10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

Miss Muffet's Revenge by Wet & Forget is a spider killer designed for both indoor and outdoor use. It features Bifenthrin as the active ingredient, which is effective against most spiders except Black Widow and Brown Recluse. One of its strongest points is its long-lasting residual effect, providing protection for up to 12 months with a single application. The attached sprayer is convenient, allowing you to spray up to 10 feet, which is great for those hard-to-reach areas.

Users have found it easy to apply, with the recommendation to use it in calm weather and allow it to dry completely for the best results. However, safety precautions should be taken to avoid entering treated areas before the spray is dry. The product has an unlimited shelf life and is ready to use straight out of the package, which adds to its convenience. On the downside, it is not suitable for eliminating Black Widow and Brown Recluse spiders, which could be a significant limitation for some users. Additionally, while it is effective, Bifenthrin is a chemical insecticide, which may raise environmental concerns for those looking for eco-friendly options.

If you need a reliable solution for most spider issues and ease of use is a priority, this product is a strong candidate.

Ortho BugClear Lawn Insect Killer is a granule-based insecticide designed to control a range of pests including spiders, ants, ticks, and fleas. It works by direct contact and treats a large area—up to 16,500 square feet—making it suitable for homeowners with medium to large lawns or garden spaces. The product provides up to six months of control against ants, which suggests it may also offer extended protection against spiders in treated areas. It is applied using a spreader and requires watering in afterward to activate the treatment.

Manufactured by a reputable company (Scotts), the product has a solid customer rating of 4.4 out of 5, indicating general satisfaction. It is intended for outdoor use only and targets multiple insects, so it may not be specialized solely for spiders. Users should follow instructions carefully to avoid harm to pets, beneficial insects, and the environment. This product offers a convenient and effective choice for those seeking broad pest control on lawns and gardens with good coverage and lasting effects, but proper application and environmental considerations are important.