10 Best Enzyme Pet Cleaner 2025 in the United States

Nature’s Miracle Advanced Stain And Odor Eliminator is designed specifically for tough pet messes, using an enzymatic formula that breaks down stains and odors effectively. It works well on a variety of surfaces including carpets, hard floors, furniture, and clothing, making it a versatile choice for households with pets. The product has a fresh scent, which helps keep your home smelling pleasant without being overpowering. Its fast-drying formula means you don’t have to wait long before the area is ready to use again, which is convenient for busy pet owners. The liquid form is easy to apply, allowing you to target the problem spots accurately.

Safety-wise, it’s suitable for adult pets and generally safe to use around them when instructions are followed, but it’s always good to keep pets away until the area is dry. While it’s great for severe messes, it may require a bit more effort or repeated application on very old or stubborn stains. Also, the scent might not be ideal for those sensitive to fragrances. This enzyme cleaner provides a strong solution for odor and stain removal across various surfaces, making it a reliable option for pet owners.

The Sunny & Honey Enzyme Cleaner & Stain Remover is a strong choice for pet owners needing to tackle urine and other pet messes on various surfaces. It uses natural enzymes to break down stains and odors, which makes it effective without harsh chemicals. Its spring mint scent adds a fresh smell without being overpowering, which is a nice touch for maintaining a pleasant home environment. One big plus is its versatility—it works well on carpets, couches, rugs, and even some leather surfaces, making it useful for different cleaning needs around the house. The application is simple: spray, wait, and wipe, with no scrubbing needed, saving you time and effort.

Also important is that this formula is safe for both kids and pets, using non-toxic, biodegradable ingredients, so you don’t have to worry about harsh chemicals around your family. However, the product is a liquid that might take some time to fully dry depending on surface type and room ventilation, so it’s best to allow adequate drying to avoid dampness. Some users have mentioned that it may require multiple applications on very old or tough stains. Additionally, since it’s a large 1-gallon container, it’s best suited for people who expect frequent use or have multiple pets.

If you want a family- and pet-safe enzymatic cleaner that can cover many surfaces and leaves a fresh mint scent, Sunny & Honey is a solid pick, especially for regular maintenance and moderate stain situations.

Rocco & Roxie’s Stain & Strong Odor Eliminator is an enzyme-based cleaner designed to tackle tough pet stains and odors, especially from dog and cat urine. It uses natural enzymes to break down organic messes, effectively removing both visible stains and lingering smells. This cleaner is safe for almost any surface in a pet’s environment — carpets, floors, furniture, clothing, and pet carriers — making it versatile for home use.

Certified safe by the Carpet and Rug Institute and free from harsh chemicals like chlorine, it can be used around pets and kids without worry. The scent, described as “original,” is subtle and does not overpower the home environment. Application is simple: spray it on after blotting up the mess and let it dry naturally. While the 1-gallon size may feel heavy or bulky to some, it ensures long-lasting use.

It is generally color-safe, but testing on hidden areas is advisable to prevent any potential color fading. Customer feedback is very positive, with many praising its effectiveness. For pet owners dealing with frequent accidents, this product provides a powerful and safe solution to maintain a fresh and clean home.