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Spot Creams

10 Best Spot Creams 2025 in the United States

Name: La Roche-Posay Mela B3 Serum, Dark Spot Corrector With Anti-Aging Melasyl + 10% Niacinamide, Discoloration Correcting Serum for Sun Spots, Age Spots & Post-Acne Marks, 30ML
Brand: La Roche-Posay
Price: 44.99 USD
Availability: InStock

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

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Winner

La Roche-Posay

La Roche-Posay Mela B3 Serum, Dark Spot Corrector With Anti-Aging Melasyl + 10% Niacinamide, Discoloration Correcting Serum for Sun Spots, Age Spots & Post-Acne Marks, 30ML

9.9

score

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Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

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La Roche-Posay

La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores

9.8

score

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Paula's Choice

Editor’s Choice

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

9.7

score

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Mario Badescu

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

9.5

score

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Paula's Choice

Paula's Choice BOOST 10% Azelaic Acid Booster Cream Gel, Licorice Extract & Salicylic Acid, Oil-Free Skin Brightening Serum, 1 Ounce

9.4

score

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Murad

Murad Rapid Dark Spot Correcting Serum – Skin Brightening Face Serum for Hyperpigmentation - Dark Spot Remover for Face - Glycolic Acid Treatment - Skin Care Backed by Science - 1 Fl Oz

9.1

score

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Proactiv

Proactiv Repair Acne Treatment Benzoyl Peroxide Spot Treatment and Repairing Serum Clear, 3 Fl Oz

8.9

score

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Murad

Murad Deep Relief Acne Treatment - Acne Control Max Strength 2% Salicylic Acid, Healing Treatment for Deep, Uncomfortable Acne, 1 Fl Oz

8.6

score

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Murad

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

8.4

score

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#10

Paula's Choice

Paula's Choice CLINICAL 1% Retinol Treatment Cream with Peptides, Vitamin C & Licorice Extract, Anti-Aging & Wrinkles, Travel Size. PACKAGING MAY VARY.

8.1

score

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10 Best Spot Creams 2025 in the United States

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

La Roche-Posay Mela B3 Serum, Dark Spot Corrector With Anti-Aging Melasyl + 10% Niacinamide, Discoloration Correcting Serum for Sun Spots, Age Spots & Post-Acne Marks, 30ML

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

Paula's Choice BOOST 10% Azelaic Acid Booster Cream Gel, Licorice Extract & Salicylic Acid, Oil-Free Skin Brightening Serum, 1 Ounce

Murad Rapid Dark Spot Correcting Serum – Skin Brightening Face Serum for Hyperpigmentation - Dark Spot Remover for Face - Glycolic Acid Treatment - Skin Care Backed by Science - 1 Fl Oz

Proactiv Repair Acne Treatment Benzoyl Peroxide Spot Treatment and Repairing Serum Clear, 3 Fl Oz

Murad Deep Relief Acne Treatment - Acne Control Max Strength 2% Salicylic Acid, Healing Treatment for Deep, Uncomfortable Acne, 1 Fl Oz

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

Paula's Choice CLINICAL 1% Retinol Treatment Cream with Peptides, Vitamin C & Licorice Extract, Anti-Aging & Wrinkles, Travel Size. PACKAGING MAY VARY.

FAQ

What are the best spot creams for acne?

What ingredients should I look for in a spot cream?

Are there any side effects of using spot creams?

What are the best spot creams for sensitive skin?

Do spot creams work for dark spots or hyperpigmentation?

10 Best Spot Creams 2025 in the United States

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

La Roche-Posay Mela B3 Serum, Dark Spot Corrector With Anti-Aging Melasyl + 10% Niacinamide, Discoloration Correcting Serum for Sun Spots, Age Spots & Post-Acne Marks, 30ML

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

Paula's Choice BOOST 10% Azelaic Acid Booster Cream Gel, Licorice Extract & Salicylic Acid, Oil-Free Skin Brightening Serum, 1 Ounce

Sea El Kelp Blemish Stick Skincare Pimple Blackhead & Acne Spot Treatment Witch Hazel Rosemary & Tea Tree Oil Serum & Skin Toner for Women & Men, All Skin Types - .33 oz

Paula's Choice CLINICAL 20% Niacinamide Vitamin B3 Concentrated Serum, Anti-Aging Treatment for Discoloration and Minimizing Large Pores, Fragrance-Free & Paraben-Free, 0.67 Ounce Dropper Bottle

Hylunia Beyond Complex Vitamin C Serum- 1.0 fl oz - Hyaluronic Acid, Zinc - Natural Vegan Skin Repair

PCA SKIN Anti Redness Remover Face Serum - Oil-Free Treatment Formulated with Advanced Calming Ingredients, Improves Irritation & Skin Tone (1 fl oz)

Farmaesthetics Complexion Conserve Remedy Reserve Serum 1 oz

Murad Rapid Dark Spot Correcting Serum – Skin Brightening Face Serum for Hyperpigmentation - Dark Spot Remover for Face - Glycolic Acid Treatment - Skin Care Backed by Science - 1 Fl Oz

Proactiv Repair Acne Treatment Benzoyl Peroxide Spot Treatment and Repairing Serum Clear, 3 Fl Oz

Murad Deep Relief Acne Treatment - Acne Control Max Strength 2% Salicylic Acid, Healing Treatment for Deep, Uncomfortable Acne, 1 Fl Oz

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

Paula's Choice CLINICAL 1% Retinol Treatment Cream with Peptides, Vitamin C & Licorice Extract, Anti-Aging & Wrinkles, Travel Size. PACKAGING MAY VARY.

FAQ

What are the best spot creams for acne?

What ingredients should I look for in a spot cream?

Are there any side effects of using spot creams?

What are the best spot creams for sensitive skin?

Do spot creams work for dark spots or hyperpigmentation?