10 Best Pet Urine Removers 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is an enzyme-based cleaner designed to tackle tough pet-related stains and odors. One of its standout features is its enzyme-activated formula, which effectively breaks down organic matter like urine and vomit, ensuring that both the stain and the accompanying smell are completely eliminated. This makes it a great option for households with pets, as it can be used on a variety of surfaces, including carpets, floors, furniture, and more. It's certified safe for pets and children, meaning you can use it without worrying about harmful chemicals lingering in your home.

There are a few things to keep in mind. While the product has a good reputation for odor neutralization and stain removal, it may require multiple applications for particularly stubborn stains, which can be a bit time-consuming. Additionally, although it's designed for all surfaces, it's wise to pre-test on hidden areas to avoid any potential discoloration.

In terms of ease of use, the spray bottle design makes application straightforward, but users should follow the instructions carefully to achieve the best results. The drying time is generally quick, which is beneficial for busy pet owners. This product is particularly well-suited for pet owners dealing with accidents from dogs and cats, as well as those who want a safe, effective solution for cleaning up after their furry friends. Its performance and safety features make it a solid addition to your cleaning supplies, especially if you have multiple pets or older animals that might have occasional accidents.

ANGRY ORANGE Pet Odor Eliminator is designed to tackle tough odors from pet urine, feces, and vomit quickly, using the natural power of orange oil for a fresh citrus scent. While it doesn’t specifically mention an enzyme-based formula, its ability to neutralize odors at their source makes it effective for strong smells. It works best on hard and sealed surfaces like floors, which covers many common pet mess areas, but it may not be ideal for use on carpets or fabrics where enzyme cleaners usually shine.

The product is formulated without harsh chemicals, parabens, or sulfates, making it safer for homes with pets and children when used as directed. Users will appreciate its pleasant scent that avoids the chemical smell typical of some cleaners. The spray comes in a convenient 24 oz bottle and dries fairly quickly, allowing for easy cleanup without long waiting times.

If your main concern is deep stain removal, especially on carpets, you might need a product specifically labeled as enzyme-based, since this one focuses more on odor elimination rather than intensive stain breakdown. ANGRY ORANGE is a strong choice for pet owners looking to freshen up hard surfaces and remove stubborn odors while avoiding harsh chemicals.

Nature's Miracle Urine Destroyer Plus for Dogs is specifically designed to tackle tough dog urine stains. One of its standout features is the enzymatic formula, which begins working immediately on contact and continues to break down stains as long as any bio-based mess remains. This makes it highly effective for severe stains, offering a powerful solution with minimal effort—just soak the area, let it sit for 15 minutes, and then blot it up with a cloth.

The formula also neutralizes odors, helping to eliminate unpleasant smells along with visible stains. Safety is a key consideration, and this product is safe to use around pets and children when used as directed. This makes it a great option for households with young ones and furry friends. Additionally, the product comes in a convenient 32 fl oz spray bottle made with 25% post-consumer recycled material, contributing to environmental sustainability.

However, some users might find the drying time longer than expected, and it may require multiple applications for particularly stubborn stains. The product dimensions and weight are manageable, making it easy to handle and store. Customer reviews are generally positive, with a 4.5-star rating from nearly 3,000 users. Given these features, Nature's Miracle Urine Destroyer Plus is a strong choice for pet owners dealing with severe urine stains and odors, offering an effective and safe cleaning solution.