10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

EcoVenger by EcoRaider is a natural spray designed to kill spiders and other household pests quickly. It uses plant-based active ingredients, making it a good choice for those wanting a safer alternative to harsh chemicals. One of its strengths is that it works not only on live insects but also on their eggs, which helps prevent future infestations.

The spray covers both indoor and outdoor areas like kitchens, garages, and patios, providing lasting protection for weeks. It is ready to use in a convenient 16 oz bottle and carries a pleasant mint scent. EcoVenger is child- and pet-safe, which makes it suitable for families and homes with animals.

While it promises long-lasting effects, the exact coverage area isn’t specified, so users might need multiple bottles for larger spaces. As a natural product, it may require more frequent applications compared to stronger chemical sprays, especially in heavy infestations. This product is ideal for those who prioritize safety and environmental friendliness over instant heavy-duty pest control. For those seeking a gentle, eco-friendly spider killer that also reduces the chance of eggs hatching, EcoVenger is worth considering.

Ortho BugClear Lawn Insect Killer is a granule-based insecticide designed to control a range of pests including spiders, ants, ticks, and fleas. It works by direct contact and treats a large area—up to 16,500 square feet—making it suitable for homeowners with medium to large lawns or garden spaces. The product provides up to six months of control against ants, which suggests it may also offer extended protection against spiders in treated areas. It is applied using a spreader and requires watering in afterward to activate the treatment.

Manufactured by a reputable company (Scotts), the product has a solid customer rating of 4.4 out of 5, indicating general satisfaction. It is intended for outdoor use only and targets multiple insects, so it may not be specialized solely for spiders. Users should follow instructions carefully to avoid harm to pets, beneficial insects, and the environment. This product offers a convenient and effective choice for those seeking broad pest control on lawns and gardens with good coverage and lasting effects, but proper application and environmental considerations are important.