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10 Best Enzyme Cleaner For Dog Urine 2025 in the United States

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#1

Winner

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Rating
10.0
Chosen by1,383
Surface Compatibility
Application Method
Scent

Most important from
16378 reviews

Surface Compatibility
Effectively lifts even deep, dark urine stains from carpets, leaving no lingering odor behind.
Application Method
The enzyme action requires patience—letting it sit for 10–15 minutes before blotting greatly improves stain removal.
Scent
Has a mild, pleasant scent that doesn’t overpower the room once dry.
Drying Time
Keep pets and children away from treated areas until fully dry, which can take up to two hours depending on surface and amount used.
Eco-Friendliness
Ideal for pet owners needing a reliable, non-toxic, and eco-friendly solution for persistent urine odors and stains.

The Rocco & Roxie Stain & Strong Odor Eliminator is a popular enzyme cleaner designed especially for pet stains and odors, including dog urine. It uses natural enzymes to break down organic messes, making it effective at removing tough urine stains and smells from carpets, floors, furniture, clothing, and other pet areas. One of its strengths is safety—it’s free of chlorine and harsh chemicals, certified safe for all carpet types, and non-toxic around pets and kids. This makes it a solid choice if you’re concerned about using harsh cleaners in your home.

It comes in a large 1-gallon size, which is practical for multiple uses, but it is a bit heavy and bulky to handle easily. The scent is the original, which is mild and not overpowering, so it won’t leave a strong perfume odor behind. Application is simple with a spray bottle, but drying time can vary depending on how much you use and the surface, so patience may be needed. The product is eco-friendly as it avoids harmful chemicals and propellants, fitting well for environmentally conscious users. Some users might find it takes a little time for the enzymes to fully eliminate odors, so immediate results aren’t always guaranteed. Also, while it is safe for many surfaces, testing on a small hidden area first is advised to avoid any color changes.

For pet owners of any size or type who need a reliable, gentle cleaner for urine and other organic stains, Rocco & Roxie provides a trusted option with strong cleaning power and a reputation for quality.

Rating
10.0
Chosen by1,383
Surface Compatibility
Application Method
Scent

Most important from
16378 reviews

Surface Compatibility
Effectively lifts even deep, dark urine stains from carpets, leaving no lingering odor behind.
Application Method
The enzyme action requires patience—letting it sit for 10–15 minutes before blotting greatly improves stain removal.
Scent
Has a mild, pleasant scent that doesn’t overpower the room once dry.
Drying Time
Keep pets and children away from treated areas until fully dry, which can take up to two hours depending on surface and amount used.
Eco-Friendliness
Ideal for pet owners needing a reliable, non-toxic, and eco-friendly solution for persistent urine odors and stains.
#2

ANGRY ORANGE Pet Odor Eliminator for Cat Urine, Carpet Stains, and Strong Smells – Fresh Scent Odor Remover- 24 oz

Rating
7.9
Enzyme Type
Scent
Application Method

Most important from
127718 reviews

Enzyme Type
Effectively eliminates even the toughest cat urine odors without any return of smell, outperforming all previous cleaners and professional treatments.
Scent
Leaves a fresh, pleasant orange scent that is noticeable but not overpowering, making the home smell clean and inviting.
Application Method
A little product goes a long way; it cleans thoroughly without needing to soak the area, which saves time and effort.

ANGRY ORANGE Pet Odor Eliminator is a spray-based enzyme cleaner designed to tackle tough pet odors, including dog and cat urine, feces, and vomit. It performs well on hard, sealed surfaces like floors, making it a suitable choice for cleaning messes in areas where pets frequently roam. The product is appreciated for its fresh scent, which users find pleasant and less harsh compared to many other odor removers, making it ideal for households with multiple pets.

Safety is an important feature of this product, as it contains no parabens, sulfates, or phthalates, ensuring it is gentle enough for use in homes with pets when used as directed. Packaged in a convenient 24-ounce spray bottle, ANGRY ORANGE provides a reliable and user-friendly solution for pet owners seeking a fast and effective odor eliminator that leaves a fresh scent without a chemical smell.

