10 Best Liver Support For Dogs 2025 in the United States

The Natural Dog Company Stinky Liver & Kidney Supplement Chews is designed to offer comprehensive support for a dog's liver and kidney health. The product contains a blend of natural ingredients such as Milk Thistle, Apple Cider Vinegar, and Curcumin which are known for their detoxifying properties. This can help in promoting toxin elimination, balancing liver enzymes, enhancing bile production, and supporting kidney filtration.

The formula also aims to improve digestion, immunity, and vitality, making it suitable for active dogs, senior dogs, or those needing organ detoxification. Each container includes 90 chews and the supplement is intended to be given twice a year, simplifying the routine for pet owners. The ingredients are vet-approved and the product is made in the USA, which may provide additional confidence in its safety and quality.

However, the chews have a strong odor, which although appealing to dogs, might be off-putting to some owners. It's also important to note that this supplement is not recommended for puppies under 12 weeks, pregnant or nursing dogs, or pets with existing health conditions without prior vet approval. Potential digestive upset could occur if not introduced slowly, particularly for dogs with sensitive stomachs. Owners should monitor their pets and consult their veterinarian to ensure it's the right fit for their dog.

The SilymarinAdvanced Liver Health Supplement is designed specifically for large dogs needing liver support, combining milk thistle and S-Adenosylmethionine (SAMe), which are well-regarded natural ingredients for liver detox and repair. Each tablet offers 425 mg of SAMe and 35 mg of silybin, the active compound in milk thistle, helping to eliminate toxins and reduce liver inflammation. The supplement also aims to support cognitive function, which can be a bonus for older dogs.

The tablets are easy to administer—uncoated and can be given whole, split, or crushed with food—and the formula is free from artificial additives, gluten, and common fillers, appealing to owners looking for a natural option. It’s developed with veterinary experts, adding trustworthiness and ensuring the dosage suits large breed dogs. However, the product is only sold as a 30-tablet pack, so longer-term use means repurchasing.

Although it supports liver health, this supplement should be part of a broader care plan under a vet’s guidance, especially if your dog has serious liver issues. For pet owners wanting a natural, vet-designed liver support for large dogs, this product represents a solid choice best used with professional advice and monitoring.

Nutramax Laboratories Denamarin Liver Health Supplement for Large Dogs is designed to support liver function using two main ingredients: S-Adenosylmethionine (SAMe) and Silybin. SAMe helps boost antioxidant levels, particularly glutathione, which is important for detoxifying the liver. Silybin, derived from milk thistle, is included in a form that allows for better absorption compared to standard extracts.

The supplement comes in tablet form and is flavored with liver, making it palatable for dogs. The dosage recommendation is straightforward: one tablet per day for large breeds, administered on an empty stomach for optimal absorption. Nutramax Laboratories, the manufacturer, has a strong reputation in the pet health industry with over 30 years of experience, and their products are widely recommended by veterinarians.

The supplement is also backed by scientific research, ensuring its safety and efficacy. This product is best suited for dog owners looking for a high-quality, veterinarian-recommended liver health supplement for their large breed dogs.