10 Best Spider Sprays 2025 in the United States

The Ortho Home Defense Insect Killer is designed to tackle a wide range of insects including spiders, making it a versatile choice for homeowners dealing with multiple pests. It comes in a large 1.33-gallon size and includes a battery-powered Comfort Wand, which makes spraying easier and more consistent, especially on indoor and outdoor surfaces. One major strength is its long-lasting protection, offering up to 12 months of residual effect on non-porous surfaces like floors and walls. This means fewer reapplications are needed, saving time and effort.

The spray can be used both indoors and on the perimeter of your home, providing flexible coverage around entry points like doors and windows. Safety-wise, while the product is made for home use and targets common pests, it’s important to follow label instructions carefully to avoid exposure to pets or children, as with most insecticides. The weight (over 12 pounds) and size might make handling a bit cumbersome for some users.

This product suits those seeking a reliable, broad-spectrum insect spray with long-lasting protection and ease of application, especially if you want to cover both indoor areas and home boundaries. If your main concern is spiders specifically, it performs solidly but also handles many other bugs, making it a good all-in-one option.

The Ortho Home Defense Max Indoor Insect Barrier is a comprehensive solution for dealing with common household insects, including spiders. One of its main strengths is its long-lasting protection, offering up to 12 months of control on non-porous surfaces. This is particularly beneficial for those who want a 'set it and forget it' solution. The inclusion of an Extended Reach Comfort Wand makes the application process much easier, especially for hard-to-reach areas, reducing the need for bending and minimizing hand fatigue. This is a notable advantage for ease of use compared to other products that require manual pumping.

Additionally, it dries faster than other Ortho formulas and does not leave stains or fumes, which enhances safety and convenience for households with children and pets. People and pets can re-enter treated areas once the spray has dried, adding an extra layer of safety. However, while the product is effective in covering a broad range of insects, the 1-gallon volume may not be sufficient for larger homes or extensive infestations, requiring multiple purchases. Some users might also find the nearly 9-pound weight a bit cumbersome to handle during application. There could be concerns about the odor, although the product claims to leave no fumes, individual sensitivity to chemical smells can vary.

This product is ideal for users looking for a long-lasting, easy-to-use indoor insect barrier with a focus on safety and convenience.

The Mighty Mint Peppermint Oil Spider Repellent Spray is a natural, plant-based option ideal for those who want to avoid harsh chemicals around pets and children. Its main active ingredient is concentrated peppermint oil, combined with geraniol, which effectively repels spiders, ants, and other common insects. You can use it both indoors and outdoors, making it flexible for spots like baseboards, patios, and entryways without worrying about surface stains.

The spray comes ready to use in a 16-ounce bottle, which makes application simple and targeted for quick treatments. One of its standout features is the fresh mint scent that leaves a pleasant, lingering aroma instead of strong chemical odors, which is great for scent-sensitive users. The spray works well as a repellent and contact killer, though it may require more frequent reapplication compared to stronger chemical alternatives due to limited long-term residual effects.

In terms of safety, the formula is pet-friendly and family-safe when used as directed, offering peace of mind in homes with kids and animals. This spray is an excellent choice if you prefer natural pest control and want an easy-to-use, fresh-smelling solution that handles common household bugs without toxic chemicals.