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10 Best Enzyme Pet Cleaner 2025 in the United States

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Our Top Picks

#1

Winner

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 1 Gal

Rating
10.0
Chosen by1,248
Enzyme Type
Surface Compatibility
Scent

Most important from
5006 reviews

Enzyme Type
This enzymatic formula dissolves cat urine completely, eliminating odors rather than just masking them, even on clothes and shoes.
Surface Compatibility
Safe to use on carpets, upholstery, hard floors, and washable fabrics, with detailed instructions to tackle even persistent urine stains.
Scent
The mild odor of the cleaner dissipates completely over time, leaving no lingering chemical smell.
Application Method
It’s crucial not to dilute the product to maintain its full effectiveness; using more product is better than watering it down.

Nature's Miracle Urine Destroyer Plus for Cats is designed specifically to tackle tough cat urine stains and odors. Its enzymatic formula starts breaking down urine on contact and keeps working as long as any residue remains, which helps remove stains deeply rather than just masking them. The product comes in a large 1-gallon bottle, making it convenient for refilling smaller spray bottles, which is handy if you have frequent messes. It carries an odor remover scent, which is mild and aimed at neutralizing unpleasant smells rather than adding a strong fragrance.

The cleaner is safe to use around pets and in the home when following the instructions, so there is no major concern about toxicity or harsh chemicals. Nature's Miracle is generally safe on carpets, upholstery, and hard floors, with a straightforward application process where you apply it directly to the stain. When dealing with severe or repeated cat urine issues, this product is a reliable choice thanks to its strong enzymatic action and pet-safe formulation.

While the large bottle size might be bulky for some, it offers a refill-friendly option that suits cat owners needing a thorough urine cleaner.

Rating
10.0
Chosen by1,248
Enzyme Type
Surface Compatibility
Scent

Most important from
5006 reviews

Enzyme Type
This enzymatic formula dissolves cat urine completely, eliminating odors rather than just masking them, even on clothes and shoes.
Surface Compatibility
Safe to use on carpets, upholstery, hard floors, and washable fabrics, with detailed instructions to tackle even persistent urine stains.
Scent
The mild odor of the cleaner dissipates completely over time, leaving no lingering chemical smell.
Application Method
It’s crucial not to dilute the product to maintain its full effectiveness; using more product is better than watering it down.
#2

Nature’s Miracle Advanced Stain And Odor Eliminator for Dogs, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes, 1 Gallon

Rating
9.7
Surface Compatibility
Scent
Application Method

Most important from
3339 reviews

Surface Compatibility
Works on a variety of messes including puppy accidents, food stains, and even on furniture and walls.
Scent
Has a pleasant scent that outperforms competitors by not leaving behind a strong chemical odor.
Application Method
The spray formula allows for targeted application and easy cleaning, especially when combined with blotting or brushing techniques.
Safety
Removes tough stains and odors from washable pet items, leaving them fresh and clean without harsh smells.

Nature’s Miracle Advanced Stain And Odor Eliminator is designed specifically for tough pet messes, using an enzymatic formula that breaks down stains and odors effectively. It works well on a variety of surfaces including carpets, hard floors, furniture, and clothing, making it a versatile choice for households with pets. The product has a fresh scent, which helps keep your home smelling pleasant without being overpowering. Its fast-drying formula means you don’t have to wait long before the area is ready to use again, which is convenient for busy pet owners. The liquid form is easy to apply, allowing you to target the problem spots accurately.

Safety-wise, it’s suitable for adult pets and generally safe to use around them when instructions are followed, but it’s always good to keep pets away until the area is dry. While it’s great for severe messes, it may require a bit more effort or repeated application on very old or stubborn stains. Also, the scent might not be ideal for those sensitive to fragrances. This enzyme cleaner provides a strong solution for odor and stain removal across various surfaces, making it a reliable option for pet owners.

Rating
9.7
Surface Compatibility
Scent
Application Method

Most important from
3339 reviews

Surface Compatibility
Works on a variety of messes including puppy accidents, food stains, and even on furniture and walls.
Scent
Has a pleasant scent that outperforms competitors by not leaving behind a strong chemical odor.
Application Method
The spray formula allows for targeted application and easy cleaning, especially when combined with blotting or brushing techniques.
Safety
Removes tough stains and odors from washable pet items, leaving them fresh and clean without harsh smells.
#3

Sunny & Honey Enzyme Cleaner & Stain Remover - 1 gal (128 fl oz), Spring Mint Scent - Pet & Kid Safe Pet Enzyme Cleaner - Heavy Duty Carpet Cleaner Solution

Rating
9.1
Enzyme Type
Surface Compatibility
Scent

Most important from
11104 reviews

Enzyme Type
Effectively removes both new and old pet stains, especially urine, while completely eliminating odors even on challenging surfaces like mattresses and carpets.
Surface Compatibility
Effectively removes both new and old pet stains, especially urine, while completely eliminating odors even on challenging surfaces like mattresses and carpets.
Scent
The product’s fresh spring mint scent is pleasant but can be strong when applied over large areas, sometimes requiring additional cleaning to reduce residue smell.
Application Method
Application is straightforward—spray, let it sit, and wipe or blot without the need for scrubbing, saving time and effort during cleanup.
Drying Time
Thorough drying with good ventilation or fans is recommended to avoid dampness after use, especially on thicker fabrics.
Safety
Safe for use around children and pets, providing peace of mind without harsh chemicals or toxic ingredients.

