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10 Best Enzyme Cleaners 2025 in the United States

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Our Top Picks

#1

Winner

Angry Orange Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 1 Gallon

Rating
10.0
Chosen by1,435
Odor Elimination Ability
Concentration and Dilution
Scent

Most important from
127738 reviews

Odor Elimination Ability
Completely eliminates tough pet odors like cat urine with no return of the smell, even after repeated use.
Concentration and Dilution
A small amount goes a long way, requiring a change in cleaning habits to avoid wasting the concentrated formula.
Scent
Leaves a fresh, pleasant citrus scent that impresses visitors and masks typical pet smells effectively.
Application Surface
Works quickly and thoroughly on old urine stains, restoring carpets without lingering odors or visible stains.

Angry Orange Pet Odor Eliminator is designed to tackle tough pet odors like urine, feces, and vomit, making it a solid choice for pet owners dealing with strong smells. It uses natural orange oil as its scent base, which provides a fresh citrus aroma without harsh chemical odors, making it pleasant to use around the home. The cleaner works well on hard and sealed surfaces, such as floors, where pet messes commonly occur.

Safety-wise, it avoids harsh chemicals like parabens, sulfates, and phthalates, which is a plus for homes with pets and children. The gallon size is convenient for frequent use or refilling smaller spray bottles, offering good value.

This product suits pet owners looking for a safe, natural-smelling cleaner that handles odor elimination on hard surfaces, though those needing enzyme-specific details or use on fabrics and carpets might want to look further.

Rating
10.0
Chosen by1,435
Odor Elimination Ability
Concentration and Dilution
Scent

Most important from
127738 reviews

Odor Elimination Ability
Completely eliminates tough pet odors like cat urine with no return of the smell, even after repeated use.
Concentration and Dilution
A small amount goes a long way, requiring a change in cleaning habits to avoid wasting the concentrated formula.
Scent
Leaves a fresh, pleasant citrus scent that impresses visitors and masks typical pet smells effectively.
Application Surface
Works quickly and thoroughly on old urine stains, restoring carpets without lingering odors or visible stains.
#2

ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz - Value 2 Pack

Rating
9.1
Odor Elimination Ability
Concentration and Dilution
Scent

Most important from
127738 reviews

Odor Elimination Ability
This product completely eliminates the smell of cat urine without the odor ever returning, even in challenging cases like incontinent cats.
Concentration and Dilution
A little goes a long way—just a few sprays are enough to clean and kill odors, making it surprisingly concentrated and efficient.
Scent
The fresh citrus scent is pleasant and lasts about 12 hours, earning compliments from visitors who couldn't even tell there were cats in the house.
Application Surface
It works exceptionally well on hard surfaces, effectively removing tough pet odors where other cleaners and professional treatments have failed.

Angry Orange Pet Odor Eliminator is designed to tackle tough pet odors, especially from dog and cat urine, feces, and vomit. It works well on hard and sealed surfaces such as floors, making it a good choice for pet owners who need to clean and deodorize common mess areas. One of its main strengths is the use of natural orange oil for its citrus scent, which provides a fresh smell without harsh chemical odors. This can be more pleasant than many other enzyme cleaners that sometimes have strong or artificial fragrances.

The product is safe to use around pets when directions are followed, as it contains no parabens, sulfates, or phthalates, which reassures users concerned about harsh chemicals. It comes in a convenient spray form and a value pack of two 24-ounce bottles, offering enough solution for multiple cleaning tasks. The scent lasts about 12 hours, which helps maintain freshness between cleanings. It is best suited for hard surfaces rather than carpets or fabrics, so it may not replace specialized carpet enzyme cleaners for deep fabric cleaning.

If you want a safe, citrus-scented enzyme cleaner mostly for hard surfaces and effective odor elimination without harsh chemicals, Angry Orange is a solid pick. For more specialized needs like fabric cleaning, you might want to explore other options.

Rating
9.1
Odor Elimination Ability
Concentration and Dilution
Scent

Most important from
127738 reviews

Odor Elimination Ability
This product completely eliminates the smell of cat urine without the odor ever returning, even in challenging cases like incontinent cats.
Concentration and Dilution
A little goes a long way—just a few sprays are enough to clean and kill odors, making it surprisingly concentrated and efficient.
Scent
The fresh citrus scent is pleasant and lasts about 12 hours, earning compliments from visitors who couldn't even tell there were cats in the house.
Application Surface
It works exceptionally well on hard surfaces, effectively removing tough pet odors where other cleaners and professional treatments have failed.
#3

Nature’s Miracle Advanced Stain And Odor Eliminator for Dogs, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes, 1 Gallon

Rating
8.8
Odor Elimination Ability
Scent

Most important from
3339 reviews

Odor Elimination Ability
Effectively eliminates urine stains and odors, making it a must-have for pet owners.
Scent
The scent is fresh and not overpowering, which helps maintain a pleasant home environment.

