10 Best Liver Supplement For Dogs 2025 in the United States

The Nutramax Laboratories Denamarin Liver Health Supplement for Large Dogs is a well-regarded product in the liver supplement category. It contains S-Adenosylmethionine (SAMe) and Silybin, which are known for their antioxidant properties and effectiveness in supporting liver health. SAMe helps increase levels of glutathione, an important detoxifying agent, while Silybin aids better absorption compared to other milk thistle extracts. The supplement comes in tablet form, flavored with liver, which can make it more palatable for dogs. The dosage is straightforward, targeting large dogs (over 35 lbs), with clear instructions to administer the tablets on an empty stomach for optimal absorption.

Nutramax Laboratories has a strong brand reputation, being a leader in pet health for over 30 years and backed by scientific formulations. The product is the #1 veterinarian recommended liver support supplement for dogs, adding an extra layer of credibility and trust. However, it is important to note that the product might be on the higher end of the price spectrum, which could be a drawback for some consumers. Additionally, while the flavoring is intended to make the supplement more appealing, some dogs might still resist taking tablets. This supplement is best suited for large breeds, making it less versatile for smaller dogs or other pets. It is a high-quality product with strong support from veterinarians, ideal for dog owners looking to improve their pet's liver health.

The SilymarinAdvanced Liver Health Supplement is designed specifically for large dogs and offers strong liver support with key ingredients like 425mg of SAMe and 35mg of Silybin from milk thistle. These components are known for aiding liver detoxification and repair, which can help dogs with liver illness or exposure to toxins. An added benefit is the supplement’s support for brain function, potentially keeping your dog's mind sharp as they age.

This product comes in tablet form, which can be given whole, split, or crushed and mixed with food, making dosage flexible and easy to manage. It contains no artificial colors, chemical coatings, gluten, or common fillers, contributing to its safety for your pet. Developed with input from veterinarians and nutrition experts, it inspires trust regarding its formulation and effectiveness.

It is specifically formulated for large breeds, so it may not be appropriate for smaller dogs without adjusting the dose or consulting a vet. The tablets should be used within six months after opening to maintain potency. If you’re looking for a natural, vet-designed liver supplement that also supports cognitive health in large dogs, this product represents a reliable option, provided you ensure proper dosing and consult your veterinarian to fit your dog’s unique health needs.

The Natural Dog Company Stinky Liver & Kidney Supplement Chews offer a comprehensive approach to supporting your dog’s liver and kidney health. The chews are formulated with a potent blend of ingredients like Milk Thistle, Curcumin, and Apple Cider Vinegar, known for their detoxifying properties. These ingredients are aimed at enhancing liver and kidney function, promoting toxin elimination, and balancing hydration. The product's strength lies in its easy-to-administer form, being chewable and requiring just a twice-yearly dosage, making it convenient for pet owners.

Vet-approved and made in the USA, the chews come with a strong backing of quality assurance, adding a layer of trust in their safety and effectiveness. However, the strong smell of the chews, though attractive to dogs, might be off-putting for some owners. Also, the product's benefits primarily target adult dogs, and it's not suitable for puppies under 12 weeks, pregnant/nursing dogs, or pets with existing conditions without prior vet consultation. Introducing it slowly to dogs with sensitive stomachs is recommended to avoid digestive upset.

These chews seem particularly beneficial for dogs requiring detox or those with minor kidney and liver concerns. Given the product's focus on natural ingredients and its supportive role in digestion and immunity, it could help in maintaining a healthier, more energetic pet. Still, it’s prudent for owners to consult their veterinarian, especially for dogs with pre-existing health issues, to ensure this supplement aligns with their pet's health needs.