10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

EcoVenger by EcoRaider is a natural spray designed to kill spiders and other household pests quickly. It uses plant-based active ingredients, making it a good choice for those wanting a safer alternative to harsh chemicals. One of its strengths is that it works not only on live insects but also on their eggs, which helps prevent future infestations.

The spray covers both indoor and outdoor areas like kitchens, garages, and patios, providing lasting protection for weeks. It is ready to use in a convenient 16 oz bottle and carries a pleasant mint scent. EcoVenger is child- and pet-safe, which makes it suitable for families and homes with animals.

While it promises long-lasting effects, the exact coverage area isn’t specified, so users might need multiple bottles for larger spaces. As a natural product, it may require more frequent applications compared to stronger chemical sprays, especially in heavy infestations. This product is ideal for those who prioritize safety and environmental friendliness over instant heavy-duty pest control. For those seeking a gentle, eco-friendly spider killer that also reduces the chance of eggs hatching, EcoVenger is worth considering.

Miss Muffet's Revenge by Wet & Forget is a spider killer designed for both indoor and outdoor use. It features Bifenthrin as the active ingredient, which is effective against most spiders except Black Widow and Brown Recluse. One of its strongest points is its long-lasting residual effect, providing protection for up to 12 months with a single application. The attached sprayer is convenient, allowing you to spray up to 10 feet, which is great for those hard-to-reach areas.

Users have found it easy to apply, with the recommendation to use it in calm weather and allow it to dry completely for the best results. However, safety precautions should be taken to avoid entering treated areas before the spray is dry. The product has an unlimited shelf life and is ready to use straight out of the package, which adds to its convenience. On the downside, it is not suitable for eliminating Black Widow and Brown Recluse spiders, which could be a significant limitation for some users. Additionally, while it is effective, Bifenthrin is a chemical insecticide, which may raise environmental concerns for those looking for eco-friendly options.

If you need a reliable solution for most spider issues and ease of use is a priority, this product is a strong candidate.