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10 Best Enzyme Cleaner For Cat Pee 2025 in the United States

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Our Top Picks

#1

Winner

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover for Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray For Home, Puppy Potty Training

Rating
9.9
Chosen by1,383
Enzyme Type
Surface Compatibility
Scent

Most important from
121178 reviews

Enzyme Type
If a cat pees on something you love, just try, try again. Miraculously ammonia-free clean stuff.
Surface Compatibility
I've used it on hardwood, wooden chests, carpet, clothing, couch fabric, cabinets, and even outside, and it never stained or damaged any surfaces.
Scent
The smell of pee and cat spray went away almost instantly, and none of my cats are interested in going back to those spots any longer.

Rocco & Roxie Extreme Stain & Odor Eliminator is a versatile enzyme cleaner designed to tackle tough pet stains and odors, including cat pee. It combines a potent bio-enzymatic formula with a mineral-based odor neutralizer to effectively eliminate ammonia crystals and organic matter. The cleaner is suitable for various surfaces like carpets, floors, furniture, clothing, and pet bedding, making it a handy tool for pet owners.

Its subtle Meyer lemon scent ensures a fresh environment without being overpowering and it dries reasonably fast after application. Additionally, the product is chlorine-free, color-safe, and certified safe for use around pets and children, receiving the Carpet and Rug Institute's Seal of Approval. This shows its gentle nature while still being effective.

While its eco-friendliness stems from being chlorine-free and using no hazardous propellants, some users might prefer a product with explicit eco-certifications. The return and satisfaction policies are clear, offering peace of mind for buyers. However, it's essential to purchase from authorized retailers to benefit from these guarantees. This product is highly effective for removing tough pet stains and odors, making it ideal for households with pets, particularly those dealing with frequent accidents.

Rating
9.9
Chosen by1,383
Enzyme Type
Surface Compatibility
Scent

Most important from
121178 reviews

Enzyme Type
If a cat pees on something you love, just try, try again. Miraculously ammonia-free clean stuff.
Surface Compatibility
I've used it on hardwood, wooden chests, carpet, clothing, couch fabric, cabinets, and even outside, and it never stained or damaged any surfaces.
Scent
The smell of pee and cat spray went away almost instantly, and none of my cats are interested in going back to those spots any longer.
#2

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

The Rocco & Roxie Stain & Odor Eliminator is an enzyme cleaner designed specifically to tackle tough pet odors, including cat urine. It uses natural enzymes that activate when sprayed, breaking down urine and organic stains at their source rather than just masking the smell. The product is safe for use around pets and children, as it is free from chlorine and harsh chemicals. It is also certified safe for all carpet types, helping to avoid damage to flooring.

This cleaner is versatile and can be used on a variety of surfaces beyond carpet, such as furniture, floors, clothing, and pet bedding, making it suitable for many household messes. The scent is described as “original,” indicating a mild, non-overpowering smell that is unlikely to be unpleasant once dry. The product is eco-friendly, relying on natural enzymes and no harmful propellants, making it a more environmentally conscious choice compared to chemical cleaners.

The bottle size is 32 ounces, which is moderate; users with multiple pets or large areas to treat might need to replenish more frequently. Rocco & Roxie Stain & Odor Eliminator is a reliable, safe, and natural enzyme cleaner for cat urine and other organic stains around the home.

#3

ANGRY ORANGE Pet Odor Eliminator for Cat Urine, Carpet Stains, and Strong Smells – Fresh Scent Odor Remover- 24 oz

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
125002 reviews

Enzyme Type
Effectively eliminates even the toughest cat urine odors with no return of the smell, providing a level of odor control unmatched by other products or professional cleaning.
Application Method
A small amount goes a long way—just a few sprays completely neutralize odors without needing to soak or repeat treatments.
Surface Compatibility
Works well on hard surfaces and carpets, and when combined with other cleaning methods like baking soda and airflow, it completely removes deeply embedded urine smells.
Scent
The fresh citrus scent is pleasant and noticeable, often earning compliments from visitors who can't detect any trace of pet odors despite multiple cats in the home.
Eco-Friendliness
Safe to use around pets when directions are followed, with no harsh chemicals, making it a reassuring choice for eco-conscious pet owners.

