10 Best Spider Killers 2026 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a variety of common household pests, including spiders, ants, cockroaches, and more. It comes in a 1.33-gallon spray container with a battery-powered wand, making it easier to apply the spray evenly indoors and along outdoor perimeters like foundations and patios. One of its standout features is the long-lasting barrier it creates, providing up to 12 months of protection against spiders and other insects on non-porous surfaces. This means you can use it as a preventative measure or after seeing pests, which adds flexibility to its use.

Because it controls several types of pests, it likely contains a strong insecticide, so users should follow safety instructions carefully, especially around pets and children. The size and weight of the container make it better suited for those who can handle a larger spray bottle, which may not be ideal for very small or delicate indoor spaces.

This insect killer offers broad coverage and a lengthy residual effect, making it a solid choice for homeowners looking to reduce spider problems along with other pests, as long as they are mindful of safe application and potential environmental effects.

The Ortho BugClear Insect Killer for Lawns & Landscapes Concentrate is a versatile insecticide that targets 235 types of bugs, including spiders, ants, ticks, mosquitoes, and fleas. This product stands out for its quick action, as it begins to kill insects within minutes and offers long-lasting control. This makes it highly effective for those who need immediate and durable pest management for their outdoor areas, including lawns, home perimeters, trees, and shrubs.

The concentrate form of the product requires mixing and must be applied with a separate sprayer like the Ortho Dial N' Spray or a tank sprayer, making it slightly less convenient for those looking for a ready-to-use solution. However, its flexibility in application methods can be seen as a benefit for those who already own spraying equipment.

Safety and environmental impact are important considerations, and while the product is effective, it does not specify being organic or eco-friendly, which may be a drawback for environmentally-conscious users. Additionally, it’s unscented and relatively lightweight, making it easy to handle during application. The product is best suited for those who need comprehensive, long-term bug control in medium to large outdoor areas and are comfortable with the mixing and application process.

The Hot Shot Ant, Roach and Spider Killer is a spray designed to kill a variety of insects including spiders, both indoors and outdoors. Its key strength is fast action—it kills insects on contact, making it effective for quick pest control. The formula dries quickly without leaving an oily or sticky residue, which means it won’t create a mess or unpleasant feel on treated surfaces. It's fragrance-free, so it won’t leave behind any strong or unwanted smells, which is beneficial for those sensitive to scents.

This product covers many common household and garden pests, not just spiders, giving it versatile use around the home. While it’s easy to use as a spray can, it is relatively heavy (over 16 pounds for the pack), which could be cumbersome if frequent movement is required. Users should exercise caution during application, keeping pets and children away.

This spray suits homeowners seeking a quick and general solution to spider and insect problems without strong smell or residue. However, those needing detailed safety information or long-lasting effects might want to consider additional options.