10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

EcoVenger by EcoRaider is a natural spray designed to kill spiders and other household pests quickly. It uses plant-based active ingredients, making it a good choice for those wanting a safer alternative to harsh chemicals. One of its strengths is that it works not only on live insects but also on their eggs, which helps prevent future infestations.

The spray covers both indoor and outdoor areas like kitchens, garages, and patios, providing lasting protection for weeks. It is ready to use in a convenient 16 oz bottle and carries a pleasant mint scent. EcoVenger is child- and pet-safe, which makes it suitable for families and homes with animals.

While it promises long-lasting effects, the exact coverage area isn’t specified, so users might need multiple bottles for larger spaces. As a natural product, it may require more frequent applications compared to stronger chemical sprays, especially in heavy infestations. This product is ideal for those who prioritize safety and environmental friendliness over instant heavy-duty pest control. For those seeking a gentle, eco-friendly spider killer that also reduces the chance of eggs hatching, EcoVenger is worth considering.

The Hot Shot Ant, Roach & Spider Killer is a versatile insecticide spray designed for use both indoors and outdoors. It comes in a twin pack, which means you get two 17.5-ounce aerosol cans. One of its main strengths is its fast-acting formula that kills listed insects on contact, making it effective for immediate relief. However, it's important to note that while it effectively kills a variety of insects, its residual effect lasts up to 3 months only on non-porous surfaces and does not cover spiders, fleas, and certain types of ants such as carpenter, pharaoh, and fire ants. This could be a limitation if you're specifically targeting those pests.

The active ingredients, Imiprothrin and Lambda-Cyhalothrin, are commonly used in insecticides and are effective for rapid knockdown of insects. The spray is fairly easy to use, just point and spray, making it convenient for quick applications both inside your home and in your yard. Safety is always a concern with insecticides, and while the spray is effective, it should be used with caution around pets and children due to its chemical content.

As for environmental impact, like most chemical sprays, it’s not the most eco-friendly option and should be used sparingly to minimize any potential harm to beneficial insects and the surrounding environment. This product would be particularly beneficial for someone looking for an all-around insect killer for both indoor and outdoor use, but if your primary concern is spiders, you might want to consider options specifically targeted towards them.