10 Best Liver Support For Dogs 2025 in the United States

Nutramax Laboratories Denamarin Liver Health Supplement for Large Dogs is designed to support liver function using two main ingredients: S-Adenosylmethionine (SAMe) and Silybin. SAMe helps boost antioxidant levels, particularly glutathione, which is important for detoxifying the liver. Silybin, derived from milk thistle, is included in a form that allows for better absorption compared to standard extracts.

The supplement comes in tablet form and is flavored with liver, making it palatable for dogs. The dosage recommendation is straightforward: one tablet per day for large breeds, administered on an empty stomach for optimal absorption. Nutramax Laboratories, the manufacturer, has a strong reputation in the pet health industry with over 30 years of experience, and their products are widely recommended by veterinarians.

The supplement is also backed by scientific research, ensuring its safety and efficacy. This product is best suited for dog owners looking for a high-quality, veterinarian-recommended liver health supplement for their large breed dogs.

The Natural Dog Company Stinky Liver & Kidney Supplement Chews is designed to offer comprehensive support for a dog's liver and kidney health. The product contains a blend of natural ingredients such as Milk Thistle, Apple Cider Vinegar, and Curcumin which are known for their detoxifying properties. This can help in promoting toxin elimination, balancing liver enzymes, enhancing bile production, and supporting kidney filtration.

The formula also aims to improve digestion, immunity, and vitality, making it suitable for active dogs, senior dogs, or those needing organ detoxification. Each container includes 90 chews and the supplement is intended to be given twice a year, simplifying the routine for pet owners. The ingredients are vet-approved and the product is made in the USA, which may provide additional confidence in its safety and quality.

However, the chews have a strong odor, which although appealing to dogs, might be off-putting to some owners. It's also important to note that this supplement is not recommended for puppies under 12 weeks, pregnant or nursing dogs, or pets with existing health conditions without prior vet approval. Potential digestive upset could occur if not introduced slowly, particularly for dogs with sensitive stomachs. Owners should monitor their pets and consult their veterinarian to ensure it's the right fit for their dog.

The Zesty Paws Turmeric Curcumin for Dogs is a versatile supplement designed to support liver health, along with joint, digestive, and cardiovascular benefits. It contains natural and organic ingredients like Turmeric and Curcumin, which are known for their anti-inflammatory and antioxidant properties. Enhanced with BioPerine, these soft chews help improve nutrient absorption, making them more effective for your dog's health.

Coconut oil is also included to support skin health and cognitive function. The product is shellfish-free and suitable for all breeds and life stages, making it widely applicable. The 250-count pack offers a generous supply, and the duck flavor makes it appealing to dogs.

The brand Zesty Paws has a strong reputation, backed by positive customer reviews and a 100% satisfaction guarantee, which adds to its credibility. Owners specifically seeking liver-focused support should consider if the broad-spectrum approach meets their needs.