ANGRY ORANGE Pet Odor Eliminator is designed to tackle strong pet odors, including cat urine, with a fresh scent that many pet owners will appreciate. It works quickly to neutralize and remove odors at their source, which benefits anyone struggling with persistent cat pee smells. The spray form makes it easy to apply directly on hard and sealed surfaces such as floors and carpets where accidents often happen.

It is safe to use around pets when directions are followed and contains no harsh chemicals like parabens or sulfates, which is reassuring for eco-conscious users. This product suits cat owners looking for a convenient spray that removes stains and odors on common surfaces safely and with a pleasant smell.

Those needing enzyme-specific details or usage on delicate fabrics might want to investigate further.

Rating
9.7
Enzyme Type
Application Method
Surface Compatibility

Most important from
125002 reviews

Enzyme Type
Effectively eliminates even the toughest cat urine odors with no return of the smell, providing a level of odor control unmatched by other products or professional cleaning.
Application Method
A small amount goes a long way—just a few sprays completely neutralize odors without needing to soak or repeat treatments.
Surface Compatibility
Works well on hard surfaces and carpets, and when combined with other cleaning methods like baking soda and airflow, it completely removes deeply embedded urine smells.
Scent
The fresh citrus scent is pleasant and noticeable, often earning compliments from visitors who can't detect any trace of pet odors despite multiple cats in the home.
Eco-Friendliness
Safe to use around pets when directions are followed, with no harsh chemicals, making it a reassuring choice for eco-conscious pet owners.

Buying Guide for the Best Enzyme Cleaner For Cat Pee

Choosing the right enzyme cleaner for cat pee can make a significant difference in maintaining a clean and odor-free home. Enzyme cleaners are specifically designed to break down the proteins in cat urine, eliminating both the stain and the odor. When selecting an enzyme cleaner, it's important to consider several key specifications to ensure you get the best product for your needs. Understanding these specifications will help you make an informed decision and keep your home fresh and clean.
Enzyme TypeEnzyme type refers to the specific enzymes used in the cleaner to break down the urine. This is important because different enzymes target different components of the urine. Common enzymes include proteases, which break down proteins, and amylases, which break down starches. For cat urine, proteases are particularly effective. When choosing an enzyme cleaner, look for one that specifically mentions it targets pet urine or cat urine to ensure it contains the right enzymes for the job.
Application MethodThe application method refers to how the cleaner is applied to the affected area. This can include spray bottles, pour bottles, or even powders. The method is important because it affects how easy and effective the cleaner is to use. Spray bottles are convenient for small spots and quick applications, while pour bottles might be better for larger areas or deep cleaning. Consider the size of the area you need to clean and how frequently you will be using the product to determine the best application method for you.
Surface CompatibilitySurface compatibility indicates which surfaces the enzyme cleaner can be safely used on. This is crucial because using the wrong cleaner on certain surfaces can cause damage. Common surfaces include carpets, upholstery, hardwood floors, and tiles. Check the product label to ensure it is safe for the surfaces you need to clean. If you have multiple types of surfaces, look for a versatile cleaner that works on all of them to avoid having to buy multiple products.
ScentThe scent of the enzyme cleaner can affect your overall satisfaction with the product. Some cleaners have a strong fragrance to mask odors, while others are unscented. If you or your pets are sensitive to strong smells, an unscented or lightly scented cleaner might be preferable. On the other hand, if you want a fresh-smelling home, a cleaner with a pleasant fragrance can be a good choice. Consider your personal preference and any sensitivities when choosing the scent of your enzyme cleaner.
Drying TimeDrying time refers to how long it takes for the cleaned area to dry after application. This is important because it affects how quickly you can use the area again and how effective the cleaning process is. Faster drying times are convenient and reduce the risk of mold or mildew, especially in humid environments. However, some cleaners may require a longer drying time to fully break down the urine components. Consider your schedule and the urgency of the cleaning task when evaluating drying times.
Eco-FriendlinessEco-friendliness indicates whether the enzyme cleaner is environmentally friendly and safe for pets and humans. This is important for those who are conscious about their environmental impact and the health of their household. Look for products that are biodegradable, non-toxic, and free from harsh chemicals. Eco-friendly cleaners are generally safer for use around pets and children and contribute to a healthier home environment. If sustainability is a priority for you, choose a cleaner that meets these criteria.

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