing a range of digestive issues. The addition of soil-based probiotics and organic prebiotics enhances its effectiveness, promoting not just relief from meal-time discomfort but also supporting gut health.

One of the major strengths of this product is its dual-action approach. While the enzymes break down food efficiently, the probiotics help maintain a balanced gut flora, potentially leading to improved digestive function over time. The formulation is backed by scientific research, which adds credibility, especially for those looking for evidence-based health solutions. Additionally, the product is third-party tested for quality, which is reassuring for consumers concerned about safety and potency.

On the downside, while the product is vegan and does not require refrigeration, some users might find the capsule form less convenient compared to chewable options. Also, individuals with specific dietary restrictions should carefully review the ingredient list, as even organic compounds can sometimes cause sensitivities. The product’s effectiveness can vary from person to person; some might experience noticeable relief, while others might not see significant benefits.

#3

Zenwise Health Digestive Enzymes and Bromelain for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief for Digestion - 180 CT

Rating
9.8
Additional Ingredients

Most important from
70682 reviews

Additional Ingredients
A unique combination of enzymes and probiotics in these pills helps regulate gut health effectively and immediately.

Zenwise Health Digestive Enzymes are designed to support digestive health for both men and women. They combine a unique blend of plant-based enzymes, probiotics, and prebiotics, making them a solid option for anyone looking to enhance their digestion and reduce bloating. One key strength of this product is its 3-in-1 formula, which targets the breakdown of proteins, fats, and carbohydrates. This can lead to more efficient nutrient absorption and may help alleviate discomfort from indigestion. Users will appreciate the quick action of these enzymes, promising noticeable relief from digestive issues soon after consumption.

Another advantage is the inclusion of proven probiotics that reach the small intestine alive, which is crucial for effective nutrient absorption. Those who suffer from gas and bloating may find additional relief thanks to the targeted enzymes that work to soothe these common issues.

On the downside, while the product is vegetarian and utilizes plant-based ingredients, some users might prefer a broader range of enzyme types or higher enzyme activity levels. Additionally, results can vary based on individual digestive systems—some may experience significant benefits while others may find it less effective. The capsule form, while convenient, may not be suitable for everyone, especially those who prefer chewable or liquid options.

Rating
9.8
Additional Ingredients

Most important from
70682 reviews

Additional Ingredients
A unique combination of enzymes and probiotics in these pills helps regulate gut health effectively and immediately.

Buying Guide for the Best Digestive Enzymes

Digestive enzymes are supplements that help your body break down and digest food more effectively. They can be particularly useful for individuals with digestive disorders or those who experience discomfort after eating certain foods. When choosing a digestive enzyme supplement, it's important to consider several key specifications to ensure you select the right product for your needs. Understanding these specifications will help you make an informed decision and improve your digestive health.
Enzyme TypesDigestive enzymes come in various types, each targeting different components of food. The main types include proteases (for proteins), lipases (for fats), and amylases (for carbohydrates). Some supplements also contain lactase (for lactose) and cellulase (for fiber). It's important to choose a supplement that contains the enzymes you need based on your dietary habits and any specific digestive issues you may have. For example, if you have trouble digesting dairy, look for a product with lactase.
Enzyme SourceDigestive enzymes can be derived from different sources, including animal, plant, and microbial origins. Animal-based enzymes, like pancreatin, are often more potent but may not be suitable for vegetarians or vegans. Plant-based enzymes, such as bromelain (from pineapple) and papain (from papaya), are suitable for most diets and can be gentler on the stomach. Microbial enzymes, derived from fungi or bacteria, are highly effective and suitable for all dietary preferences. Choose a source that aligns with your dietary restrictions and personal preferences.
Enzyme ActivityEnzyme activity is measured in units that indicate the potency of the enzyme. Higher activity levels mean the enzyme can break down more food in a shorter amount of time. This is important for individuals with severe digestive issues who need more potent support. However, for general digestive support, moderate activity levels may be sufficient. Check the label for activity units and choose a product that matches the severity of your digestive needs.
Additional IngredientsSome digestive enzyme supplements include additional ingredients like probiotics, prebiotics, or herbal extracts to further support digestive health. Probiotics are beneficial bacteria that help maintain a healthy gut flora, while prebiotics are fibers that feed these bacteria. Herbal extracts like ginger or peppermint can soothe the digestive tract. If you have specific digestive concerns, such as bloating or irregularity, look for a supplement that includes these additional ingredients.
Form and DosageDigestive enzymes are available in various forms, including capsules, tablets, powders, and chewables. The form you choose should be convenient for your lifestyle and easy for you to take regularly. Dosage recommendations can vary, so it's important to follow the instructions on the label or consult with a healthcare professional. Some people may need to take enzymes with every meal, while others may only need them occasionally. Consider your eating habits and digestive needs when selecting the form and dosage.

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