10 Best Enzyme Pet Cleaner 2026 in the United States

Rocco & Roxie’s Stain & Strong Odor Eliminator is an enzyme-based cleaner designed to tackle tough pet stains and odors, especially from dog and cat urine. It uses natural enzymes to break down organic messes, effectively removing both visible stains and lingering smells. This cleaner is safe for almost any surface in a pet’s environment — carpets, floors, furniture, clothing, and pet carriers — making it versatile for home use.

Certified safe by the Carpet and Rug Institute and free from harsh chemicals like chlorine, it can be used around pets and kids without worry. The scent, described as “original,” is subtle and does not overpower the home environment. Application is simple: spray it on after blotting up the mess and let it dry naturally. While the 1-gallon size may feel heavy or bulky to some, it ensures long-lasting use.

It is generally color-safe, but testing on hidden areas is advisable to prevent any potential color fading. Customer feedback is very positive, with many praising its effectiveness. For pet owners dealing with frequent accidents, this product provides a powerful and safe solution to maintain a fresh and clean home.

Nature’s Miracle Advanced Stain And Odor Eliminator is designed specifically for tough pet messes, using an enzymatic formula that breaks down stains and odors effectively. It works well on a variety of surfaces including carpets, hard floors, furniture, and clothing, making it a versatile choice for households with pets. The product has a fresh scent, which helps keep your home smelling pleasant without being overpowering. Its fast-drying formula means you don’t have to wait long before the area is ready to use again, which is convenient for busy pet owners. The liquid form is easy to apply, allowing you to target the problem spots accurately.

Safety-wise, it’s suitable for adult pets and generally safe to use around them when instructions are followed, but it’s always good to keep pets away until the area is dry. While it’s great for severe messes, it may require a bit more effort or repeated application on very old or stubborn stains. Also, the scent might not be ideal for those sensitive to fragrances. This enzyme cleaner provides a strong solution for odor and stain removal across various surfaces, making it a reliable option for pet owners.

Nature's Miracle Urine Destroyer Plus for Cats is designed specifically to tackle tough cat urine stains and odors. Its enzymatic formula starts breaking down urine on contact and keeps working as long as any residue remains, which helps remove stains deeply rather than just masking them. The product comes in a large 1-gallon bottle, making it convenient for refilling smaller spray bottles, which is handy if you have frequent messes. It carries an odor remover scent, which is mild and aimed at neutralizing unpleasant smells rather than adding a strong fragrance.

The cleaner is safe to use around pets and in the home when following the instructions, so there is no major concern about toxicity or harsh chemicals. Nature's Miracle is generally safe on carpets, upholstery, and hard floors, with a straightforward application process where you apply it directly to the stain. When dealing with severe or repeated cat urine issues, this product is a reliable choice thanks to its strong enzymatic action and pet-safe formulation.

While the large bottle size might be bulky for some, it offers a refill-friendly option that suits cat owners needing a thorough urine cleaner.