Nature’s Miracle Advanced Stain And Odor Eliminator is designed to tackle tough pet messes, especially for dog owners dealing with severe stains and odors. It uses an enzymatic formula, which means it breaks down organic materials rather than just masking smells. This product works on multiple surfaces like carpets, hard floors, furniture, and even clothing, making it versatile for home use. It is effective at removing odors, which helps discourage pets from re-soiling treated areas. The fresh scent is light and not overpowering, which many users will appreciate.

The cleaner dries quickly, so you won’t have to wait long before the area is ready to use again. In terms of safety, it’s made for use around pets and adults, but as with all cleaners, it’s wise to follow instructions and avoid direct contact with eyes or ingestion. The product comes in a concentrated liquid form in a 1-gallon size, so you’ll have plenty for multiple uses, though you may need to dilute it depending on the cleaning job. The main downside is the size and weight; at 8 pounds, it might be bulky for some to handle and store. Also, while it is great for pet-related stains, it might be more than needed for light or non-pet stains.

If you want a strong, reliable enzymatic cleaner that covers a variety of surfaces and offers good odor control with a pleasant scent, this product represents a solid choice.

Rating
8.8
Odor Elimination Ability
Scent

Most important from
3339 reviews

Odor Elimination Ability
Effectively eliminates urine stains and odors, making it a must-have for pet owners.
Scent
The scent is fresh and not overpowering, which helps maintain a pleasant home environment.

Buying Guide for the Best Enzyme Cleaners

Choosing the best enzyme cleaner means finding one suited to the messes you tackle most often. These cleaners use natural enzymes to break down stains and odors—especially useful for organic messes like pet accidents, food spills, or laundry issues. Think about where and how you’ll use the product: for carpets, upholstery, laundry, or hard surfaces. The key is to blend effectiveness, safety, and ease-of-use so the cleaner can make life easier without compromise. Understanding some core specifications and choosing based on your needs will help you get the most value and satisfaction.
Type of EnzymesEnzyme cleaners contain different kinds of enzymes that target specific types of messes. Common types include proteases (for protein-based stains like blood and food), amylases (for starches like pasta, rice, or sauces), and lipases (for grease and oil). Some products blend all three for broad usage. If pet stains are your main problem, prioritize protease-based formulas. For greasy kitchens, lipase-heavy cleaners work best. Matching the enzyme type to your common messes ensures better cleaning results.
Application SurfaceMany enzyme cleaners are formulated for certain surfaces, such as carpets, upholstery, hard floors, or laundry. Some are multi-surface, while others are specialized. For best results, choose an enzyme cleaner that mentions compatibility with the surfaces you clean most. Using the right formulation helps avoid damage and increases stain-removal effectiveness, so always check the label for supported surfaces before purchasing.
Odor Elimination AbilityEnzyme cleaners usually do double duty, cleaning stains and neutralizing odors. Some are formulated specifically for powerful odor removal—for example, pet urine. To judge the effectiveness, look for claims of deep odor removal, not just masking. If strong smells are your biggest concern, prioritize products with robust odor-neutralizing abilities described on the packaging or in reviews.
Safety and IngredientsA crucial spec is the safety of the formula—especially if you have kids or pets. Many enzyme cleaners are non-toxic, biodegradable, and free of harsh chemicals, which makes them preferable in family environments. Navigate the product descriptions for phrases like 'safe for children/pets,' 'eco-friendly,' or 'biodegradable.' Opt for those if you value safety and environmental friendliness for your household.
Concentration and DilutionEnzyme cleaners often come either ready-to-use or concentrated. Concentrated formulas need to be diluted with water and can be more economical over time, while ready-to-use versions offer convenience. Decide based on your cleaning frequency—if you clean often or large areas, concentrated products give flexibility and can last longer; for quick spot treatments, ready-to-use is simpler.
ScentScent is worth considering if you're sensitive to fragrances or want a pleasant freshness after cleaning. Some enzyme cleaners have a mild, natural scent, others are fragrance-free, and some offer stronger, perfumed options. For those with allergies or preferences for a neutral environment, opt for unscented or lightly scented versions. Choose based on your tolerance and lifestyle for best comfort during and after cleaning.

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