10 Best Cat Urine Enzymatic Cleaner 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a strong contender in the category of enzymatic cleaners for cat urine and other pet-related stains. Its enzyme formula is key to its effectiveness, as it works by breaking down odors and stains at a deep level, ensuring a thorough clean. This makes it particularly suitable for pet owners looking to tackle strong odors from urine, feces, or even vomit without harsh chemicals. One of its biggest advantages is that it's certified safe for use around pets and children, being chlorine-free and color-safe, which provides peace of mind when cleaning in family spaces.

Compatibility with various surfaces is another strong point; it can be used on carpets, floors, furniture, and other pet areas. This versatility is beneficial for pet owners who need a reliable cleaner for multiple surfaces. Additionally, the product is eco-friendly, appealing to those looking to minimize their environmental impact.

While the product has a lot of strengths, there are a few considerations. Some users may find that the drying time can vary, and while it's designed to eliminate both stains and odors, results can depend on the severity of the stain or the material being cleaned. Moreover, there are mixed experiences regarding its effectiveness on older, set-in stains, which may not be as easily resolved. Lastly, while the scent is described as 'original', some users may prefer a more fragrant option or find the scent not to their liking.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is a strong contender for anyone needing a versatile cleaner that handles tough organic stains and odors, including cat urine. Its enzyme formula uses probiotics that actively break down proteins, fats, and other organic matter for up to 21 days, which means it keeps working long after you apply it. This is particularly useful for stubborn pet stains that can hide in carpets or grout. The cleaner is safe on a variety of surfaces like floors, carpets, bathroom and kitchen areas, making it a flexible option for different household messes. It comes with a fresh lemon and sage scent that helps mask odors without being overpowering. Application is straightforward—you just spray and let it work, with no need for scrubbing.

Being biobased and free from harsh chemicals makes it an eco-friendly choice for pet owners looking for safer cleaning solutions. On the downside, because it’s a multipurpose cleaner, it might not be as specialized for cat urine as some dedicated enzymatic pet stain removers, which sometimes include additional stain-lifting agents. Also, the larger 1-gallon size is great for extensive use but might be bulky or more than needed for small households.

This cleaner offers a plant-based, probiotic-powered way to tackle pet odors and stains effectively across many surfaces, with the added benefit of a natural scent and lasting action.

The Angry Orange Stain Remover is a dual-action enzyme cleaner designed to eliminate pet odors and stains, including those from cat urine. It uses a powerful enzyme formula that tackles smells and stains at their source, ensuring long-lasting freshness for up to 80 hours. This product is versatile and can be used on a variety of surfaces such as carpets, hardwood floors, and fabrics.

One of its standout features is the citrus scent derived from cold-pressed orange oils, which leaves a pleasant fruity fragrance that is safe for pets and children, although it should not be sprayed directly on them. The spray application method makes it easy to use, and it comes in a convenient 32oz bottle.

This product is well-suited for pet owners dealing with frequent stains and odors who appreciate a pleasant scent and multi-surface compatibility.