10 Best Travel Backpacks 2025 in the United States

The MATEIN 45L Travel Backpack is a versatile and expandable travel companion suited for both men and women. With dimensions of 20x8.6x13.4 inches and a weight of just 2.16 pounds, it offers a large capacity while maintaining lightweight portability. Its expandable feature allows for additional packing space, making it suitable for weekend trips or occasional vacations. The backpack is designed to meet airline carry-on requirements, fitting easily in overhead compartments or under seats.

The convertible design, with hideaway padded shoulder straps, allows it to transform from a backpack to a briefcase, providing flexibility in carrying styles. The adjustable shoulder straps, air-mesh ventilated back panel, and sternum strap contribute to comfort during travel. Multiple compartments, including a front pocket for small items and internal compression straps, help in organizing belongings efficiently.

The use of water-resistant lightweight polyester ensures durability and weather resistance, while lockable zipper heads add a layer of security. The bag's accessibility is enhanced by the extra padded grab handles on the top and side. This travel backpack is highly practical for travelers seeking a large, lightweight, and versatile bag with excellent organizational features and solid weather resistance capabilities.

The Thule Aion Travel Backpack 40L is designed with travelers in mind, boasting a capacity of 40 liters, which is suitable for weekend trips or daily commutes. One of its standout features is the use of environmentally friendly materials, including 100% recycled polyester and a durable water-resistant coating, offering peace of mind during light rain. Weighing in at 1215 grams, it strikes a good balance between durability and portability.

The backpack excels in organization, thanks to multiple compartments, including a secure zippered top pocket for small items and padded storage for a laptop and tablet, making it ideal for tech-savvy travelers. The removable TPU rolltop bag is a clever addition, allowing for separation of items, which is great for keeping dirty clothes or shoes aside.

Comfort is addressed with adjustable straps, and the option to add a supporting hipbelt with the Thule Aion Sling Bag (sold separately) enhances fit during longer trips. In terms of security, the zippered pockets provide a reliable option for keeping valuables safe during travel. Accessibility is generally user-friendly, but the main compartment's rolltop style may require some getting used to for quick access.

The Timbuk2 Never Check Expandable Backpack offers a substantial 24.5-liter capacity, making it suitable for those needing ample space while traveling. Despite its large capacity, it remains compact enough to fit in small spaces, which is a significant advantage for air travel. The backpack weighs 1.2 kilograms (2.64 pounds), which is relatively moderate for its size and features, making it manageable for most users.

Constructed from durable 420x2000D Cordura material, it promises longevity and robustness, essential for frequent travelers. The backpack's organization capabilities are impressive, featuring a padded laptop compartment for up to 15-inch laptops, multiple internal and external pockets for various items, and an expandable water bottle pocket. This makes it easy to keep belongings sorted and accessible. Comfort is a priority with padded shoulder straps and a back panel, along with an adjustable sternum strap for better weight distribution. However, its suitability for prolonged use might depend on individual comfort preferences.

Security features include side hooks to protect pocket openings and weatherproof zippers, adding a layer of protection against theft and the elements. The backpack's accessibility is enhanced by top and side padded handles, offering multiple carrying options. The weather resistance is adequate, thanks to the weatherproof zippers, though the material's overall performance in extreme weather conditions isn't specified. The lifetime warranty from Timbuk2 is a standout feature, assuring users of the product's quality and durability. In summary, the Timbuk2 Never Check Expandable Backpack is a well-rounded option for travelers seeking durability, organization, and comfort, though it might not be the top choice for everyone depending on specific needs and preferences.