10 Best Bed Bug Killer Sprays 2026 in the United States

The Ortho Home Defense Max Bed Bug Killer spray is designed to handle tough bed bugs, including those resistant to common chemicals, as well as their eggs. It also targets other pests like fleas and ticks, making it a versatile choice for home pest control. One of its strong points is the lasting protection it offers—up to 16 weeks on hard surfaces like ceramic—so you won’t need to reapply frequently in those areas. The spray is unscented, which is a plus if you prefer products without strong chemical odors. It's intended for spot treatment, which means you spray it around beds, floors, and other problem spots rather than widespread application, helping limit exposure.

For best results, it is often used in combination with other Ortho products like their bed bug trap and powder to provide a comprehensive pest control approach. Safety-wise, while it’s effective, it still requires careful application, especially around pets and children, as with most chemical sprays. This product is suitable if you need a targeted, residual bed bug spray that works on resistant bugs and prefer an odor-free option.

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand is a robust solution for tackling bed bugs, including pyrethroid-resistant varieties, as well as fleas and ticks. The spray is designed for indoor use, particularly around bed frames, baseboards, and mattress seams, making it suitable for targeted treatments in areas where pests commonly hide. The Comfort Wand feature aids in reaching tight and difficult spots, enhancing the application process.

This product is part of a comprehensive system, suggesting that using it in conjunction with other Ortho products may yield optimal results. The active ingredients are potent, ensuring efficacy in eliminating pests, including their eggs, which is crucial for preventing reinfestation. Safety is a consideration, as it is intended for indoor use; however, users should follow instructions carefully to avoid exposure to chemicals.

The residual effect helps in maintaining a pest-free environment for a period after application. While the scent is labeled as 'Tick,' it may still be noticeable and potentially unpleasant for some users. Its weight and size might make handling slightly cumbersome. The product ranks well in its category, suggesting it is a popular choice among consumers looking for indoor pest control solutions.

The Premo Plus+ Bed Bug Spray Extra Strength is a natural bed bug killer that promises quick effectiveness without harmful chemicals. It uses natural ingredients and is safe for use around children and pets, making it a good choice for families. The spray is both stain and scent-free, which is advantageous for maintaining cleanliness and avoiding unpleasant odors in your living spaces.

This spray can be used on various surfaces, including bedding, furniture, and carpets, providing versatile application options. It is designed to kill bed bugs at all life stages, ensuring thorough treatment. However, users should follow the application instructions carefully to ensure no staining occurs, even though the product claims otherwise.

The large 128 oz volume is suitable for extensive use, which might be beneficial for larger homes or frequent usage. It is effective, but some users might find the need for repeated applications to fully eradicate bed bugs. This product is a robust option for those seeking a natural and safe bed bug treatment, especially in households with children and pets.