10 Best Vertical Mouses 2025 in the United States

The ASOYIOL Ergonomic Mouse Wireless is designed for users who need a comfortable and strain-free experience. Its vertical ergonomic design is beneficial for reducing hand strain and promoting healthier hand positioning, making it a good option for daily computer use and gaming. With adjustable DPI settings of 1000, 1200, and 1600, it allows for precise tracking on various surfaces, which is useful for both regular tasks and gaming.

The mouse features six buttons, including 'Page Back' and 'Page Forward' functionalities, catering to users who need extra buttons for navigation or gaming purposes. Connectivity is straightforward using a USB receiver, though it doesn't support MacOS X, limiting its compatibility to Windows and Linux systems. The built-in rechargeable battery is convenient and includes a power-saving mode after 8 minutes of inactivity, enhancing battery life.

The mouse is lightweight and portable, weighing only 3.35 ounces. If you're looking for an ergonomic mouse for Windows or Linux systems, this model is a solid choice, although Mac users will need to look elsewhere.

The Evoluent Vertical Mouse D Large (VMDL) is tailored for users seeking ergonomic solutions to minimize wrist strain, particularly beneficial for those working long hours at a computer. Its vertical design encourages a natural hand position, potentially reducing the risk of repetitive stress injuries. The unique grooved buttons offer a secure grip, enhancing control, which can be a comfort for users accustomed to traditional mouses.

One of the VMDL's standout features is its Smart Scrolling capability, allowing a fluid transition from precise to rapid scrolling, adapting to your pace. While it boasts programmable buttons and an integrated volume control, customization options may appeal to users who enjoy personalized setups for efficiency. As a wired mouse, it guarantees uninterrupted connectivity, but it lacks the flexibility of wireless options for those who prefer a clutter-free workspace.

Compatibility is broad, supporting both Windows and Mac systems, making it versatile for diverse computer users. However, while it functions without drivers, installing them unlocks advanced features, potentially adding complexity for less tech-savvy users. Despite its ergonomic appeal, the lack of DPI adjustment could be a downside for gamers or graphic designers who require precise sensitivity control. Also, as a wired device, it's not constrained by battery life, but the trade-off is tethered movement, which might not suit everyone.

Finally, the inclusion of a Jestik Microfiber Cloth is a thoughtful touch, helping maintain the mouse's cleanliness and longevity. With positive customer reviews and a notable ranking among computer mice, the Evoluent Vertical Mouse D Large presents itself as a solid choice for those prioritizing ergonomic design and consistent performance in a desktop setting.

The J-Tech Digital Wired Ergonomic Vertical USB Mouse is designed with a focus on comfort and reducing strain, making it a good choice for users with carpal tunnel syndrome or those who spend long hours on the computer. Its ergonomic 'handshake' design is effective in minimizing wrist and arm stress, and the removable palm rest adds to the comfort level.

The mouse offers adjustable DPI settings (600/1000/1600), allowing users to customize the sensitivity based on their preference and tasks, which is a useful feature for both everyday use and light gaming or graphic work. Connectivity is straightforward with a USB connection, ensuring compatibility with most computers without the need for additional drivers. However, being wired may limit some users who prefer the freedom of a wireless setup.

The back/forward thumb buttons add convenience for web browsing and other repetitive tasks, and these buttons can be customized with third-party software for enhanced functionality. One notable downside is the need for a lithium-ion battery, even though it's rechargeable, which means you'll need to remember to keep it charged. In terms of compatibility, it works well with both Windows and Mac systems, making it a versatile option. Despite a few drawbacks, such as being wired and the need for charging, the J-Tech Digital V628 stands out for its ergonomic design and customization options.