10 Best Spider Spray Indoor 2025 in the United States

Ortho Home Defense Insect Killer is a versatile spray designed to tackle a wide range of household pests, including spiders, ants, and roaches. One of its biggest strengths is the long-lasting protection it offers—up to 12 months on non-porous indoor surfaces—meaning you don’t have to reapply frequently. The 1.33-gallon size is generous and comes with a battery-powered Comfort Wand, making it relatively easy to use with continuous spray delivery, which helps cover large areas smoothly.

In terms of effectiveness, it not only targets spiders but also other common indoor pests like fleas and ticks, making it a good choice if you want a multi-purpose insect killer. The residual effect means it keeps working well after application, which is helpful for preventing future infestations. The product is meant for both indoor use (like kitchens and bathrooms) and outdoor perimeter treatment, adding flexibility.

Regarding safety, the product is designed for indoor use but, as with most insecticides, it’s important to follow label instructions carefully to avoid contact with skin or pets during and shortly after application. There is no mention of a strong or unpleasant odor in the product brief, which suggests it’s likely mild or tolerable for indoor environments. The spray’s liquid formula and included Comfort Wand simplify application, though the container is somewhat heavy (over 12 pounds), which might be a bit cumbersome for some people to handle, especially when full. This insect killer is a solid choice for anyone looking to control spiders along with other pests inside the home, especially if you want a product that provides long-term protection and covers a variety of insects. Just be mindful of safety precautions and the weight if you plan to apply it frequently or on multiple surfaces.

The Ortho Home Defense Insect Killer for Indoor & Perimeter2 is a versatile pest control solution designed for use both indoors and outdoors. It effectively targets a wide range of pests, including ants, roaches, spiders, fleas, and more, thanks to its active ingredients, Bifenthrin and Zeta-Cypermethrin. One of the standout features is its long-lasting residual effect, providing up to 12 months of protection against ants, roaches, and spiders on non-porous surfaces, making it a good choice for lasting peace of mind.

The Comfort Wand is a user-friendly addition, allowing for easy and precise application without causing hand fatigue, which is especially helpful for larger areas or frequent use. Safety-wise, it's designed for confidence in use around kitchens, bathrooms, and other sensitive areas, although it’s always wise to follow all safety instructions provided. The spray is generally praised for its lack of strong, lingering odors, which can be a significant plus for indoor use.

However, like many chemical sprays, it’s important to handle it carefully and keep it away from children and pets. While effective against a range of insects, its performance against less common pests like scorpions and earwigs may vary. Additionally, its effectiveness on porous surfaces might not be as long-lasting. This spray is a comprehensive and user-friendly solution for common household pests, offering long-term protection and ease of use with its Comfort Wand. It’s ideal for those looking for an all-around pest control option without frequent reapplications.

The Mighty Mint 16 oz Peppermint Oil Insect & Pest Spray is a natural option for those dealing with spiders and other pests like ants. One of its major strengths is its use of powerful US peppermint oil, which is a natural ingredient known to be effective in repelling pests. This makes it a good choice for those seeking a non-chemical solution. The spray is extra concentrated, which helps in providing long-lasting protection. This means you won't need to reapply it frequently, saving you time and effort.

Users will also appreciate that it's safe to use as directed, minimizing concerns about harmful chemicals in the home, especially around pets and children. Its mint scent can be a refreshing change compared to the chemical odors associated with traditional insect sprays. However, if you're sensitive to strong smells, this might be a drawback. The product's ease of application and cleanup adds to its user-friendly appeal.

On the downside, as it comes in an aerosol form, it may not be as precise in application as other formats, potentially leading to wastage. Additionally, while effective against spiders and ants, its performance against other pests might not be as strong as specialized products. Mighty Mint is a safe, natural, and easy-to-use indoor spider spray, but its strong mint scent and aerosol delivery could be potential drawbacks for some users.