10 Best Enzyme Pet Cleaner 2025 in the United States

Nature's Miracle Urine Destroyer Plus for Cats is designed specifically to tackle tough cat urine stains and odors. Its enzymatic formula starts breaking down urine on contact and keeps working as long as any residue remains, which helps remove stains deeply rather than just masking them. The product comes in a large 1-gallon bottle, making it convenient for refilling smaller spray bottles, which is handy if you have frequent messes. It carries an odor remover scent, which is mild and aimed at neutralizing unpleasant smells rather than adding a strong fragrance.

The cleaner is safe to use around pets and in the home when following the instructions, so there is no major concern about toxicity or harsh chemicals. Nature's Miracle is generally safe on carpets, upholstery, and hard floors, with a straightforward application process where you apply it directly to the stain. When dealing with severe or repeated cat urine issues, this product is a reliable choice thanks to its strong enzymatic action and pet-safe formulation.

While the large bottle size might be bulky for some, it offers a refill-friendly option that suits cat owners needing a thorough urine cleaner.

Nature’s Miracle Advanced Stain And Odor Eliminator is designed specifically for tough pet messes, using an enzymatic formula that breaks down stains and odors effectively. It works well on a variety of surfaces including carpets, hard floors, furniture, and clothing, making it a versatile choice for households with pets. The product has a fresh scent, which helps keep your home smelling pleasant without being overpowering. Its fast-drying formula means you don’t have to wait long before the area is ready to use again, which is convenient for busy pet owners. The liquid form is easy to apply, allowing you to target the problem spots accurately.

Safety-wise, it’s suitable for adult pets and generally safe to use around them when instructions are followed, but it’s always good to keep pets away until the area is dry. While it’s great for severe messes, it may require a bit more effort or repeated application on very old or stubborn stains. Also, the scent might not be ideal for those sensitive to fragrances. This enzyme cleaner provides a strong solution for odor and stain removal across various surfaces, making it a reliable option for pet owners.

The Sunny & Honey Enzyme Cleaner & Stain Remover is a strong choice for pet owners needing to tackle urine and other pet messes on various surfaces. It uses natural enzymes to break down stains and odors, which makes it effective without harsh chemicals. Its spring mint scent adds a fresh smell without being overpowering, which is a nice touch for maintaining a pleasant home environment. One big plus is its versatility—it works well on carpets, couches, rugs, and even some leather surfaces, making it useful for different cleaning needs around the house. The application is simple: spray, wait, and wipe, with no scrubbing needed, saving you time and effort.

Also important is that this formula is safe for both kids and pets, using non-toxic, biodegradable ingredients, so you don’t have to worry about harsh chemicals around your family. However, the product is a liquid that might take some time to fully dry depending on surface type and room ventilation, so it’s best to allow adequate drying to avoid dampness. Some users have mentioned that it may require multiple applications on very old or tough stains. Additionally, since it’s a large 1-gallon container, it’s best suited for people who expect frequent use or have multiple pets.

If you want a family- and pet-safe enzymatic cleaner that can cover many surfaces and leaves a fresh mint scent, Sunny & Honey is a solid pick, especially for regular maintenance and moderate stain situations.