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10 Best Cat Urine Enzymatic Cleaner 2025 in the United States

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Our Top Picks

#1

Winner

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Rating
10.0
Chosen by1,474
Enzyme Formula
Surface Compatibility
Scent

Most important from
123704 reviews

Enzyme Formula
Completely eliminates urine odors and stains, leaving no trace even under black light.
Surface Compatibility
Highly effective on a variety of surfaces including carpets, couches, stainless steel, laminate, and wood trims.
Scent
The scent is mild and pleasant, significantly better than the offensive odors of the stains themselves.
Application Method
Requires generous application and patience, often needing multiple treatments and a few hours of drying time for best results.
Drying Time
Requires generous application and patience, often needing multiple treatments and a few hours of drying time for best results.
Eco-Friendliness
Users recommend wearing a respiratory mask during application due to potential irritation like dry mouth and sensitive gums.

The Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a powerful enzymatic cleaner designed to tackle tough pet stains and odors, especially cat and dog urine. Its enzyme formula breaks down organic stains and smells thoroughly, making it effective for carpets, floors, furniture, clothing, and even pet carriers. It’s certified safe by the Carpet and Rug Institute, chlorine-free, and has no harmful chemicals, so it’s gentle around pets and kids. The scent is labeled as “original,” meaning it is mild and not overpowering.

This cleaner is easy to use in liquid drop form and comes in a large 1-gallon size, which is convenient for multiple or heavy uses. Using an absorbent towel to remove stains first can help speed up the drying process. The product is eco-friendly with natural and organic ingredients, making it a good option for those who want a chemical-free solution. Its weight and size might be bulky for some to handle.

Customer reviews are generally positive, reflecting confidence in its stain and odor removal abilities. This cleaner is a suitable choice for pet owners seeking a safe, effective, and versatile enzyme cleaner for a variety of surfaces around the home.

Rating
10.0
Chosen by1,474
Enzyme Formula
Surface Compatibility
Scent

Most important from
123704 reviews

Enzyme Formula
Completely eliminates urine odors and stains, leaving no trace even under black light.
Surface Compatibility
Highly effective on a variety of surfaces including carpets, couches, stainless steel, laminate, and wood trims.
Scent
The scent is mild and pleasant, significantly better than the offensive odors of the stains themselves.
Application Method
Requires generous application and patience, often needing multiple treatments and a few hours of drying time for best results.
Drying Time
Requires generous application and patience, often needing multiple treatments and a few hours of drying time for best results.
Eco-Friendliness
Users recommend wearing a respiratory mask during application due to potential irritation like dry mouth and sensitive gums.
#2

Angry Orange Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 1 Gallon

Rating
9.1
Enzyme Formula
Surface Compatibility
Scent

Most important from
127751 reviews

Enzyme Formula
Effectively eliminates strong cat urine odors with results that last and never return.
Surface Compatibility
Ideal for hard, sealed surfaces but users should test on delicate fabrics or carpets before use.
Scent
Leaves a fresh, natural citrus scent that receives compliments from visitors.
Application Method
A little product goes a long way; it cleans thoroughly without needing to soak the area.

Angry Orange Pet Odor Eliminator is a strong cleaner designed to tackle tough pet odors, especially from dog and cat urine. It uses natural orange oil instead of harsh chemical smells, leaving a fresh citrus scent that many pet owners find pleasant. This cleaner works well on hard and sealed surfaces, like floors, where pet messes usually occur. It comes as a large 1-gallon spray bottle, making it convenient for frequent or heavy use. One of its strengths is that it avoids parabens, sulfates, and phthalates, which makes it safer for homes with pets when directions are followed.

It is important to note that Angry Orange is not specifically advertised as an enzymatic cleaner, which means it relies more on natural oils and cleaning agents rather than enzymes that break down urine proteins. This could affect its effectiveness on older or deeply set urine stains compared to some enzymatic products. The drying time is typical for spray cleaners and should not be overly long, but it’s advised to allow the treated area to air dry fully. Also, while it is made in the USA and has a reputation for quality, it may not be the best option for all surface types beyond hard, sealed floors, so testing on delicate fabrics or carpets is recommended.

This product represents a solid choice for pet owners looking for a natural-smelling, powerful odor remover mainly for floors and hard surfaces, although those seeking a pure enzymatic action specifically for cat urine might want to consider other specialized formulas.

Rating
9.1
Enzyme Formula
Surface Compatibility
Scent

Most important from
127751 reviews

Enzyme Formula
Effectively eliminates strong cat urine odors with results that last and never return.
Surface Compatibility
Ideal for hard, sealed surfaces but users should test on delicate fabrics or carpets before use.
Scent
Leaves a fresh, natural citrus scent that receives compliments from visitors.
Application Method
A little product goes a long way; it cleans thoroughly without needing to soak the area.
#3

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Rating
8.5
Enzyme Formula
Surface Compatibility
Scent

Most important from
123704 reviews

Enzyme Formula
The smell was gone, and the few stains that were there - poof - GONE!
Surface Compatibility
It can be used on literally ANYTHING that has a smell, and it will fight against whatever the smell is and whatever that smell has left behind to make that smell, as if it was never there to begin with after you spray this cleaner on whatever it is!
Scent
The product is truly not so bad. It does have a minty smell, but it’s not really too strong and much more pleasant than the overpowering, once invincible foe that is cat urine.
Application Method
I threw a bunch of clothes in the tub, tossed a liberal amount in with warm water, and let their grimy, oily, cat urine selves hang out awhile. Miraculously ammonia-free clean stuff.

