We Use CookiesWe use cookies to enhance the security, performance, functionality and for analytical and promotional activities. By continuing to browse this site you are agreeing to our privacy policy

10 Best Digestive Enzymes 2025 in the United States

How do we rank products for you?

Our technology thoroughly searches through the online shopping world, reviewing hundreds of sites. We then process and analyze this information, updating in real-time to bring you the latest top-rated products. This way, you always get the best and most current options available.

headphones-stars

Our Top Picks

#1

Winner

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Rating
10.0
Chosen by1,206
Additional Ingredients

Most important from
72836 reviews

Additional Ingredients
A unique combination of enzymes and probiotics in these pills helps regulate gut health effectively and immediately.

Zenwise Health Digestive Enzymes are designed to support digestive health for both men and women. They combine a unique blend of plant-based enzymes, probiotics, and prebiotics, making them a solid option for anyone looking to enhance their digestion and reduce bloating. One key strength of this product is its 3-in-1 formula, which targets the breakdown of proteins, fats, and carbohydrates. This can lead to more efficient nutrient absorption and may help alleviate discomfort from indigestion. Users will appreciate the quick action of these enzymes, promising noticeable relief from digestive issues soon after consumption.

Another advantage is the inclusion of proven probiotics that reach the small intestine alive, which is crucial for effective nutrient absorption. Those who suffer from gas and bloating may find additional relief thanks to the targeted enzymes that work to soothe these common issues.

On the downside, while the product is vegetarian and utilizes plant-based ingredients, some users might prefer a broader range of enzyme types or higher enzyme activity levels. Additionally, results can vary based on individual digestive systems—some may experience significant benefits while others may find it less effective. The capsule form, while convenient, may not be suitable for everyone, especially those who prefer chewable or liquid options.

Rating
10.0
Chosen by1,206
Additional Ingredients

Most important from
72836 reviews

Additional Ingredients
A unique combination of enzymes and probiotics in these pills helps regulate gut health effectively and immediately.
#2

Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, Shelf Stable, 30 Capsules

Rating
7.9
Enzyme Activity

Most important from
10796 reviews

Enzyme Activity
The addition of digestive enzymes helps break down food effectively, reducing bloating and gas while improving nutrient absorption.

The Raw Probiotics by Garden of Life offers a robust combination of 100 billion CFU of probiotics and various digestive enzymes, making it a strong contender in the digestive health category. With 34 clinically studied strains, including well-known probiotics like B. lactis and L. acidophilus, this product aims to restore beneficial bacteria in the gut, which can be particularly beneficial for those looking to improve their digestive health. The inclusion of a protein-digesting enzyme blend (Protease) further supports digestion and nutrient absorption, catering to individuals with dietary sensitivities or those who have difficulty digesting certain foods.

One of the standout features is its shelf-stable formulation, which means it can maintain its potency without refrigeration, making it convenient for travel and daily use. Its gluten-free formulation and the addition of raw fruits and vegetables appeal to health-conscious consumers seeking whole food supplements.

Potential drawbacks include the capsule form, which might not be suitable for individuals who have difficulty swallowing pills. Additionally, while the high CFU count is impressive, some users may not notice immediate digestive benefits, as results can vary from person to person. Lastly, since it includes additional ingredients, individuals with specific allergies or sensitivities should carefully review the label.

Rating
7.9
Enzyme Activity

Most important from
10796 reviews

Enzyme Activity
The addition of digestive enzymes helps break down food effectively, reducing bloating and gas while improving nutrient absorption.
#3

Garden of Life 21 Powerful Digestive Enzymes with Papain, Bromelain, Lipase, Ginger, Turmeric for Complete Digestion of Protein, Carbs & Fats – Omega-Zyme Ultra, Gluten-Free, Vegetarian, 180 Capsules

Rating
7.6
Form and Dosage

Most important from
1236 reviews

Form and Dosage
Finding the right dosage is key; for heavy meals, 3 capsules do the trick, while lighter meals require just 1 or 2.

