10 Best Bed Bugs Sprays 2025 in the United States

The Hot Shot Bedbug & Flea Fogger is designed to tackle bed bugs, fleas, and other common household pests like lice and ticks. It contains an active ingredient called Nylar, which not only kills existing fleas but also helps prevent new ones from maturing into biting adults, providing a residual effect that may last up to 7 months. This makes it a strong choice if you want longer-term control rather than just a quick fix. It's EPA-approved and intended for use indoors in enclosed spaces such as bedrooms, basements, and pet areas, which means it's suitable for many home environments. Each can covers up to 2,000 cubic feet, so depending on your space size, several cans might be necessary.

In terms of safety, since it is an aerosol fogger, you’ll need to follow instructions carefully to avoid exposure during use and ensure proper ventilation afterward. Applying the fogger is relatively easy, but you must prepare the area by covering food and removing people and pets temporarily.

Customers have rated it positively, indicating good effectiveness for bed bugs and fleas, especially with repeated or follow-up treatments. However, like many foggers, it may not reach all hiding spots perfectly, so combining it with other cleaning or treatment methods might be necessary for severe infestations. This fogger is suitable for those looking for a convenient, indoor pest control solution that offers both immediate and extended protection against bed bugs and fleas.

The Ortho Home Defense Max Bed Bug Killer is a strong choice for tackling bed bugs, including those resistant to common chemicals. Its active ingredients effectively kill bed bugs and their eggs, as well as fleas and ticks, making it useful against multiple pests. A big plus is its long-lasting effect, continuing to kill bugs for up to 16 weeks on hard surfaces like ceramic, which helps prevent re-infestation.

The spray is designed for spot treatment around beds, floors, and furniture, which is convenient for targeted use without widespread application. It comes unscented, so it won’t leave an unpleasant smell in your home—a nice feature for sensitive users. Customers generally rate it well, praising its effectiveness and ease of use. The residual effect mainly works on non-porous surfaces, so results might not last as long on carpets or fabrics.

While it promises safety, users should still follow instructions carefully to avoid exposure, as with any pesticide. For those seeking a product that kills quickly and provides weeks of protection on hard surfaces, this spray fits the bill, especially when combined with Ortho’s other bed bug products for detection and powder treatment.

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is designed to tackle stubborn bed bugs, including those resistant to common treatments, as well as their eggs, fleas, and ticks. A key strength is its Comfort Wand, which makes the spray easy to apply, especially in hard-to-reach spots around bed frames and baseboards, contributing to its ease of use. The product is part of a comprehensive 3-step solution, which may appeal to those seeking a systematic approach to pest control. Additionally, with a sizable 1-gallon volume, it offers substantial coverage.

In terms of safety, like many pest control products, it is important to exercise caution and follow label instructions carefully to minimize any potential risks. The spray is labeled for indoor use, but users sensitive to chemical odors should note its 'Tick' scent. While not overwhelmingly strong based on user feedback, it is present, which could be a downside for those preferring odorless solutions.

The spray is effective, particularly in combating pyrethroid-resistant bed bugs, a challenging pest. However, achieving optimal results often requires its use in conjunction with the other steps in the Ortho Bed Bug Solution System. This might be seen as a drawback for those looking for a standalone solution.