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a strong contender in the category of enzymatic cleaners for cat urine and other pet-related stains. Its enzyme formula is key to its effectiveness, as it works by breaking down odors and stains at a deep level, ensuring a thorough clean. This makes it particularly suitable for pet owners looking to tackle strong odors from urine, feces, or even vomit without harsh chemicals. One of its biggest advantages is that it's certified safe for use around pets and children, being chlorine-free and color-safe, which provides peace of mind when cleaning in family spaces.

Compatibility with various surfaces is another strong point; it can be used on carpets, floors, furniture, and other pet areas. This versatility is beneficial for pet owners who need a reliable cleaner for multiple surfaces. Additionally, the product is eco-friendly, appealing to those looking to minimize their environmental impact.

While the product has a lot of strengths, there are a few considerations. Some users may find that the drying time can vary, and while it's designed to eliminate both stains and odors, results can depend on the severity of the stain or the material being cleaned. Moreover, there are mixed experiences regarding its effectiveness on older, set-in stains, which may not be as easily resolved. Lastly, while the scent is described as 'original', some users may prefer a more fragrant option or find the scent not to their liking.

Rating
8.5
Enzyme Formula
Surface Compatibility
Scent

Most important from
123704 reviews

Enzyme Formula
The smell was gone, and the few stains that were there - poof - GONE!
Surface Compatibility
It can be used on literally ANYTHING that has a smell, and it will fight against whatever the smell is and whatever that smell has left behind to make that smell, as if it was never there to begin with after you spray this cleaner on whatever it is!
Scent
The product is truly not so bad. It does have a minty smell, but it’s not really too strong and much more pleasant than the overpowering, once invincible foe that is cat urine.
Application Method
I threw a bunch of clothes in the tub, tossed a liberal amount in with warm water, and let their grimy, oily, cat urine selves hang out awhile. Miraculously ammonia-free clean stuff.

Buying Guide for the Best Cat Urine Enzymatic Cleaner

Choosing the right cat urine enzymatic cleaner is essential for effectively removing stains and odors caused by cat urine. Enzymatic cleaners work by breaking down the proteins in urine, which helps to eliminate the smell and prevent your cat from returning to the same spot. When selecting a cleaner, it's important to consider several key specifications to ensure you get the best product for your needs.
Enzyme FormulaThe enzyme formula is the core component of an enzymatic cleaner. It contains specific enzymes that break down the proteins in cat urine, effectively removing the odor and stain. A strong enzyme formula is crucial for thorough cleaning. Look for products that specifically mention they target cat urine, as these will have the right enzymes for the job. If you have multiple pets or persistent stains, opt for a cleaner with a more concentrated enzyme formula.
Surface CompatibilitySurface compatibility refers to the types of surfaces the cleaner can be used on, such as carpets, upholstery, hardwood floors, and tiles. It's important to choose a cleaner that is safe for the surfaces you need to treat. Some cleaners are versatile and can be used on multiple surfaces, while others are designed for specific materials. If you need to clean various surfaces, a multi-surface cleaner is a good choice. Always check the label to ensure the cleaner won't damage your floors or furniture.
ScentThe scent of the cleaner can affect your overall experience. Some enzymatic cleaners have a strong fragrance to mask the odor of urine, while others are unscented or have a mild scent. If you or your pets are sensitive to strong smells, an unscented or lightly scented cleaner may be preferable. On the other hand, if you want to leave a fresh scent behind, choose a cleaner with a fragrance you find pleasant. Consider your personal preference and any sensitivities when selecting the scent.
Application MethodThe application method refers to how the cleaner is applied to the affected area. Common methods include spray bottles, pour bottles, and foam applicators. Spray bottles are convenient for spot cleaning and small areas, while pour bottles are useful for larger stains. Foam applicators can help the cleaner penetrate deeper into carpets and upholstery. Choose an application method that suits the size and type of the stains you need to treat. For ease of use, a spray bottle is often the most versatile option.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This can vary depending on the product and the surface being treated. Faster drying times are more convenient, especially if you need to use the area soon after cleaning. However, some cleaners may require a longer drying time to ensure the enzymes fully break down the urine proteins. Consider how quickly you need the area to be usable again and choose a cleaner with an appropriate drying time for your needs.
Eco-FriendlinessEco-friendliness refers to the environmental impact of the cleaner. Eco-friendly enzymatic cleaners are made with biodegradable ingredients and are free from harsh chemicals that can harm the environment. If you are environmentally conscious, look for products labeled as eco-friendly or biodegradable. These cleaners are safer for the environment and often safer for your pets and family as well. Choosing an eco-friendly cleaner can help reduce your environmental footprint while effectively cleaning up cat urine.

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