The Garden of Life Vegetarian Digestive Supplement - Omega Zyme Ultra Enzyme Blend is designed to support digestive health comprehensively. It boasts a robust formula containing 21 different digestive enzymes, which can play a significant role in breaking down a wide range of foods, aiding in digestion, and addressing issues like bloating, gas, and IBS. This broad-spectrum enzyme activity is optimized across the varying pH levels of the gastrointestinal tract, which can be beneficial for thorough digestion throughout the entire digestive system.

The inclusion of plant-based and ocean-based trace minerals may further enhance its nutritional value. The vegetarian capsules dissolve quickly for rapid nutrient release, which is particularly advantageous for those seeking quick relief and support. The product is also gluten-free, dairy-free, and free from artificial colors and preservatives, making it suitable for individuals with specific dietary restrictions or sensitivities. However, it should be noted that at 180 capsules per bottle, the dosage may vary based on individual needs, and consulting with a healthcare professional is recommended to determine the suitable intake.

The fact that it is unflavored is a plus for those who prefer no added flavors, but it might be less appealing to those who prefer some taste in their supplements. Made in the U.S.A., this product aligns well with those who prioritize locally manufactured health products. The Garden of Life Omega Zyme Ultra Enzyme Blend is a strong contender for anyone seeking comprehensive digestive enzyme support, particularly adults who suffer from digestive discomforts.

Rating
7.6
Form and Dosage

Most important from
1236 reviews

Form and Dosage
Finding the right dosage is key; for heavy meals, 3 capsules do the trick, while lighter meals require just 1 or 2.

Buying Guide for the Best Digestive Enzymes

Digestive enzymes are supplements that help your body break down and digest food more effectively. They can be particularly useful for individuals with digestive disorders or those who experience discomfort after eating certain foods. When choosing a digestive enzyme supplement, it's important to consider several key specifications to ensure you select the right product for your needs. Understanding these specifications will help you make an informed decision and improve your digestive health.
Enzyme TypesDigestive enzymes come in various types, each targeting different components of food. The main types include proteases (for proteins), lipases (for fats), and amylases (for carbohydrates). Some supplements also contain lactase (for lactose) and cellulase (for fiber). It's important to choose a supplement that contains the enzymes you need based on your dietary habits and any specific digestive issues you may have. For example, if you have trouble digesting dairy, look for a product with lactase.
Enzyme SourceDigestive enzymes can be derived from different sources, including animal, plant, and microbial origins. Animal-based enzymes, like pancreatin, are often more potent but may not be suitable for vegetarians or vegans. Plant-based enzymes, such as bromelain (from pineapple) and papain (from papaya), are suitable for most diets and can be gentler on the stomach. Microbial enzymes, derived from fungi or bacteria, are highly effective and suitable for all dietary preferences. Choose a source that aligns with your dietary restrictions and personal preferences.
Enzyme ActivityEnzyme activity is measured in units that indicate the potency of the enzyme. Higher activity levels mean the enzyme can break down more food in a shorter amount of time. This is important for individuals with severe digestive issues who need more potent support. However, for general digestive support, moderate activity levels may be sufficient. Check the label for activity units and choose a product that matches the severity of your digestive needs.
Additional IngredientsSome digestive enzyme supplements include additional ingredients like probiotics, prebiotics, or herbal extracts to further support digestive health. Probiotics are beneficial bacteria that help maintain a healthy gut flora, while prebiotics are fibers that feed these bacteria. Herbal extracts like ginger or peppermint can soothe the digestive tract. If you have specific digestive concerns, such as bloating or irregularity, look for a supplement that includes these additional ingredients.
Form and DosageDigestive enzymes are available in various forms, including capsules, tablets, powders, and chewables. The form you choose should be convenient for your lifestyle and easy for you to take regularly. Dosage recommendations can vary, so it's important to follow the instructions on the label or consult with a healthcare professional. Some people may need to take enzymes with every meal, while others may only need them occasionally. Consider your eating habits and digestive needs when selecting the form and dosage.

FAQ

Most Popular Categories Right Now