10 Best Enzymatic Cleaner 2025 in the United States

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a well-regarded enzymatic cleaner designed specifically for pet-related stains and odors, such as urine, feces, and vomit. It uses pet-safe enzymes that effectively break down organic stains and odors on a variety of surfaces including carpets, floors, furniture, clothing, and pet areas. This one-gallon spray is concentrated enough for repeated use, making it suitable for homes with multiple pets or frequent messes.

The product is chlorine-free, color safe, and certified by the Carpet and Rug Institute, ensuring it won't damage carpets or leave harmful residues. Its original scent is mild and not overpowering, so it freshens without masking odors with strong fragrances. Application is simple—just spray, let it work, and blot clean. An important strength is its eco-friendly formulation, free from harsh chemicals, making it safe around pets and children, which is crucial for home use.

On the downside, while it is effective on many surfaces, it may require multiple treatments on older or very stubborn stains. Also, it’s somewhat heavy and bulky due to the large 1-gallon size, which might be less convenient for occasional users or those with limited storage. Rocco & Roxie’s enzymatic cleaner is a reliable, pet-safe option for pet owners needing a strong yet gentle solution for organic stains and odors across multiple surfaces.

The Rocco & Roxie Extreme Stain & Odor Eliminator is a strong enzymatic cleaner designed specifically to tackle tough pet-related stains and odors like urine, vomit, and feces. It uses a bio-enzymatic formula combined with mineral-based odor neutralizers to break down organic matter deeply, which is effective for stubborn smells, especially from pets. The cleaner is versatile, working well on a wide range of surfaces such as carpets, furniture, clothing, pet bedding, and even vehicles, making it ideal for pet owners dealing with accidents indoors and on the go. Its light Meyer lemon scent is subtle and fades quickly, which is a plus if you prefer a fresher yet not overpowering smell.

Application is straightforward with a spray bottle format, allowing targeted use without mess. Importantly, it is non-toxic, chlorine-free, and safe for use around children and pets when used as directed, and it holds the Carpet and Rug Institute’s Seal of Approval for safety on carpets. On the downside, while it is highly rated by users, it is primarily geared toward pet stains, so it might be less effective on non-organic or chemical-based stains. Also, it is a liquid formulation, so it needs to be stored carefully to avoid spills.

For eco-conscious buyers, while it is non-toxic and free of harsh propellants, the description does not specify if it is biodegradable or uses sustainably sourced ingredients. This enzymatic cleaner is best suited for pet owners seeking a reliable, safe, and easy-to-use solution for removing tough organic stains and odors from various household surfaces.

Angry Orange Pet Odor Eliminator is a strong enzymatic cleaner specially designed to tackle tough pet odors like dog and cat urine, feces, and vomit. It uses natural orange oil to not only clean but also leave a fresh citrus scent behind, avoiding the harsh chemical smells some cleaners have. This product works well on hard and sealed surfaces such as floors and carpets, making it versatile for common pet mess areas. The gallon size is convenient for refills and frequent use.

It is safe for homes with pets since it doesn't contain harmful chemicals like parabens or sulfates, which adds peace of mind for pet owners. While it cleans effectively, it's mainly suited for hard surfaces rather than delicate fabrics or upholstery. The application is straightforward, but since it’s a concentrated gallon, some users might prefer smaller sizes for easier handling.

Angry Orange is a reliable choice if you want a powerful, citrus-scented odor eliminator for hard surfaces that is safe around pets and free from strong chemical odors.