10 Best Cat Urine Removers 2025 in the United States

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a robust enzyme-based cleaner designed to tackle tough pet stains and odors, including cat urine. Its formula uses natural enzymes that break down urine and organic messes, making stains and smells disappear rather than just masking them. The scent is a clean 'original' fragrance, which is generally mild and not overpowering. This cleaner is safe to use on many surfaces, including carpets, floors, furniture, clothing, litter boxes, and pet carriers, making it very versatile for homes with pets.

The product is certified safe by the Carpet and Rug Institute, so it won’t damage colors or leave harmful residues, which is reassuring for households with kids or sensitive pets. It comes in a large 1-gallon bottle applied as a spray or drop, allowing easy treatment of affected areas. The formula is chlorine-free and eco-friendly, avoiding harsh chemicals and propellants, which makes it a safer choice for environmentally conscious users. Some users have mentioned the weight and size of the gallon bottle can be a bit bulky to handle.

This enzyme cleaner is a strong option for pet owners looking for a safe, effective, and multi-surface product to eliminate cat urine stains and odors without harmful chemicals. It has received many positive reviews endorsing its effectiveness.

Nature's Miracle Urine Destroyer Plus is designed to tackle severe cat urine stains using a powerful enzymatic formula that breaks down urine on contact and continues working as long as any residue remains. This makes it excellent for deep cleaning and odor removal. The large 1-gallon bottle is convenient for refilling smaller spray bottles, which is handy if you have multiple problem spots. It has a neutral odor labeled as 'Odor Remover,' so it doesn’t leave a strong fragrance behind, which is appreciated if you prefer scent-free cleaning.

The formula is safe to use around pets and home surfaces when used as directed. Application is straightforward—just pour or spray—but it is advisable to allow sufficient time for the product to work and dry before pets return to the area. This product works well for heavy stains and odor with a trusted enzymatic formula and large size, making it practical for homes with multiple cats.

Users should be mindful about testing on delicate surfaces before full application.

Nature’s Miracle® Advanced Stain & Odor Eliminator is designed specifically for tough pet messes like cat urine, feces, and vomit. Its enzyme-based formula actively breaks down these messes and continues working as long as the mess remains, which makes it effective for deep cleaning and odor removal. The product also uses patented microbes that help target stubborn pet odors, adding to its cleaning strength. It features a light fresh scent that helps mask any residual smells without being overpowering.

This cleaner is safe to use on a variety of surfaces including carpets, hard floors, furniture, and fabrics, making it versatile for different spots where pets might have accidents. The liquid form is easy to apply, providing convenience for pet owners.

It is a reliable choice for pet owners dealing with severe pet stains and odors who want a product trusted for decades. Those seeking a fully natural or quick-drying option may want to explore additional products.