10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

EcoVenger by EcoRaider is a natural spray designed to kill spiders and other household pests quickly. It uses plant-based active ingredients, making it a good choice for those wanting a safer alternative to harsh chemicals. One of its strengths is that it works not only on live insects but also on their eggs, which helps prevent future infestations.

The spray covers both indoor and outdoor areas like kitchens, garages, and patios, providing lasting protection for weeks. It is ready to use in a convenient 16 oz bottle and carries a pleasant mint scent. EcoVenger is child- and pet-safe, which makes it suitable for families and homes with animals.

While it promises long-lasting effects, the exact coverage area isn’t specified, so users might need multiple bottles for larger spaces. As a natural product, it may require more frequent applications compared to stronger chemical sprays, especially in heavy infestations. This product is ideal for those who prioritize safety and environmental friendliness over instant heavy-duty pest control. For those seeking a gentle, eco-friendly spider killer that also reduces the chance of eggs hatching, EcoVenger is worth considering.

The Hot Shot Ant, Roach and Spider Killer is a spray designed to kill a variety of insects including spiders, both indoors and outdoors. Its key strength is fast action—it kills insects on contact, making it effective for quick pest control. The formula dries quickly without leaving an oily or sticky residue, which means it won’t create a mess or unpleasant feel on treated surfaces. It's fragrance-free, so it won’t leave behind any strong or unwanted smells, which is beneficial for those sensitive to scents.

This product covers many common household and garden pests, not just spiders, giving it versatile use around the home. While it’s easy to use as a spray can, it is relatively heavy (over 16 pounds for the pack), which could be cumbersome if frequent movement is required. Users should exercise caution during application, keeping pets and children away.

This spray suits homeowners seeking a quick and general solution to spider and insect problems without strong smell or residue. However, those needing detailed safety information or long-lasting effects might want to consider additional options.