Rating
7.9
Enzyme Type
Scent
Application Method

Most important from
127718 reviews

Enzyme Type
Effectively eliminates even the toughest cat urine odors without any return of smell, outperforming all previous cleaners and professional treatments.
Scent
Leaves a fresh, pleasant orange scent that is noticeable but not overpowering, making the home smell clean and inviting.
Application Method
A little product goes a long way; it cleans thoroughly without needing to soak the area, which saves time and effort.
#3

Angry Orange Pet Odor Eliminator Concentrate for Cat Urine and Smells - Fresh Scent - 8 oz (Makes 128 oz of Cleaner)

Rating
7.3
Enzyme Type
Surface Compatibility
Scent

Most important from
76640 reviews

Enzyme Type
A concentrated formula that stretches a small bottle into a large supply, making it economical and long-lasting.
Surface Compatibility
Works well across multiple surfaces including carpets, upholstery, crates, and even tile or car interiors, showcasing great versatility.
Scent
The strong citrus scent initially can be overpowering but quickly fades to a pleasant, fresh aroma that brightens the room.
Application Method
Proper dilution is crucial; using too much concentrate can overwhelm with scent and even cause mild staining on carpets.

Angry Orange Pet Odor Eliminator Concentrate is designed to tackle tough pet odors, including urine smells, by targeting and eliminating them at the source rather than just masking them. It’s quite versatile, suitable for use on various surfaces like carpets, tile, upholstery, and even car interiors, which is great if you need a multi-surface cleaner. The product comes as a concentrate, so you dilute it before use, making it economical since a small 8-ounce bottle can make up to 128 ounces of usable cleaner.

Application involves spraying and scrubbing, a simple process for most users. It leaves behind a fresh linen scent, which many will find pleasant and not overwhelming. The formula is proudly made in the USA, which may reassure buyers about quality. If you’re looking for an enzyme cleaner that is effective, versatile, and easy to use with a nice scent, Angry Orange is a solid option, especially for dealing with strong pet odors on a variety of surfaces.

Rating
7.3
Enzyme Type
Surface Compatibility
Scent

Most important from
76640 reviews

Enzyme Type
A concentrated formula that stretches a small bottle into a large supply, making it economical and long-lasting.
Surface Compatibility
Works well across multiple surfaces including carpets, upholstery, crates, and even tile or car interiors, showcasing great versatility.
Scent
The strong citrus scent initially can be overpowering but quickly fades to a pleasant, fresh aroma that brightens the room.
Application Method
Proper dilution is crucial; using too much concentrate can overwhelm with scent and even cause mild staining on carpets.

Buying Guide for the Best Enzyme Cleaner For Dog Urine

Choosing the right enzyme cleaner for dog urine can make a significant difference in maintaining a clean and odor-free home. Enzyme cleaners are specifically designed to break down the proteins in urine, eliminating both the stain and the smell. When selecting an enzyme cleaner, it's important to consider several key specifications to ensure you get the best product for your needs. Understanding these specifications will help you make an informed decision and keep your home fresh and clean.
Enzyme TypeEnzyme type refers to the specific enzymes used in the cleaner to break down urine. Common enzymes include protease, amylase, and lipase. Protease is effective at breaking down proteins, which are a major component of urine. Amylase targets starches, and lipase breaks down fats. For dog urine, a cleaner with protease is particularly important because it effectively breaks down the proteins in the urine, eliminating both the stain and odor. If you have multiple types of stains, a cleaner with a combination of enzymes might be more effective.
Surface CompatibilitySurface compatibility indicates the types of surfaces the enzyme cleaner can be safely used on, such as carpets, hardwood floors, upholstery, and tiles. This is important because using the wrong cleaner on a surface can cause damage. Check the product label to ensure it is safe for the surfaces you intend to clean. If you have a variety of surfaces in your home, look for a versatile cleaner that is compatible with multiple surfaces.
ScentThe scent of an enzyme cleaner can vary from unscented to various fragrances like citrus or lavender. This is important because a strong or unpleasant scent can be overwhelming, especially in enclosed spaces. If you or your pets are sensitive to strong smells, you might prefer an unscented or lightly scented cleaner. On the other hand, if you enjoy a fresh-smelling home, a cleaner with a pleasant fragrance can be a good choice.
Application MethodThe application method refers to how the cleaner is applied, such as spray, pour, or foam. This is important because different methods can be more convenient for different types of stains and surfaces. For example, a spray bottle is easy to use for spot cleaning, while a pour bottle might be better for larger areas. Consider how you will be using the cleaner and choose an application method that suits your needs.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This is important because a longer drying time can be inconvenient, especially in high-traffic areas. If you need a quick solution, look for a cleaner with a shorter drying time. However, some cleaners with longer drying times might be more effective at deeply penetrating and breaking down stains.
Eco-FriendlinessEco-friendliness refers to the environmental impact of the cleaner, including whether it is biodegradable and free from harsh chemicals. This is important for those who are environmentally conscious or have pets and children who might be sensitive to chemicals. Look for products labeled as eco-friendly or biodegradable if this is a priority for you.

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