10 Best Enzymatic Cleaner 2025 in the United States

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a well-regarded enzymatic cleaner designed specifically for pet-related stains and odors, such as urine, feces, and vomit. It uses pet-safe enzymes that effectively break down organic stains and odors on a variety of surfaces including carpets, floors, furniture, clothing, and pet areas. This one-gallon spray is concentrated enough for repeated use, making it suitable for homes with multiple pets or frequent messes.

The product is chlorine-free, color safe, and certified by the Carpet and Rug Institute, ensuring it won't damage carpets or leave harmful residues. Its original scent is mild and not overpowering, so it freshens without masking odors with strong fragrances. Application is simple—just spray, let it work, and blot clean. An important strength is its eco-friendly formulation, free from harsh chemicals, making it safe around pets and children, which is crucial for home use.

On the downside, while it is effective on many surfaces, it may require multiple treatments on older or very stubborn stains. Also, it’s somewhat heavy and bulky due to the large 1-gallon size, which might be less convenient for occasional users or those with limited storage. Rocco & Roxie’s enzymatic cleaner is a reliable, pet-safe option for pet owners needing a strong yet gentle solution for organic stains and odors across multiple surfaces.

The Rocco & Roxie Extreme Stain & Odor Eliminator is a strong enzymatic cleaner designed specifically to tackle tough pet-related stains and odors like urine, vomit, and feces. It uses a bio-enzymatic formula combined with mineral-based odor neutralizers to break down organic matter deeply, which is effective for stubborn smells, especially from pets. The cleaner is versatile, working well on a wide range of surfaces such as carpets, furniture, clothing, pet bedding, and even vehicles, making it ideal for pet owners dealing with accidents indoors and on the go. Its light Meyer lemon scent is subtle and fades quickly, which is a plus if you prefer a fresher yet not overpowering smell.

Application is straightforward with a spray bottle format, allowing targeted use without mess. Importantly, it is non-toxic, chlorine-free, and safe for use around children and pets when used as directed, and it holds the Carpet and Rug Institute’s Seal of Approval for safety on carpets. On the downside, while it is highly rated by users, it is primarily geared toward pet stains, so it might be less effective on non-organic or chemical-based stains. Also, it is a liquid formulation, so it needs to be stored carefully to avoid spills.

For eco-conscious buyers, while it is non-toxic and free of harsh propellants, the description does not specify if it is biodegradable or uses sustainably sourced ingredients. This enzymatic cleaner is best suited for pet owners seeking a reliable, safe, and easy-to-use solution for removing tough organic stains and odors from various household surfaces.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is a versatile and powerful option for those looking to tackle organic stains and odors on various surfaces. It uses a special blend of enzyme-producing probiotics that break down proteins, fats, and oils naturally, which helps clean deeply even in hard-to-reach areas like grout or drains. This enzymatic action continues working for up to 21 days, offering prolonged cleaning beyond the initial application.

It's safe for multiple surfaces including floors, carpets, bathroom and kitchen areas, and trash bins, making it a convenient all-in-one product. The cleaner also eliminates odors at their source, such as pet urine or food waste, rather than just masking them, and it leaves behind a fresh but mild lemon and sage scent, which many users will appreciate. Being biobased and made in the USA adds an eco-friendly and quality assurance aspect.

The product comes in a liquid form that requires spraying, which might not suit users looking for wipes or ready-to-use pads. Also, while it is effective on many surfaces, users should test it on delicate materials first since enzyme cleaners can sometimes affect finishes. This cleaner is well-suited for people needing a strong, natural, and multi-surface enzymatic cleaner with odor control, especially for pet owners or households dealing with organic messes.