10 Best Digestive Enzymes 2025 in the United States

Zenwise Health Digestive Enzymes are designed to support digestive health for both men and women. They combine a unique blend of plant-based enzymes, probiotics, and prebiotics, making them a solid option for anyone looking to enhance their digestion and reduce bloating. One key strength of this product is its 3-in-1 formula, which targets the breakdown of proteins, fats, and carbohydrates. This can lead to more efficient nutrient absorption and may help alleviate discomfort from indigestion. Users will appreciate the quick action of these enzymes, promising noticeable relief from digestive issues soon after consumption.

Another advantage is the inclusion of proven probiotics that reach the small intestine alive, which is crucial for effective nutrient absorption. Those who suffer from gas and bloating may find additional relief thanks to the targeted enzymes that work to soothe these common issues.

On the downside, while the product is vegetarian and utilizes plant-based ingredients, some users might prefer a broader range of enzyme types or higher enzyme activity levels. Additionally, results can vary based on individual digestive systems—some may experience significant benefits while others may find it less effective. The capsule form, while convenient, may not be suitable for everyone, especially those who prefer chewable or liquid options.

The Physician's CHOICE Advanced Gut Health Bundle combines a strong 60 billion CFU probiotic with digestive enzymes in an easy-to-take capsule form, designed to support digestive, gut, and immune health. This bundle targets common digestive problems such as occasional constipation, diarrhea, gas, and bloating, making it a solid option for those experiencing general digestive discomfort.

The included digestive enzymes help your body break down food more efficiently, which can improve nutrient absorption—a key factor if you want to get the most from your diet. The probiotic’s ability to survive the digestive tract helps beneficial bacteria establish themselves in your gut for longer-lasting effects.

By combining two popular supplements, this bundle offers convenience and value, potentially saving you money compared to buying each separately. For those wanting a general digestive aid with both probiotics and enzymes in one package, this bundle is a practical and approachable choice.

The Raw Probiotics by Garden of Life offers a robust combination of 100 billion CFU of probiotics and various digestive enzymes, making it a strong contender in the digestive health category. With 34 clinically studied strains, including well-known probiotics like B. lactis and L. acidophilus, this product aims to restore beneficial bacteria in the gut, which can be particularly beneficial for those looking to improve their digestive health. The inclusion of a protein-digesting enzyme blend (Protease) further supports digestion and nutrient absorption, catering to individuals with dietary sensitivities or those who have difficulty digesting certain foods.

One of the standout features is its shelf-stable formulation, which means it can maintain its potency without refrigeration, making it convenient for travel and daily use. Its gluten-free formulation and the addition of raw fruits and vegetables appeal to health-conscious consumers seeking whole food supplements.

Potential drawbacks include the capsule form, which might not be suitable for individuals who have difficulty swallowing pills. Additionally, while the high CFU count is impressive, some users may not notice immediate digestive benefits, as results can vary from person to person. Lastly, since it includes additional ingredients, individuals with specific allergies or sensitivities should carefully review the label.