10 Best Hand Sanitizers 2025 in the United States

The PURELL Advanced Hand Sanitizer Refreshing Gel is a strong contender in the hand sanitizer category, especially for high-traffic environments such as schools and offices. With 70% ethyl alcohol, it effectively kills 99.99% of germs, making it a reliable option for maintaining hygiene when soap and water aren't accessible. One of its significant strengths is the mild formula infused with moisturizers, which helps keep hands feeling soft even after frequent use. This is particularly beneficial for those who sanitize their hands often, as many sanitizers can be harsh and drying. Moreover, it is free from triclosan, parabens, phthalates, and preservatives, which is a plus for users who are conscious about the ingredients in their skincare products.

The clean scent adds to the experience, making it pleasant to use without being overwhelming. The 12 fl oz pump bottles are convenient for placement in areas where quick access to hand sanitization is needed, and since they come in a pack of 12, they offer good value for settings that require multiple dispensers.

The Purell Prime Defense Advanced Hand Sanitizer stands out for its high alcohol content, featuring 85% ethyl alcohol, which is effective at killing over 99.99% of germs. This makes it a strong contender for anyone looking for a reliable hand sanitizer, particularly beneficial for higher-risk environments such as offices, clinics, or public spaces. The professional-grade formulation offers added protection while being easy to use in a convenient pump bottle. The thinner gel consistency is a plus as it spreads easily and dries quickly, leaving hands feeling clean and refreshed. Additionally, Purell’s focus on skin health helps to combat dryness, making it suitable for frequent use without significant irritation.

However, the high alcohol content may not appeal to everyone, particularly those sensitive to strong fragrances or with dry skin issues, despite the moisturizing ingredients aiming to maintain skin health. The product is packaged in a bulk set of four 12 fl oz bottles, which is ideal for shared environments but may be excessive for personal use at home. Its size and weight could also be a consideration for those needing portable options, as these bottles are not the most travel-friendly.

The PURELL Advanced Hand Sanitizer Soothing Gel is a solid choice for those seeking a reliable hand-sanitizing solution. With an alcohol content of 70% ethyl alcohol, it is effective at eliminating germs while being gentle on the skin. The inclusion of vitamin E in the formulation helps to keep hands moisturized and soft, which is a big plus for frequent users as it prevents skin from drying out or becoming irritated.

Additionally, it’s free of parabens, phthalates, and preservatives, making it a safer option for those concerned about harsh chemicals. The fresh scent is pleasant and not overpowering, which should appeal to most users. Each pack includes four 8 fl oz pump bottles, making it convenient to place them in various locations such as desks, reception areas, and restrooms. This ensures that hand sanitizing is always within easy reach, promoting better hygiene practices among users.

However, the size of the bottles might not be the most portable for on-the-go use, as they are more suited for stationary placement. Also, while the product does boast outperforming other hand sanitizers ounce-for-ounce, it might come at a higher price point compared to some competing brands. The brand’s reputation and the quality of the product justify the cost for many, but it might be a consideration for budget-conscious buyers. This product is ideal for workplaces and common areas where maintaining hygiene is crucial, and it offers good value through its bulk packaging.