10 Best Digestive Enzymes 2025 in the United States

Zenwise Health Digestive Enzymes are designed to support digestive health for both men and women. They combine a unique blend of plant-based enzymes, probiotics, and prebiotics, making them a solid option for anyone looking to enhance their digestion and reduce bloating. One key strength of this product is its 3-in-1 formula, which targets the breakdown of proteins, fats, and carbohydrates. This can lead to more efficient nutrient absorption and may help alleviate discomfort from indigestion. Users will appreciate the quick action of these enzymes, promising noticeable relief from digestive issues soon after consumption.

Another advantage is the inclusion of proven probiotics that reach the small intestine alive, which is crucial for effective nutrient absorption. Those who suffer from gas and bloating may find additional relief thanks to the targeted enzymes that work to soothe these common issues.

On the downside, while the product is vegetarian and utilizes plant-based ingredients, some users might prefer a broader range of enzyme types or higher enzyme activity levels. Additionally, results can vary based on individual digestive systems—some may experience significant benefits while others may find it less effective. The capsule form, while convenient, may not be suitable for everyone, especially those who prefer chewable or liquid options.

The Raw Probiotics by Garden of Life offers a robust combination of 100 billion CFU of probiotics and various digestive enzymes, making it a strong contender in the digestive health category. With 34 clinically studied strains, including well-known probiotics like B. lactis and L. acidophilus, this product aims to restore beneficial bacteria in the gut, which can be particularly beneficial for those looking to improve their digestive health. The inclusion of a protein-digesting enzyme blend (Protease) further supports digestion and nutrient absorption, catering to individuals with dietary sensitivities or those who have difficulty digesting certain foods.

One of the standout features is its shelf-stable formulation, which means it can maintain its potency without refrigeration, making it convenient for travel and daily use. Its gluten-free formulation and the addition of raw fruits and vegetables appeal to health-conscious consumers seeking whole food supplements.

Potential drawbacks include the capsule form, which might not be suitable for individuals who have difficulty swallowing pills. Additionally, while the high CFU count is impressive, some users may not notice immediate digestive benefits, as results can vary from person to person. Lastly, since it includes additional ingredients, individuals with specific allergies or sensitivities should carefully review the label.

Physician's CHOICE Digestive Enzymes stands out in the digestive health category with its comprehensive blend of 16 enzymes designed to tackle proteins, carbs, fruits, vegetables, beans, dairy, and fats. This makes it a versatile option for many diets, addressing a range of digestive issues. The addition of soil-based probiotics and organic prebiotics enhances its effectiveness, promoting not just relief from meal-time discomfort but also supporting gut health.

One of the major strengths of this product is its dual-action approach. While the enzymes break down food efficiently, the probiotics help maintain a balanced gut flora, potentially leading to improved digestive function over time. The formulation is backed by scientific research, which adds credibility, especially for those looking for evidence-based health solutions. Additionally, the product is third-party tested for quality, which is reassuring for consumers concerned about safety and potency.

On the downside, while the product is vegan and does not require refrigeration, some users might find the capsule form less convenient compared to chewable options. Also, individuals with specific dietary restrictions should carefully review the ingredient list, as even organic compounds can sometimes cause sensitivities. The product’s effectiveness can vary from person to person; some might experience noticeable relief, while others might not see significant benefits.