10 Best Cat Urine Enzymatic Cleaner 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a strong contender in the category of enzymatic cleaners for cat urine and other pet-related stains. Its enzyme formula is key to its effectiveness, as it works by breaking down odors and stains at a deep level, ensuring a thorough clean. This makes it particularly suitable for pet owners looking to tackle strong odors from urine, feces, or even vomit without harsh chemicals. One of its biggest advantages is that it's certified safe for use around pets and children, being chlorine-free and color-safe, which provides peace of mind when cleaning in family spaces.

Compatibility with various surfaces is another strong point; it can be used on carpets, floors, furniture, and other pet areas. This versatility is beneficial for pet owners who need a reliable cleaner for multiple surfaces. Additionally, the product is eco-friendly, appealing to those looking to minimize their environmental impact.

While the product has a lot of strengths, there are a few considerations. Some users may find that the drying time can vary, and while it's designed to eliminate both stains and odors, results can depend on the severity of the stain or the material being cleaned. Moreover, there are mixed experiences regarding its effectiveness on older, set-in stains, which may not be as easily resolved. Lastly, while the scent is described as 'original', some users may prefer a more fragrant option or find the scent not to their liking.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is a strong contender for anyone needing a versatile cleaner that handles tough organic stains and odors, including cat urine. Its enzyme formula uses probiotics that actively break down proteins, fats, and other organic matter for up to 21 days, which means it keeps working long after you apply it. This is particularly useful for stubborn pet stains that can hide in carpets or grout. The cleaner is safe on a variety of surfaces like floors, carpets, bathroom and kitchen areas, making it a flexible option for different household messes. It comes with a fresh lemon and sage scent that helps mask odors without being overpowering. Application is straightforward—you just spray and let it work, with no need for scrubbing.

Being biobased and free from harsh chemicals makes it an eco-friendly choice for pet owners looking for safer cleaning solutions. On the downside, because it’s a multipurpose cleaner, it might not be as specialized for cat urine as some dedicated enzymatic pet stain removers, which sometimes include additional stain-lifting agents. Also, the larger 1-gallon size is great for extensive use but might be bulky or more than needed for small households.

This cleaner offers a plant-based, probiotic-powered way to tackle pet odors and stains effectively across many surfaces, with the added benefit of a natural scent and lasting action.

The Simple Solution Extreme Pet Stain and Odor Remover is designed for pet owners dealing with stubborn stains and odors, particularly from cats and dogs. One of its major strengths is its potent enzyme formula, which is three times stronger than regular cleaners, making it highly effective for deep cleaning tough messes. Users appreciate how it works on various surfaces, including carpets, upholstery, and fabric toys, ensuring a versatile solution for different cleaning needs. Its eco-friendly aspect also stands out, as it’s safe around children and pets when applied correctly, allowing for peace of mind during use.

The application method is straightforward—just saturate the area, wait a few minutes for the enzymes to work, and then blot it dry. This user-friendly approach makes it accessible even for those who might not be particularly tech-savvy or experienced with cleaning products. Additionally, the product is made in the USA, which can be a positive aspect for consumers looking to support local manufacturing.

This product is a strong choice for pet owners seeking a reliable enzymatic cleaner for tough stains and odors, but it may require a bit of patience regarding drying time and surface testing.