The Sunny & Honey Enzyme Cleaner & Stain Remover is a strong choice for pet owners needing to tackle urine and other pet messes on various surfaces. It uses natural enzymes to break down stains and odors, which makes it effective without harsh chemicals. Its spring mint scent adds a fresh smell without being overpowering, which is a nice touch for maintaining a pleasant home environment. One big plus is its versatility—it works well on carpets, couches, rugs, and even some leather surfaces, making it useful for different cleaning needs around the house. The application is simple: spray, wait, and wipe, with no scrubbing needed, saving you time and effort.

Also important is that this formula is safe for both kids and pets, using non-toxic, biodegradable ingredients, so you don’t have to worry about harsh chemicals around your family. However, the product is a liquid that might take some time to fully dry depending on surface type and room ventilation, so it’s best to allow adequate drying to avoid dampness. Some users have mentioned that it may require multiple applications on very old or tough stains. Additionally, since it’s a large 1-gallon container, it’s best suited for people who expect frequent use or have multiple pets.

If you want a family- and pet-safe enzymatic cleaner that can cover many surfaces and leaves a fresh mint scent, Sunny & Honey is a solid pick, especially for regular maintenance and moderate stain situations.

Rating
9.1
Enzyme Type
Surface Compatibility
Scent

Most important from
11104 reviews

Enzyme Type
Effectively removes both new and old pet stains, especially urine, while completely eliminating odors even on challenging surfaces like mattresses and carpets.
Surface Compatibility
Effectively removes both new and old pet stains, especially urine, while completely eliminating odors even on challenging surfaces like mattresses and carpets.
Scent
The product’s fresh spring mint scent is pleasant but can be strong when applied over large areas, sometimes requiring additional cleaning to reduce residue smell.
Application Method
Application is straightforward—spray, let it sit, and wipe or blot without the need for scrubbing, saving time and effort during cleanup.
Drying Time
Thorough drying with good ventilation or fans is recommended to avoid dampness after use, especially on thicker fabrics.
Safety
Safe for use around children and pets, providing peace of mind without harsh chemicals or toxic ingredients.

Buying Guide for the Best Enzyme Pet Cleaner

Choosing the right enzyme pet cleaner can make a significant difference in maintaining a clean and odor-free home, especially if you have pets. Enzyme cleaners are designed to break down organic materials like urine, feces, vomit, and other pet-related messes, making them highly effective for cleaning and deodorizing. When selecting an enzyme pet cleaner, it's important to consider several key specifications to ensure you get the best product for your needs.
Enzyme TypeEnzyme type refers to the specific enzymes used in the cleaner. Different enzymes target different types of organic matter. For example, proteases break down proteins, amylases break down starches, and lipases break down fats. It's important because the effectiveness of the cleaner depends on the type of mess you're dealing with. If you primarily need to clean up urine, look for a cleaner with urease enzymes. For a variety of messes, a cleaner with a combination of enzymes is ideal. Choose based on the common types of stains and odors you encounter.
Surface CompatibilitySurface compatibility indicates which surfaces the cleaner can be safely used on, such as carpets, upholstery, hardwood floors, or tiles. This is important because using the wrong cleaner on a surface can cause damage or discoloration. Cleaners are often labeled for specific surfaces, so check the product description to ensure it matches your needs. If you have multiple types of surfaces, look for a versatile cleaner that is safe for all of them. Choose based on the surfaces you need to clean most frequently.
ScentThe scent of the cleaner can affect the overall experience of using the product. Some enzyme cleaners have a strong fragrance to mask odors, while others are unscented or have a mild scent. This is important because a strong scent might be overwhelming or unpleasant for some people and pets. If you or your pets are sensitive to strong smells, opt for an unscented or lightly scented cleaner. Choose based on your preference for fragrance and sensitivity to smells.
Application MethodThe application method refers to how the cleaner is applied, such as spray, pour, or foam. This is important because it affects ease of use and effectiveness. Sprays are convenient for spot cleaning, while pour bottles might be better for larger areas. Foam can penetrate deeper into carpets and upholstery. Consider how you will be using the cleaner and choose the application method that suits your cleaning habits. Choose based on the size and type of messes you typically clean.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This is important because a longer drying time might be inconvenient, especially in high-traffic areas. Some cleaners dry quickly, while others may take several hours. If you need to use the cleaned area soon after application, look for a cleaner with a shorter drying time. Choose based on how quickly you need the area to be usable again.
SafetySafety refers to whether the cleaner is non-toxic and safe for pets and humans. This is important because some cleaners contain harsh chemicals that can be harmful if ingested or if they come into contact with skin. Look for products labeled as non-toxic, biodegradable, and safe for pets and children. Choose based on the safety needs of your household, especially if you have young children or pets who might come into contact with the cleaned areas.

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