10 Best Laxatives For Severe Constipation 2025 in the United States

MiraLAX Gentle Constipation Relief is an osmotic laxative powder designed for individuals facing severe constipation. One of its main strengths is how it works naturally with the water in your body to hydrate and soften stools, making bowel movements easier without the harsh side effects often associated with stimulant laxatives. Users can expect results within 1 to 3 days, which is a reasonable timeframe for relief.

Physician recommendations back MiraLAX, having been the #1 OTC laxative brand since its launch in 2007. This level of trust may give users confidence in its effectiveness. Additionally, the product is free from gluten, sugar, and preservatives, making it a suitable choice for those with dietary restrictions.

On the downside, while the gentle action of MiraLAX is a plus, it may not provide immediate relief for individuals who need quicker results, as other types of laxatives may work faster. The powder must be dissolved in a beverage, which could be inconvenient for some users who prefer more straightforward forms of laxatives.

Prunelax Ciruelax Maximum Relief Laxative Tablets are designed to provide gentle, overnight relief for occasional constipation. These tablets work within 8-12 hours, making them a fast-acting option that can help you feel better by morning. They contain 250mg of natural Senna Leaf Extract, which is 66% stronger than the brand's regular strength version, ensuring more effective relief.

One significant advantage is that these tablets are vegan, gluten-free, and free from artificial additives, making them suitable for a variety of dietary needs. Another benefit is their predictability and ease of use; taking two tablets before bedtime is all it takes to maintain control over constipation comfortably. However, it’s important to note that Prunelax is intended for occasional use, which means it might not be suitable for those who suffer from chronic constipation.

Additionally, while the natural ingredients are generally gentle, some users might experience side effects such as stomach cramps or diarrhea. Prunelax Ciruelax offers a reliable and inclusive solution for those seeking fast, gentle relief from occasional constipation, but it's essential to use it as directed to avoid potential side effects.

Amazon Basic Care ClearLax is an osmotic laxative containing Polyethylene Glycol 3350, the same active ingredient found in popular brands like MiraLAX. It works by drawing water into the bowel to soften stool and increase bowel movements, usually producing relief within 1 to 3 days. This makes it suitable for those dealing with occasional or severe constipation who need a gentle but effective option. The orange-flavored powder is easy to mix into any beverage, and it’s free from sugar, gluten, dyes, and grittiness, which can make it more pleasant to take. It’s designed for adults and kids 17 and older.

Since it is an osmotic laxative, it can be used safely for short-term relief; however, usage beyond a week should be under medical advice, especially for people with kidney problems or electrolyte imbalances. Side effects are generally mild but can include bloating or cramping. Polyethylene Glycol 3350 is widely recommended by doctors, which supports its reliability.

The onset of this product is slower compared to stimulant laxatives, so it may not be ideal if immediate relief is needed. It requires dissolving in liquid, which might be less convenient than tablets for some users. This product suits those seeking a doctor-trusted, gentle laxative option for managing severe constipation without harsh side effects.